Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Anivia

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Vayne vs Anivia is a decisive matchup in LoL patch 26.7. Anivia wins with a 80.0% win rate (+60.0%) over Vayne based on 5 games. Anivia holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Anivia matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Anivia - 20.0% win rateAnivia(20.0%)
Vayne - 20.0% win rate in this matchup
Vayne
20.0% WR
VS
Anivia vs Vayne matchup - 80.0% win rate
Anivia
80.0% WR

Who Wins the Vayne vs Anivia Matchup?

Anivia wins the Vayne vs Anivia matchup
Winner
Anivia
Matches: 5
20.0%
Win Rate
80.0%
6.8
CS / min
7.2
915
DMG / min
668
12,553
Gold / game
11,841
235
Heal / min
194
371
DMG Mitigated / min
609
0.4
CC / min
1.4
0.0%
Early Game WR
100.0%
33.3%
Late Game WR
66.7%

Vayne vs Anivia Matchup Summary

The Vayne vs Anivia matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Anivia wins with a 80.0% win rate compared to Vayne's 20.0%, giving Anivia a 60.0 percentage point advantage. Anivia dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Anivia leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Anivia has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Anivia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Anivia Laning Phase Breakdown

Anivia wins the laning phase against Vayne in League of Legends

Anivia is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Anivia holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.8Vayne
7.2Anivia
Anivia edges out Vayne by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Anivia.
Damage
915Vayne
668Anivia
Vayne heavily out-damages Anivia by 247 DMG/min, dominating both short trades and all-in fights. Anivia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
12,553Vayne
11,841Anivia
Vayne earns 712 more gold per game than Anivia, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.4Vayne
1.4Anivia
Anivia brings significantly more crowd control than Vayne, with 1.0 more seconds of CC per minute. This large utility gap makes Anivia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
606Vayne
803Anivia
Anivia vastly out-sustains Vayne, healing and mitigating 197 more damage per minute. This massive durability gap means Anivia can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Anivia

Berserker's Greaves is the optimal boots choice against Anivia, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Anivia are Essence Reaver, Stormrazor and Experimental Hexplate. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Anivia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Anivia matchup.

Early Game vs Late Game

Early Game
Anivia
100.0%
+100.0% advantage
Vayne early game win rateVayne0.0%
Anivia early game win rateAnivia100.0%
Late Game
Anivia
66.7%
+33.3% advantage
Vayne late game win rateVayne33.3%
Anivia late game win rateAnivia66.7%

Anivia dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Vayne. This lopsided early game means Anivia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Anivia is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Vayne. Extended games heavily favor Anivia, whose kit and scaling make them a dominant force in team fights and objective control.

Anivia holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Anivia

Precision rune tree - Vayne primary runes vs AniviaPrecision
Fleet Footwork - best Vayne rune vs AniviaAbsorb Life - best Vayne rune vs AniviaLegend: Alacrity - best Vayne rune vs AniviaCut Down - best Vayne rune vs Anivia
Sorcery rune tree - Vayne secondary runes vs AniviaSorcery
Celerity - best Vayne rune vs AniviaNimbus Cloak - best Vayne rune vs Anivia
100.0% WR

The Precision and Sorcery rune setup gives Vayne the best tools to compete against Anivia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Anivia - Frequently Asked Questions

How does Vayne do against Anivia in League of Legends?

Anivia wins the Vayne vs Anivia matchup with a 80.0% win rate compared to Vayne's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.7.

How does Vayne do against Anivia in the early game?

In the early game, Anivia has the advantage against Vayne with a 100.0% win rate versus 0.0%. Anivia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Anivia in the late game?

In the late game, Anivia takes over the Vayne vs Anivia matchup with a 66.7% win rate compared to 33.3%. Anivia scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Anivia matchup?

Anivia wins the matchup against Vayne with a 80.0% win rate in League of Legends patch 26.7. The 60.0 percentage point advantage means Anivia is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Vayne build against Anivia?

The best Vayne build against Anivia includes Essence Reaver, Stormrazor, Experimental Hexplate with Berserker's Greaves. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Anivia?

The best Vayne runes against Anivia use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Anivia matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Anivia?

No, Vayne struggles against Anivia with only a 20.0% win rate. Anivia has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Anivia's lead.

How do I play Vayne against Anivia?

When playing Vayne against Anivia, play cautiously and avoid Anivia's power spikes. Look for jungle assistance and team-dependent plays since Anivia has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.