- Win Rate
- 49.0%
- Pick Rate
- 2.0%
- Ban Rate
- 6.4%
Syndra Mid Runes: Keystone & Shards
- Patch
- 26.20
- Games
- 4,019
- Lane
- Mid
- Tier
- All Tiers
- Last Updated
- Oct 18, 2026 UTC
- Methodology
- Data Methodology
- Author
- Dakota Chinnick
Best Mid Syndra runes for LoL Patch 26.20 - First Strike from the Inspiration tree with Sorcery secondary (69.2% WR, 1.0% pick rate). Syndra's optimal primary runes are First Strike, Cash Back, Triple Tonic, Cosmic Insight. Secondary tree: Manaflow Band, Transcendence.
Primary Tree
Inspiration
First StrikeAttacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal
Cooldown:
Cash BackGet 7.5% Gold back when you purchase Legendary Items.
Triple TonicUpon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.
Cosmic Insight+
+
Manaflow BandHitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.
After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.
Cooldown: 15 seconds
TranscendenceGain bonuses upon reaching the following levels:
Level 5: +5
Level 8: +5
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.
Primary Tree
Sorcery
Arcane CometDamaging a champion with an ability hurls a comet at their location, dealing increased damage based on distance.
Cooldown: 20 - 8s
Damage amplification scales up to 100% at 750 range.
Manaflow BandHitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.
After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.
Cooldown: 15 seconds
TranscendenceGain bonuses upon reaching the following levels:
Level 5: +5
Level 8: +5
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.
ScorchYour next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.
Cooldown: 10s
Triple TonicUpon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.
Cosmic Insight+
+
Every Syndra Mid Keystone and Secondary Tree (Patch 26.20)
3,860 gamesSyndra Mid runs First Strike in 35% of games, with a 50.9% win rate. Sorcery is the usual secondary tree (63%). Standard stat shards: Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense).
Keystones
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| First StrikeMost played | 35.3% | 50.9% | 1,362 |
| Arcane Comet | 31.9% | 48.5% | 1,231 |
 Electrocute | 28.8% | 47.7% | 1,110 |
 Summon Aery | 1.7% | 56.3% | 64 |
Secondary trees
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| SorceryMost played | 62.7% | 49.2% | 2,421 |
| Inspiration | 24.9% | 47.8% | 963 |
 Precision | 8.6% | 51.1% | 333 |
 Domination | 2.1% | 51.9% | 81 |
 Resolve | 1.6% | 46.8% | 62 |
Pick rate is the share of Syndra games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.
Syndra Minor Runes by Tree
Every minor rune Syndra players take, grouped by rune tree, with how often it is picked and how often it wins.
Sorcery
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| TranscendenceMost played | 91.9% | 48.9% | 3,549 |
| Manaflow Band | 90.2% | 49.1% | 3,480 |
| Scorch | 34.9% | 48.7% | 1,346 |
 Gathering Storm | 5.8% | 50.9% | 224 |
 Axiom Arcanist | 3.9% | 48.7% | 150 |
 Absolute Focus | 1.5% | 47.4% | 57 |
Inspiration
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Cosmic InsightMost played | 54.8% | 49.2% | 2,117 |
| Triple Tonic | 30.4% | 50.2% | 1,174 |
 Magical Footwear | 29.9% | 48.7% | 1,156 |
 Biscuit Delivery | 28.4% | 48.7% | 1,095 |
| Cash Back | 8.2% | 58.4% | 317 |
 Jack Of All Trades | 3.4% | 56.1% | 132 |
Domination
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Ultimate HunterMost played | 30.1% | 47.8% | 1,160 |
 Grisly Mementos | 28.1% | 47.3% | 1,086 |
 Taste of Blood | 25.3% | 48.2% | 977 |
 Cheap Shot | 6.1% | 44.7% | 235 |
Precision
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Legend: HasteMost played | 7.4% | 50.4% | 284 |
 Cut Down | 6.9% | 53.4% | 268 |
 Presence of Mind | 1.3% | 45.1% | 51 |
 Coup de Grace | 1.3% | 44.0% | 50 |
Resolve
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Bone PlatingMost played | 1.5% | 45.6% | 57 |
Syndra Stat Shards
Which stat shards Syndra players choose in each of the three shard rows, and the win rate of each.
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Adaptive Force (flex)Most played | 95.0% | 48.7% | 3,666 |
 Attack Speed (offense) | 86.2% | 49.0% | 3,328 |
 Health Scaling (defense) | 66.7% | 49.0% | 2,573 |
| Health (defense) | 29.8% | 48.8% | 1,149 |
| Adaptive Force (offense) | 9.1% | 45.0% | 351 |
 Move Speed (flex) | 4.7% | 56.3% | 183 |
 Ability Haste (offense) | 4.7% | 57.5% | 181 |
 Tenacity and Slow Resist (defense) | 3.6% | 51.4% | 138 |
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Syndra Runes FAQ - Patch 26.20
What is the best keystone for Syndra Mid?
First Strike: Syndra Mid takes it in 35% of ranked games and wins 50.9% of 1,362 games. Alternatives: Arcane Comet (32%, 48.5%), Electrocute (29%, 47.7%).
What stat shards should Syndra take?
Most Syndra players take Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.
What are the best Syndra runes in patch 26.20?
The best Syndra runes in patch 26.20 use the Inspiration tree with First Strike, Cash Back, Triple Tonic, and Cosmic Insight, and the Sorcery tree with Manaflow Band and Transcendence. This rune setup achieves a 69.2% win rate with a 1.0% pick rate.
What is the win rate for Syndra's best rune page?
Syndra's best rune page has a 69.2% win rate in patch 26.20, which is +20.2% compared to Syndra's average win rate. This rune setup has a 1.0% pick rate among Syndra players.
What keystone should I use on Syndra?
First Strike from the Inspiration tree is the best keystone rune for Syndra in patch 26.20. This keystone synergizes well with Syndra's kit and provides a 69.2% win rate.
What is Syndra's primary rune tree?
Syndra's primary rune tree is Inspiration. The optimal Inspiration runes for Syndra are First Strike, Cash Back, Triple Tonic, and Cosmic Insight, with First Strike being the keystone of choice.
What is Syndra's secondary rune tree?
Syndra's best secondary rune tree is Sorcery. The recommended Sorcery runes are Manaflow Band and Transcendence, which complement Syndra's Inspiration primary tree.
What are alternative rune setups for Syndra?
An alternative Syndra rune setup uses Arcane Comet from the Sorcery tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Syndra's runes?
Syndra's top rune page has a 1.0% pick rate in patch 26.20. This indicates that 1.0% of Syndra players use the First Strike setup with Inspiration and Sorcery trees.