Cleanse Skill

Is Cleanse good in Slay the Spire 2?

In Slay the Spire 2, Cleanse is an uncommon skill from the Necrobinder card pool. Its effect: Summon 3. Exhaust 1 card from your Draw Pile. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 271 tracked runs its win rate sits at 25.3%, 11.4% ahead of the 13.8% all-deck baseline. It sees niche play, included in only 1.3% of eligible runs. Taken 15.4% of the times it is offered, it lands close to neutral on the pick-versus-skip split: 25.0% for runs that took it against 26.6% for runs that passed, a -1.6% pick lift over 216 decided runs. Within Necrobinder runs it’s drafted 7.3% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +28.5% when the two share a deck. On the relic side, Nunchaku is its standout companion, worth a +28.8% win-rate swing alongside it. It costs 1 energy, gets upgraded 27.4% of the time, and tends to be picked up near floor 14.

Upgrading the card adds +2 Summon to its stat line. Of the runs that drafted it, 68 ended in victory against 201 deaths and 2 abandons. Its most common run-ender is Decimillipede Elite, finishing 5.9% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Cleanse fits a Necrobinder deck.

Pick or Skip: Cleanse

Players take Cleanse in 15.4% of the 1482 offers it appears in; those runs win 25.0% against 26.6% for runs that passed, a pick lift of -1.6% over 216 decided runs.

Taken 229 times out of 1482 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Cleanse

Of the 4 pickup windows recorded for Cleanse, Act 3 is the best: 56.0% across 25 runs.

Win rate of runs by the act Cleanse entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Cleanse

Cleanse’s strongest card pairings so far are Mad Science (+28.5%), Neurosurge (+23.8%), and Enfeebling Touch (+19.8%), each shown with the win-rate lift it adds.

Mad Science+28.5%17 runsNeurosurge+23.8%40 runsEnfeebling Touch+19.8%71 runsLegion of Bone+17.9%19 runsMelancholy+17.9%26 runsTransfigure+17.8%34 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cleanse Win Rate by Class

Exclusive to the Necrobinder, Cleanse posts a 25.5% win rate over 265 tracked runs.

The Necrobinderappears in 7.3% of its runs (265 tracked)

Best Relics for Cleanse

The relics that swing Cleanse’s win rate the most are Nunchaku (+28.8%), Eternal Feather (+27.8%), and Centennial Puzzle (+24.8%), with each lift shown.

Nunchaku+28.8%15 runsEternal Feather+27.8%23 runsCentennial Puzzle+24.8%46 runsLetter Opener+23.2%22 runsFunerary Mask+23.1%20 runsAnchor+22.7%39 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cleanse Card Details

A 1-energy uncommon skill, Cleanse is upgraded 27.4% of the time and tends to enter the deck around floor 14.

Summon 3. Exhaust 1 card from your Draw Pile.

Upgrade: +2 Summon

What Ends Runs with Cleanse

Runs holding Cleanse end most often against Decimillipede Elite (5.9%), Test Subject Boss (4.8%), and Knowledge Demon Boss (4.8%) — the share of its runs each accounts for is shown.

• Decimillipede Elite5.9% of runs
• Test Subject Boss4.8% of runs
• Knowledge Demon Boss4.8% of runs
• Infested Prisms Elite4.4% of runs
• Queen Boss4.1% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.