Gamma Blast•Attack

Is Gamma Blast good in Slay the Spire 2?

Gamma Blast is an uncommon Regent attack in Slay the Spire 2. In combat it resolves as: Deal 13 damage. Apply 2 Weak. Apply 2 Vulnerable. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 29 recorded runs, decks running it win 24.1% of the time, comfortably clear of the 12.6% average, by 11.5%. It’s a more selective pick, turning up in just 5.6% of decks that could run it. Regent players keep it in 17.5% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Glow — together they post a +75.9% swing in win rate. It also has strong chemistry with the relic Bag of Marbles, which moves its win rate by +75.9%. At 0 energy, it’s upgraded in 12.5% of runs and usually joins the deck around floor 12.

Upgraded, it gains +5 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 7 wins, 22 deaths, and 0 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Terror Eel Elite, which closes out 10.3% of its appearances. Read on for Gamma Blast’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Gamma Blast

Ranked by win-rate lift, Gamma Blast performs best alongside Glow (+75.9%), Mad Science (+75.9%), and Bombardment (+75.9%).

Glow+75.9%3 runsMad Science+75.9%3 runsBombardment+75.9%3 runsBig Bang+55.9%5 runsCalamity+42.5%3 runsDevastate+42.5%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Gamma Blast Win Rate by Class

Gamma Blast is drafted only by the Regent, where it holds a 24.1% win rate across 29 runs.

The Regentappears in 17.5% of its runs (29 tracked)

Best Relics for Gamma Blast

Gamma Blast pairs best with the relics Bag of Marbles (+75.9%), Strawberry (+75.9%), and Horn Cleat (+50.9%), ranked by win-rate lift.

Bag of Marbles+75.9%4 runsStrawberry+75.9%3 runsHorn Cleat+50.9%4 runsGorget+42.5%3 runsFencing Manual+42.5%6 runsKusarigama+42.5%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Gamma Blast Card Details

Gamma Blast is an uncommon attack costing 0 energy; it’s upgraded in 12.5% of runs and usually picked up by floor 12.

Deal 13 damage. Apply 2 Weak. Apply 2 Vulnerable.

Upgrade: +5 Damage

What Ends Runs with Gamma Blast

Gamma Blast’s most common run-enders are Terror Eel Elite (10.3%), Infested Prisms Elite (6.9%), and Ceremonial Beast Boss (6.9%).

• Terror Eel Elite10.3% of runs
• Infested Prisms Elite6.9% of runs
• Ceremonial Beast Boss6.9% of runs
• Louse Progenitor Normal6.9% of runs
• Decimillipede Elite6.9% of runs

See Also

Compare Gamma Blast with the rest of the best Slay the Spire 2 cards, relics, and classes below.