Gamma Blast•Attack

Is Gamma Blast good in Slay the Spire 2?

Gamma Blast is an uncommon Regent attack in Slay the Spire 2. In combat it resolves as: Deal 13 damage. Apply 2 Weak. Apply 2 Vulnerable. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 97 recorded runs, decks running it win 23.3% of the time, comfortably clear of the 18.9% average, by 4.4%. It’s a more selective pick, turning up in just 2.6% of decks that could run it. Regent players keep it in 14.1% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Spoils of Battle — together they post a +23.6% swing in win rate. It also has strong chemistry with the relic Ripple Basin, which moves its win rate by +28.8%. At 0 energy, it’s upgraded in 17.0% of runs and usually joins the deck around floor 12.

Upgraded, it gains +5 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 21 wins, 69 deaths, and 7 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 7.2% of its appearances. Read on for Gamma Blast’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Gamma Blast

Ranked by win-rate lift, Gamma Blast performs best alongside Spoils of Battle (+23.6%), Big Bang (+20.3%), and Mad Science (+19.8%).

Spoils of Battle+23.6%12 runsBig Bang+20.3%17 runsMad Science+19.8%7 runsBombardment+17.4%8 runsSpectrum Shift+15.3%9 runsPale Blue Dot+14.8%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Gamma Blast Win Rate by Class

Gamma Blast is played across 2 classes, led by Regent (23.3%) and Ironclad (0.0%) by win rate.

The Regent23.3%96 runsThe Ironclad0.0%1 runs

Best Relics for Gamma Blast

Gamma Blast pairs best with the relics Ripple Basin (+28.8%), Fencing Manual (+23.6%), and Vajra (+23.3%), ranked by win-rate lift.

Ripple Basin+28.8%6 runsFencing Manual+23.6%12 runsVajra+23.3%10 runsBag of Marbles+21.1%11 runsStrawberry+19.8%8 runsMercury Hourglass+19.8%8 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Gamma Blast Card Details

Gamma Blast is an uncommon attack costing 0 energy; it’s upgraded in 17.0% of runs and usually picked up by floor 12.

Deal 13 damage. Apply 2 Weak. Apply 2 Vulnerable.

Upgrade: +5 Damage

What Ends Runs with Gamma Blast

Gamma Blast’s most common run-enders are Knowledge Demon Boss (7.2%), Test Subject Boss (5.2%), and Terror Eel Elite (4.1%).

• Knowledge Demon Boss7.2% of runs
• Test Subject Boss5.2% of runs
• Terror Eel Elite4.1% of runs
• Decimillipede Elite4.1% of runs
• Infested Prisms Elite4.1% of runs

See Also

Compare Gamma Blast with the rest of the best Slay the Spire 2 cards, relics, and classes below.