Genetic Algorithm•Skill

Is Genetic Algorithm good in Slay the Spire 2?

In Slay the Spire 2, Genetic Algorithm is a rare skill from the Defect card pool. Its effect: Gain Block. Permanently increase this card's Block by. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 54 tracked runs its win rate sits at 26.0%, 7.0% ahead of the 18.9% all-deck baseline. It sees niche play, included in only 1.4% of eligible runs. Within Defect runs it’s drafted 9.1% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Creative AI, which lifts its win rate by +21.1% when the two share a deck. On the relic side, Anchor??? is its standout companion, worth a +21.1% win-rate swing alongside it. It costs 1 energy, gets upgraded 15.0% of the time, and tends to be picked up near floor 15.

Of the runs that drafted it, 13 ended in victory against 37 deaths and 4 abandons. Its most common run-ender is Queen Boss, finishing 11.1% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Genetic Algorithm fits a Defect deck.

Best Cards to Pair with Genetic Algorithm

Genetic Algorithm’s strongest card pairings so far are Creative AI (+21.1%), Signal Boost (+18.7%), and Thunder (+17.6%), each shown with the win-rate lift it adds.

Creative AI+21.1%4 runsSignal Boost+18.7%7 runsThunder+17.6%13 runsCompact+16.2%8 runsFTL+16.2%9 runsMachine Learning+14.0%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genetic Algorithm Win Rate by Class

Of the 2 classes that draft Genetic Algorithm, it performs best with Defect (26.5%) and Necrobinder (0.0%).

The Defect26.5%53 runsThe Necrobinder0.0%1 runs

Best Relics for Genetic Algorithm

The relics that swing Genetic Algorithm’s win rate the most are Anchor??? (+21.1%), Oddly Smooth Stone (+19.3%), and Joss Paper (+18.0%), with each lift shown.

Anchor???+21.1%4 runsOddly Smooth Stone+19.3%9 runsJoss Paper+18.0%5 runsRainbow Ring+18.0%6 runsDolly's Mirror+18.0%5 runsVenerable Tea Set???+17.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genetic Algorithm Card Details

A 1-energy rare skill, Genetic Algorithm is upgraded 15.0% of the time and tends to enter the deck around floor 15.

Gain Block. Permanently increase this card's Block by.

What Ends Runs with Genetic Algorithm

Runs holding Genetic Algorithm end most often against Queen Boss (11.1%), Kaiser Crab Boss (5.6%), and Decimillipede Elite (5.6%) — the share of its runs each accounts for is shown.

• Queen Boss11.1% of runs
• Kaiser Crab Boss5.6% of runs
• Decimillipede Elite5.6% of runs
• Aeonglass Boss5.6% of runs
• Infested Prisms Elite3.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.