Omnislice Attack

Is Omnislice good in Slay the Spire 2?

In Slay the Spire 2, Omnislice is an uncommon attack from the Colorless card pool. Its effect: Deal 8 damage. Damage ALL other enemies equal to the damage dealt. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 241 tracked runs its win rate sits at 24.1%, 10.3% ahead of the 13.8% all-deck baseline. It sees niche play, included in only 1.1% of eligible runs. When it is actually offered players take it 4.4% of the time, and that looks correct: those runs win 35.9% against 26.9% for runs that passed, a +7.2% pick lift over 39 decided runs. Within Regent runs it’s drafted 1.1% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Slice, which lifts its win rate by +18.7% when the two share a deck. On the relic side, Anchor is its standout companion, worth a +26.8% win-rate swing alongside it. It costs 0 energy, gets upgraded 24.7% of the time, and tends to be picked up near floor 15.

Upgrading the card adds +3 Damage to its stat line. Of the runs that drafted it, 57 ended in victory against 179 deaths and 5 abandons. Its most common run-ender is Queen Boss, finishing 6.2% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Omnislice fits a Colorless deck.

Pick or Skip: Omnislice

Players take Omnislice in 4.4% of the 907 offers it appears in; those runs win 35.9% against 26.9% for runs that passed, a pick lift of +7.2% over 39 decided runs.

Taken 40 times out of 907 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Omnislice

Of the 3 pickup windows recorded for Omnislice, Act 3 is the best: 54.8% across 32 runs.

Win rate of runs by the act Omnislice entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Omnislice

Omnislice’s strongest card pairings so far are Slice (+18.7%), Prepared (+17.2%), and Backflip (+13.5%), each shown with the win-rate lift it adds.

Slice+18.7%19 runsPrepared+17.2%20 runsBackflip+13.5%23 runsDefy+13.1%18 runsReflect+12.1%16 runsGather Light+11.8%20 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Omnislice Win Rate by Class

Of the 5 classes that draft Omnislice, it performs best with Regent (37.1%), Necrobinder (29.7%), and Silent (27.8%).

The Regent37.1%36 runsThe Necrobinder29.7%37 runsThe Silent27.8%55 runsThe Defect17.0%48 runsThe Ironclad16.1%64 runs

Best Relics for Omnislice

The relics that swing Omnislice’s win rate the most are Anchor (+26.8%), Tiny Mailbox (+23.9%), and Festive Popper (+23.9%), with each lift shown.

Anchor+26.8%37 runsTiny Mailbox+23.9%21 runsFestive Popper+23.9%46 runsOddly Smooth Stone+23.8%45 runsBag of Marbles+23.2%32 runsLord's Parasol+22.1%19 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Omnislice Card Details

A 0-energy uncommon attack, Omnislice is upgraded 24.7% of the time and tends to enter the deck around floor 15.

Deal 8 damage. Damage ALL other enemies equal to the damage dealt.

Upgrade: +3 Damage

What Ends Runs with Omnislice

Runs holding Omnislice end most often against Queen Boss (6.2%), Decimillipede Elite (5.8%), and Infested Prisms Elite (5.4%) — the share of its runs each accounts for is shown.

• Queen Boss6.2% of runs
• Decimillipede Elite5.8% of runs
• Infested Prisms Elite5.4% of runs
• Test Subject Boss5.4% of runs
• Knowledge Demon Boss5.0% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.