Omnislice•Attack

Is Omnislice good in Slay the Spire 2?

In Slay the Spire 2, Omnislice is an uncommon attack from the Colorless card pool. Its effect: Deal 8 damage. Damage ALL other enemies equal to the damage dealt. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 49 tracked runs its win rate sits at 35.7%, 16.8% ahead of the 18.9% all-deck baseline. It sees niche play, included in only 1.3% of eligible runs. Within Ironclad runs it’s drafted 1.6% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Shrug It Off, which lifts its win rate by +14.8% when the two share a deck. On the relic side, Anchor is its standout companion, worth a +23.0% win-rate swing alongside it. It costs 0 energy, gets upgraded 18.0% of the time, and tends to be picked up near floor 18.

Upgrading the card adds +3 Damage to its stat line. Of the runs that drafted it, 15 ended in victory against 27 deaths and 7 abandons. Its most common run-ender is The Insatiable Boss, finishing 6.1% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Omnislice fits a Colorless deck.

Best Cards to Pair with Omnislice

Omnislice’s strongest card pairings so far are Shrug It Off (+14.8%), Slice (+14.8%), and Master of Strategy (+14.8%), each shown with the win-rate lift it adds.

Shrug It Off+14.8%4 runsSlice+14.8%3 runsMaster of Strategy+14.8%4 runsPyre+14.8%5 runsBloodletting+14.8%5 runsAccuracy+11.6%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Omnislice Win Rate by Class

Of the 5 classes that draft Omnislice, it performs best with Ironclad (44.4%), Necrobinder (37.5%), and Silent (36.4%).

The Ironclad44.4%11 runsThe Necrobinder37.5%8 runsThe Silent36.4%11 runsThe Defect33.3%7 runsThe Regent25.0%12 runs

Best Relics for Omnislice

The relics that swing Omnislice’s win rate the most are Anchor (+23.0%), Festive Popper (+19.9%), and Pendulum (+19.9%), with each lift shown.

Anchor+23.0%8 runsFestive Popper+19.9%9 runsPendulum+19.9%9 runsRazor Tooth+18.4%4 runsBronze Scales+17.9%7 runsTiny Mailbox+17.9%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Omnislice Card Details

A 0-energy uncommon attack, Omnislice is upgraded 18.0% of the time and tends to enter the deck around floor 18.

Deal 8 damage. Damage ALL other enemies equal to the damage dealt.

Upgrade: +3 Damage

What Ends Runs with Omnislice

Runs holding Omnislice end most often against The Insatiable Boss (6.1%), Knowledge Demon Boss (6.1%), and Infested Prisms Elite (6.1%) — the share of its runs each accounts for is shown.

• The Insatiable Boss6.1% of runs
• Knowledge Demon Boss6.1% of runs
• Infested Prisms Elite6.1% of runs
• Queen Boss4.1% of runs
• Hunter Killer Normal4.1% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.