Poisoned Stab•Attack

Is Poisoned Stab good in Slay the Spire 2?

Poisoned Stab is a common Silent attack in Slay the Spire 2. In combat it resolves as: Deal 6 damage. Apply 3 Poison. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 14 recorded runs, decks running it win 18.2% of the time, comfortably clear of the 12.6% average, by 5.6%. It’s a more selective pick, turning up in just 2.7% of decks that could run it. Silent players keep it in 13.5% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Bouncing Flask — together they post a +31.8% swing in win rate. It also has strong chemistry with the relic Neow's Bones, which moves its win rate by +31.8%. At 1 energy, it’s upgraded in 20.0% of runs and usually joins the deck around floor 10.

Upgraded, it gains +2 Damage, +1 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 2 wins, 9 deaths, and 3 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Mecha Knight Elite, which closes out 14.3% of its appearances. Read on for Poisoned Stab’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Poisoned Stab

Ranked by win-rate lift, Poisoned Stab performs best alongside Bouncing Flask (+31.8%), Flechettes (+31.8%), and Ricochet (+15.2%).

Bouncing Flask+31.8%4 runsFlechettes+31.8%3 runsRicochet+15.2%3 runsSnakebite+15.2%4 runsUntouchable+15.2%4 runsDeadly Poison+6.8%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Win Rate by Class

Poisoned Stab is drafted only by the Silent, where it holds a 18.2% win rate across 14 runs.

The Silentappears in 13.5% of its runs (14 tracked)

Best Relics for Poisoned Stab

Poisoned Stab pairs best with the relics Neow's Bones (+31.8%), Red Mask (+21.8%), and Ring of the Snake (+1.8%), ranked by win-rate lift.

Neow's Bones+31.8%3 runsRed Mask+21.8%5 runsRing of the Snake+1.8%13 runsAnchor-18.2%3 runsSword of Stone-18.2%4 runsNew Leaf-18.2%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Card Details

Poisoned Stab is a common attack costing 1 energy; it’s upgraded in 20.0% of runs and usually picked up by floor 10.

Deal 6 damage. Apply 3 Poison.

Upgrade: +2 Damage, +1 Poison

What Ends Runs with Poisoned Stab

Poisoned Stab’s most common run-enders are Mecha Knight Elite (14.3%).

• Mecha Knight Elite14.3% of runs

See Also

Compare Poisoned Stab with the rest of the best Slay the Spire 2 cards, relics, and classes below.