Poisoned Stab Attack

Is Poisoned Stab good in Slay the Spire 2?

Poisoned Stab is a common Silent attack in Slay the Spire 2. In combat it resolves as: Deal 6 damage. Apply 3 Poison. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 823 recorded runs, decks running it win 18.1% of the time, comfortably clear of the 13.8% average, by 4.3%. It’s a more selective pick, turning up in just 3.9% of decks that could run it. Taken in 16.8% of its offers, it still trails on the pick-versus-skip split: 17.0% for runs that took it against 25.9% for runs that left it, a -8.7% pick lift over 682 decided runs. Silent players keep it in 17.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.3 times in the decks that take it.

It performs best next to Flanking — together they post a +26.1% swing in win rate. It also has strong chemistry with the relic Miniature Tent, which moves its win rate by +36.9%. At 1 energy, it’s upgraded in 23.7% of runs and usually joins the deck around floor 10.

Upgraded, it gains +2 Damage, +1 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 148 wins, 670 deaths, and 5 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Kaiser Crab Boss, which closes out 4.9% of its appearances. Read on for Poisoned Stab’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Pick or Skip: Poisoned Stab

Out of 5029 recorded offers Poisoned Stab is taken 16.8% of the time, and taking it is worth -8.7% in pick lift — 17.0% for runs that picked it against 25.9% for runs that skipped, across 682 decided runs.

Taken 843 times out of 5029 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Poisoned Stab

Poisoned Stab is strongest when it joins the deck in Act 3, where runs win 43.6% across 39 runs — one of 4 recorded pickup windows.

Win rate of runs by the act Poisoned Stab entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Poisoned Stab

Ranked by win-rate lift, Poisoned Stab performs best alongside Flanking (+26.1%), Finesse (+24.1%), and Malaise (+20.9%).

Flanking+26.1%28 runsFinesse+24.1%18 runsMalaise+20.9%29 runsSneaky+18.0%31 runsBlade of Ink+17.8%48 runsAdrenaline+17.1%106 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Win Rate by Class

Poisoned Stab is drafted only by the Silent, where it holds a 17.9% win rate across 813 runs.

The Silentappears in 17.3% of its runs (813 tracked)

Best Relics for Poisoned Stab

Poisoned Stab pairs best with the relics Miniature Tent (+36.9%), Snecko Skull (+32.3%), and Beating Remnant (+29.5%), ranked by win-rate lift.

Miniature Tent+36.9%26 runsSnecko Skull+32.3%71 runsBeating Remnant+29.5%19 runsLord's Parasol+29.5%19 runsTiny Mailbox+28.1%35 runsBellows+27.8%31 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Card Details

Poisoned Stab is a common attack costing 1 energy; it’s upgraded in 23.7% of runs and usually picked up by floor 10.

Deal 6 damage. Apply 3 Poison.

Upgrade: +2 Damage, +1 Poison

What Ends Runs with Poisoned Stab

Poisoned Stab’s most common run-enders are Kaiser Crab Boss (4.9%), Decimillipede Elite (4.9%), and Knowledge Demon Boss (4.7%).

• Kaiser Crab Boss4.9% of runs
• Decimillipede Elite4.9% of runs
• Knowledge Demon Boss4.7% of runs
• Aeonglass Boss4.7% of runs
• Queen Boss4.0% of runs

See Also

Compare Poisoned Stab with the rest of the best Slay the Spire 2 cards, relics, and classes below.