Poisoned Stab•Attack

Is Poisoned Stab good in Slay the Spire 2?

Poisoned Stab is a common Silent attack in Slay the Spire 2. In combat it resolves as: Deal 6 damage. Apply 3 Poison. It currently underperforms most alternatives, sitting at F tier in our Slay the Spire 2 card rankings.

Across 154 recorded runs, decks running it win 16.7% of the time, trailing the 19.0% average by 2.3%. It’s a more selective pick, turning up in just 4.1% of decks that could run it. Silent players keep it in 15.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.3 times in the decks that take it.

It performs best next to Reflex — together they post a +22.7% swing in win rate. It also has strong chemistry with the relic Miniature Tent, which moves its win rate by +25.0%. At 1 energy, it’s upgraded in 22.6% of runs and usually joins the deck around floor 9.

Upgraded, it gains +2 Damage, +1 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 22 wins, 110 deaths, and 22 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 6.5% of its appearances. Read on for Poisoned Stab’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Poisoned Stab

Ranked by win-rate lift, Poisoned Stab performs best alongside Reflex (+22.7%), Tactician (+20.1%), and Follow Through (+16.7%).

Reflex+22.7%14 runsTactician+20.1%21 runsFollow Through+16.7%8 runsBlade of Ink+16.7%8 runsSpeedster+16.7%13 runsStorm of Steel+16.7%12 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Win Rate by Class

Poisoned Stab is drafted only by the Silent, where it holds a 16.7% win rate across 154 runs.

The Silentappears in 15.7% of its runs (154 tracked)

Best Relics for Poisoned Stab

Poisoned Stab pairs best with the relics Miniature Tent (+25.0%), Gorget (+24.2%), and Blood Vial (+22.2%), ranked by win-rate lift.

Miniature Tent+25.0%6 runsGorget+24.2%22 runsBlood Vial+22.2%20 runsSnecko Skull+21.7%11 runsRoyal Stamp+21.1%5 runsTiny Mailbox+20.4%8 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Poisoned Stab Card Details

Poisoned Stab is a common attack costing 1 energy; it’s upgraded in 22.6% of runs and usually picked up by floor 9.

Deal 6 damage. Apply 3 Poison.

Upgrade: +2 Damage, +1 Poison

What Ends Runs with Poisoned Stab

Poisoned Stab’s most common run-enders are Knowledge Demon Boss (6.5%), Queen Boss (5.8%), and Kaiser Crab Boss (5.8%).

• Knowledge Demon Boss6.5% of runs
• Queen Boss5.8% of runs
• Kaiser Crab Boss5.8% of runs
• The Kin Boss4.5% of runs
• The Insatiable Boss3.2% of runs

See Also

Compare Poisoned Stab with the rest of the best Slay the Spire 2 cards, relics, and classes below.