Caitlyn - League of Legends Champion
Win Rate
49.3%
Pick Rate
9.9%

CaitlynRunes

DMarksman
Patch26.5
Matches4,681,645
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 19, 2026
MethodologyData Methodology

Best Caitlyn runes for LoL Patch 26.5 - Lethal Tempo from the Precision tree with Domination secondary (66.7% WR, 0.1% pick rate). Caitlyn's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down. Secondary tree: Ultimate Hunter, Cheap Shot.

Caitlyn performs best with Lethal Tempo as the keystone rune from the Precision tree. Caitlyn's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down. Caitlyn's secondary rune tree is Domination with Ultimate Hunter, Cheap Shot. This rune setup achieves a 66.67% win rate (+17.4% win rate difference) with a 0.1% pick rate across 24 Caitlyn games.
66.7%Win Rate
+17.4%WR Diff
0.1%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Legend: BloodlineLegend: Bloodline

Gain 0.45% Life Steal for every Legend stack (max 15 stacks). At maximum Legend stacks, gain 85 max health.

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Cut DownCut Down

Deal 8% more damage to champions who have more than 60% health.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

This alternative Caitlyn rune build uses Lethal Tempo as the keystone from the Precision tree. The primary runes are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down. Caitlyn's secondary rune tree is Inspiration with Triple Tonic, Cash Back. This setup achieves a 65.79% win rate (+16.5% win rate difference) with a 0.2% pick rate across 38 games.
65.8%Win Rate
+16.5%WR Diff
0.2%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Legend: BloodlineLegend: Bloodline

Gain 0.45% Life Steal for every Legend stack (max 15 stacks). At maximum Legend stacks, gain 85 max health.

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Cut DownCut Down

Deal 8% more damage to champions who have more than 60% health.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

These champions share at least 4 runes with Caitlyn's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Caitlyn's playstyle or want to learn champions with familiar rune setups.Xayah, Kai'Sa, Jinx, Draven, Ezreal and 3 others

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Caitlyn Runes - Frequently Asked Questions

What are the best Caitlyn runes in patch 26.5?

The best Caitlyn runes in patch 26.5 use the Precision tree with Lethal Tempo, Presence of Mind, Legend: Bloodline, and Cut Down, and the Domination tree with Ultimate Hunter and Cheap Shot. This rune setup achieves a 66.7% win rate with a 0.1% pick rate.

What is the win rate for Caitlyn's best rune page?

Caitlyn's best rune page has a 66.7% win rate in patch 26.5, which is +17.4% compared to Caitlyn's average win rate. This rune setup has a 0.1% pick rate among Caitlyn players.

What keystone should I use on Caitlyn?

Lethal Tempo from the Precision tree is the best keystone rune for Caitlyn in patch 26.5. This keystone synergizes well with Caitlyn's kit and provides a 66.7% win rate.

What is Caitlyn's primary rune tree?

Caitlyn's primary rune tree is Precision. The optimal Precision runes for Caitlyn are Lethal Tempo, Presence of Mind, Legend: Bloodline, and Cut Down, with Lethal Tempo being the keystone of choice.

What is Caitlyn's secondary rune tree?

Caitlyn's best secondary rune tree is Domination. The recommended Domination runes are Ultimate Hunter and Cheap Shot, which complement Caitlyn's Precision primary tree.

What are alternative rune setups for Caitlyn?

An alternative Caitlyn rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Caitlyn's runes?

Caitlyn's top rune page has a 0.1% pick rate in patch 26.5. This indicates that 0.1% of Caitlyn players use the Lethal Tempo setup with Precision and Domination trees.