Exterminate Attack

Is Exterminate good in Slay the Spire 2?

Exterminate is an event Event attack in Slay the Spire 2. In combat it resolves as: Deal 3 damage times to ALL enemies. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 448 recorded runs, decks running it win 26.2% of the time, comfortably clear of the 13.8% average, by 12.4%. It’s a more selective pick, turning up in just 2.1% of decks that could run it. Silent players keep it in 2.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Acrobatics — together they post a +22.6% swing in win rate. It also has strong chemistry with the relic Fragrant Mushroom, which moves its win rate by +31.0%. At 1 energy, it’s upgraded in 15.3% of runs and usually joins the deck around floor 23.

Upgraded, it gains +1 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 117 wins, 329 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Kaiser Crab Boss, which closes out 8.9% of its appearances. Read on for Exterminate’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Event run.

When to Pick Up Exterminate

Exterminate is strongest when it joins the deck in Act 2, where runs win 26.2% across 448 runs — one of 1 recorded pickup windows.

Win rate of runs by the act Exterminate entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Exterminate

Ranked by win-rate lift, Exterminate performs best alongside Acrobatics (+22.6%), Sucker Punch (+22.4%), and Abrasive (+22.4%).

Acrobatics+22.6%22 runsSucker Punch+22.4%18 runsAbrasive+22.4%18 runsMad Science+22.3%49 runsAshen Strike+20.3%15 runsLeg Sweep+20.3%15 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Exterminate Win Rate by Class

Exterminate is played across 5 classes, led by Silent (34.4%), Regent (28.8%), and Necrobinder (26.0%) by win rate.

The Silent34.4%93 runsThe Regent28.8%66 runsThe Necrobinder26.0%73 runsThe Ironclad24.3%112 runsThe Defect18.8%102 runs

Best Relics for Exterminate

Exterminate pairs best with the relics Fragrant Mushroom (+31.0%), Jeweled Mask (+30.0%), and Cloak Clasp (+24.3%), ranked by win-rate lift.

Fragrant Mushroom+31.0%33 runsJeweled Mask+30.0%16 runsCloak Clasp+24.3%15 runsGame Piece+24.1%25 runsThe Courier+22.3%16 runsJoss Paper+21.1%23 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Exterminate Card Details

Exterminate is an event attack costing 1 energy; it’s upgraded in 15.3% of runs and usually picked up by floor 23.

Deal 3 damage times to ALL enemies.

Upgrade: +1 Damage

What Ends Runs with Exterminate

Exterminate’s most common run-enders are Kaiser Crab Boss (8.9%), Test Subject Boss (8.3%), and Knowledge Demon Boss (8.3%).

• Kaiser Crab Boss8.9% of runs
• Test Subject Boss8.3% of runs
• Knowledge Demon Boss8.3% of runs
• The Insatiable Boss7.1% of runs
• Queen Boss6.0% of runs

See Also

Compare Exterminate with the rest of the best Slay the Spire 2 cards, relics, and classes below.