ExterminateAttack
Deal 3 damage times to ALL enemies.
Is Exterminate good in Slay the Spire 2?
Exterminate is an event Event attack in Slay the Spire 2. In combat it resolves as: Deal 3 damage times to ALL enemies. It ranks among the strongest cards its class can draft right now, earning a spot at S tier in our Slay the Spire 2 card tier list.
Across 5 recorded runs, decks running it win 60.0% of the time, comfortably clear of the 12.6% average, by 47.4%. It’s a more selective pick, turning up in just 1.0% of decks that could run it. Ironclad players keep it in 2.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.
It performs best next to Ascender's Bane — together they post a +40.0% swing in win rate. It also has strong chemistry with the relic Stone Cracker, which moves its win rate by +6.7%. At 1 energy, it’s upgraded in 40.0% of runs and usually joins the deck around floor 23.
Upgraded, it gains +1 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 3 wins, 2 deaths, and 0 abandoned runs with it in the deck. Read on for Exterminate’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Event run.
Exterminate Win Rate & Pick Rate
Exterminate’s 60.0% win rate clears the 12.6% all-deck average by 47.4%, the gap charted below.
Run Outcomes with Exterminate
Exterminate has 3 wins and 2 losses over 5 tracked runs (60.0% won); abandoned runs count as losses.
- Wins 60.0%
- Losses 40.0%
Best Cards to Pair with Exterminate
Ranked by win-rate lift, Exterminate performs best alongside Ascender's Bane (+40.0%).
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Exterminate Win Rate by Class
Exterminate is played across 4 classes, led by Ironclad (100.0%), Regent (100.0%), and Necrobinder (50.0%) by win rate.
Best Relics for Exterminate
Exterminate pairs best with the relics Stone Cracker (+6.7%) and Regal Pillow (+6.7%), ranked by win-rate lift.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Exterminate Card Details
Exterminate is an event attack costing 1 energy; it’s upgraded in 40.0% of runs and usually picked up by floor 23.
Deal 3 damage times to ALL enemies.
Upgrade: +1 Damage
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Exterminate – Frequently Asked Questions
Is Exterminate good in Slay the Spire 2?
Across 5 tracked runs, Exterminate has a 60.0% win rate — +47.4% above the average deck. Win rate reflects how often runs that include the card end in victory.
What does Exterminate do in Slay the Spire 2?
Exterminate costs 1 energy. Deal 3 damage times to ALL enemies.
What class is Exterminate in Slay the Spire 2?
Exterminate is an Event Event Attack.
Is Exterminate worth upgrading in Slay the Spire 2?
Players upgrade Exterminate in 40.0% of runs. Upgrading it grants +1 Damage.
What is the best relic for Exterminate?
In tracked runs, Exterminate has performed best alongside Stone Cracker, which lifts its win rate by +6.7% over 3 runs together.
See Also
Compare Exterminate with the rest of the best Slay the Spire 2 cards, relics, and classes below.