Exterminate•Attack

Is Exterminate good in Slay the Spire 2?

Exterminate is an event Event attack in Slay the Spire 2. In combat it resolves as: Deal 3 damage times to ALL enemies. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 76 recorded runs, decks running it win 31.9% of the time, comfortably clear of the 19.0% average, by 13.0%. It’s a more selective pick, turning up in just 2.0% of decks that could run it. Silent players keep it in 1.9% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Abrasive — together they post a +19.4% swing in win rate. It also has strong chemistry with the relic Fragrant Mushroom, which moves its win rate by +21.7%. At 1 energy, it’s upgraded in 15.4% of runs and usually joins the deck around floor 24.

Upgraded, it gains +1 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 23 wins, 49 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Test Subject Boss, which closes out 11.8% of its appearances. Read on for Exterminate’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Event run.

Best Cards to Pair with Exterminate

Ranked by win-rate lift, Exterminate performs best alongside Abrasive (+19.4%), Acrobatics (+19.3%), and Mad Science (+19.1%).

Abrasive+19.4%4 runsAcrobatics+19.3%6 runsMad Science+19.1%8 runsBlood Wall+16.0%6 runsDoubt+15.7%3 runsDash+15.7%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Exterminate Win Rate by Class

Exterminate is played across 5 classes, led by Silent (38.9%), Ironclad (33.3%), and Defect (29.4%) by win rate.

The Silent38.9%19 runsThe Ironclad33.3%16 runsThe Defect29.4%17 runsThe Necrobinder28.6%15 runsThe Regent25.0%9 runs

Best Relics for Exterminate

Exterminate pairs best with the relics Fragrant Mushroom (+21.7%), War Hammer (+19.4%), and Joss Paper (+19.3%), ranked by win-rate lift.

Fragrant Mushroom+21.7%9 runsWar Hammer+19.4%4 runsJoss Paper+19.3%6 runsCandelabra+16.4%9 runsThe Courier+16.0%5 runsTea of Discourtesy+16.0%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Exterminate Card Details

Exterminate is an event attack costing 1 energy; it’s upgraded in 15.4% of runs and usually picked up by floor 24.

Deal 3 damage times to ALL enemies.

Upgrade: +1 Damage

What Ends Runs with Exterminate

Exterminate’s most common run-enders are Test Subject Boss (11.8%), Infested Prisms Elite (6.6%), and Kaiser Crab Boss (6.6%).

• Test Subject Boss11.8% of runs
• Infested Prisms Elite6.6% of runs
• Kaiser Crab Boss6.6% of runs
• Entomancer Elite6.6% of runs
• Knowledge Demon Boss6.6% of runs

See Also

Compare Exterminate with the rest of the best Slay the Spire 2 cards, relics, and classes below.