Royal PoisonRelic
At the start of each combat, lose HP.
Is Royal Poison good in Slay the Spire 2?
Royal Poison is an event relic in Slay the Spire 2. While carried, it does the following: At the start of each combat, lose HP. It ranks among the better relics in the game right now, earning a spot at S tier in our Slay the Spire 2 relic tier list.
Across 3 recorded runs, decks carrying it win 66.7% of the time, comfortably clear of the 12.6% average, by 54.0%. It’s a more situational relic, showing up in just 0.6% of runs. The class that gets the most out of it is the Ironclad, at a 100.0% win rate. Ironclad players hold onto it in 2.0% of their runs.
On average it’s acquired around floor 42 of a run. Its event rarity shapes how frequently you’ll run into it.
It has 2 run wins against 1 losses in our tracked data. Read on for Royal Poison’s complete card, class, and threat breakdown before you decide to pick it up.
Royal Poison Win Rate & Pick Rate
Royal Poison’s 66.7% win rate clears the 12.6% all-run average by 54.0%, the gap charted below.
Run Outcomes with Royal Poison
Royal Poison has 2 wins and 1 losses over 3 tracked runs (66.7% won); abandoned runs count as losses.
- Wins 66.7%
- Losses 33.3%
Royal Poison Details
Royal Poison is an event relic carried in 0.6% of runs and usually picked up around floor 42.
At the start of each combat, lose HP.
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Royal Poison – Frequently Asked Questions
Is Royal Poison good in Slay the Spire 2?
Across 3 tracked runs carrying it, Royal Poison wins 66.7% of the time — +54.0% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Royal Poison do in Slay the Spire 2?
At the start of each combat, lose HP.
How rare is Royal Poison in Slay the Spire 2?
Royal Poison is an Event relic, picked up in 0.6% of tracked runs.
Which class is Royal Poison best in?
Royal Poison has its highest win rate with The Ironclad (100.0%).
See Also
Compare Royal Poison with the rest of the best Slay the Spire 2 relics, cards, and classes below.