Royal PoisonRelic
At the start of each combat, lose HP.
Is Royal Poison good in Slay the Spire 2?
Royal Poison is an event relic in Slay the Spire 2. While carried, it does the following: At the start of each combat, lose HP. It ranks among the better relics in the game right now, earning a spot at S tier in our Slay the Spire 2 relic tier list.
Across 15 recorded runs, decks carrying it win 71.4% of the time, comfortably clear of the 19.0% average, by 52.5%. It’s a more situational relic, showing up in just 0.4% of runs. The class that gets the most out of it is the Necrobinder, at a 100.0% win rate. Necrobinder players hold onto it in 0.4% of their runs.
It combos especially well with Bodyguard, worth a +28.6% win-rate swing together. Another strong card to run with it is Strike, worth +28.6% to its win rate. On average it’s acquired around floor 40 of a run. Its event rarity shapes how frequently you’ll run into it.
It has 10 run wins against 4 losses in our tracked data. Read on for Royal Poison’s complete card, class, and threat breakdown before you decide to pick it up.
Royal Poison Win Rate & Pick Rate
Royal Poison’s 71.4% win rate clears the 19.0% all-run average by 52.5%, the gap charted below.
Run Outcomes with Royal Poison
Royal Poison has 10 wins and 5 losses over 15 tracked runs (66.7% won); abandoned runs count as losses.
- Wins 66.7%
- Losses 33.3%
Royal Poison Win Rate by Class
Royal Poison shows up across 4 classes, led by Necrobinder (100.0%), Regent (100.0%), and Ironclad (66.7%) by win rate.
Royal Poison Details
Royal Poison is an event relic carried in 0.4% of runs and usually picked up around floor 40.
At the start of each combat, lose HP.
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Royal Poison – Frequently Asked Questions
Is Royal Poison good in Slay the Spire 2?
Across 15 tracked runs carrying it, Royal Poison wins 71.4% of the time — +52.5% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Royal Poison do in Slay the Spire 2?
At the start of each combat, lose HP.
How rare is Royal Poison in Slay the Spire 2?
Royal Poison is an Event relic, picked up in 0.4% of tracked runs.
What is the best card to use with Royal Poison?
In tracked runs, Royal Poison has performed best alongside Bodyguard, which lifts its win rate by +28.6% over 3 runs together.
Which class is Royal Poison best in?
Royal Poison has its highest win rate with The Necrobinder (100.0%).
See Also
Compare Royal Poison with the rest of the best Slay the Spire 2 relics, cards, and classes below.