- Win Rate
- 50.7%
- Pick Rate
- 0.9%
- Ban Rate
- 0.9%
Annie Mid Runes: Keystone & Shards
- Patch
- 26.21
- Games
- 1,808
- Lane
- Mid
- Tier
- All Tiers
- Last Updated
- Nov 3, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Best Mid Annie runes for LoL Patch 26.21 - Electrocute from the Domination tree with Sorcery secondary (50.5% WR, 47.7% pick rate). Annie's optimal primary runes are Electrocute, Cheap Shot, Grisly Mementos, Relentless Hunter. Secondary tree: Absolute Focus, Axiom Arcanist.
Primary Tree
Domination
ElectrocuteHitting a champion with 3 separate attacks or abilities within 3s deals bonus
Damage: 70 - 240 (+0.1 bonus AD, +0.05 AP) damage.
Cooldown: 20s
'We called them the Thunderlords, for to speak of their lightning was to invite disaster.'
Cheap ShotDamaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).
Cooldown: 4s
Grisly MementosCollect 1 memento on champion
Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.
Relentless HunterGain
Absolute FocusWhile above 70% health, gain an
Grants 1.8 Attack Damage or 3 Ability Power at level 1.
Axiom ArcanistYour Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)
Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.
Primary Tree
Sorcery
Deathfire TouchDamaging a champion with an ability burns them for 3 - 12 based on level (+
Duration:
Single Target: 4s
Area of Effect: 2s
Damage over Time: 1s
Manaflow BandHitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.
After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.
Cooldown: 15 seconds
CelerityAll movement bonuses are 7% more effective on you and gain
ScorchYour next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.
Cooldown: 10s
Cut DownDeal 8% more damage to champions who have more than 60% health.
Legend: HasteGain 1.5 basic ability haste for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Every Annie Mid Keystone and Secondary Tree (Patch 26.21)
1,735 gamesAnnie Mid runs Electrocute in 81% of games, with a 50.3% win rate. Sorcery is the usual secondary tree (72%). Standard stat shards: Adaptive Force (offense), Adaptive Force (flex), Health Scaling (defense).
Keystones
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| ElectrocuteMost played | 81.5% | 50.3% | 1,414 |
| Deathfire Touch | 14.7% | 52.9% | 255 |
Secondary trees
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| SorceryMost played | 71.8% | 51.1% | 1,245 |
 Precision | 13.8% | 51.7% | 240 |
 Inspiration | 10.9% | 43.9% | 189 |
Pick rate is the share of Annie games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.
Annie Minor Runes by Tree
Every minor rune Annie players take, grouped by rune tree, with how often it is picked and how often it wins.
Domination
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Cheap ShotMost played | 80.9% | 49.7% | 1,403 |
| Grisly Mementos | 80.5% | 49.9% | 1,396 |
| Relentless Hunter | 65.6% | 50.8% | 1,139 |
 Ultimate Hunter | 18.3% | 47.9% | 317 |
 Taste of Blood | 3.4% | 66.1% | 59 |
Sorcery
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Axiom ArcanistMost played | 68.1% | 50.7% | 1,181 |
| Absolute Focus | 65.2% | 50.8% | 1,131 |
| Scorch | 18.2% | 51.6% | 316 |
| Manaflow Band | 17.6% | 55.6% | 306 |
| Celerity | 15.2% | 52.9% | 263 |
 Transcendence | 3.3% | 65.5% | 58 |
Precision
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Legend: HasteMost played | 13.0% | 52.2% | 226 |
| Cut Down | 12.3% | 51.9% | 214 |
Inspiration
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Cosmic InsightMost played | 10.8% | 42.6% | 188 |
 Biscuit Delivery | 9.6% | 40.7% | 167 |
Annie Stat Shards
Which stat shards Annie players choose in each of the three shard rows, and the win rate of each.
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Adaptive Force (flex)Most played | 84.8% | 50.4% | 1,471 |
 Health Scaling (defense) | 79.1% | 50.4% | 1,372 |
| Adaptive Force (offense) | 72.8% | 51.5% | 1,263 |
 Attack Speed (offense) | 24.6% | 47.8% | 427 |
| Health (defense) | 17.2% | 51.0% | 298 |
 Move Speed (flex) | 15.0% | 52.7% | 260 |
 Tenacity and Slow Resist (defense) | 3.7% | 55.4% | 65 |
 Ability Haste (offense) | 2.6% | 57.8% | 45 |
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Annie Runes FAQ - Patch 26.21
What is the best keystone for Annie Mid?
Electrocute: Annie Mid takes it in 81% of ranked games and wins 50.3% of 1,414 games. Alternatives: Deathfire Touch (15%, 52.9%).
What stat shards should Annie take?
Most Annie players take Adaptive Force (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.
What are the best Annie runes in patch 26.21?
The best Annie runes in patch 26.21 use the Domination tree with Electrocute, Cheap Shot, Grisly Mementos, and Relentless Hunter, and the Sorcery tree with Absolute Focus and Axiom Arcanist. This rune setup achieves a 50.5% win rate with a 47.7% pick rate.
What is the win rate for Annie's best rune page?
Annie's best rune page has a 50.5% win rate in patch 26.21, which is -0.2% compared to Annie's average win rate. This rune setup has a 47.7% pick rate among Annie players.
What keystone should I use on Annie?
Electrocute from the Domination tree is the best keystone rune for Annie in patch 26.21. This keystone synergizes well with Annie's kit and provides a 50.5% win rate.
What is Annie's primary rune tree?
Annie's primary rune tree is Domination. The optimal Domination runes for Annie are Electrocute, Cheap Shot, Grisly Mementos, and Relentless Hunter, with Electrocute being the keystone of choice.
What is Annie's secondary rune tree?
Annie's best secondary rune tree is Sorcery. The recommended Sorcery runes are Absolute Focus and Axiom Arcanist, which complement Annie's Domination primary tree.
What are alternative rune setups for Annie?
An alternative Annie rune setup uses Deathfire Touch from the Sorcery tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Annie's runes?
Annie's top rune page has a 47.7% pick rate in patch 26.21. This indicates that 47.7% of Annie players use the Electrocute setup with Domination and Sorcery trees.