
Cassiopeiavs Seraphine
Cassiopeia vs Seraphine is a decisive matchup in LoL patch 26.9. Seraphine wins with a 66.7% win rate (+33.3%) over Cassiopeia based on 6 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Seraphine matchup.
Cassiopeia Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Cassiopeia vs Seraphine Matchup?

Cassiopeia vs Seraphine Matchup Summary
The Cassiopeia vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Seraphine wins with a 66.7% win rate compared to Cassiopeia's 33.3%, giving Seraphine a 33.3 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Cassiopeia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Cassiopeia leads by 348 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Cassiopeia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Cassiopeia vs Seraphine Laning Phase Breakdown
Seraphine is favored during the laning phase against Cassiopeia, winning 3 out of 5 key stat categories. Seraphine holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Best Cassiopeia Build Against Seraphine
Spellslinger's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Cassiopeia needs most in this matchup. The top-performing core items for Cassiopeia against Seraphine are Liandry's Torment, Rylai's Crystal Scepter and Blackfire Torch. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Cassiopeia vs Seraphine matchup.
Early Game vs Late Game
Seraphine dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Cassiopeia. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Seraphine is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Cassiopeia. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.
Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Cassiopeia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Cassiopeia Runes Against Seraphine
The Sorcery and Precision rune setup gives Cassiopeia the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Cassiopeia matchup data for League of Legends patch 26.9. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 47.37% | 38 | 6.8 | 724 | 11,436 | 50.0% | 44.4% | |
| 48.48% | 33 | 6.5 | 801 | 12,214 | 50.0% | 47.1% | |
| 46.43% | 28 | 6.5 | 709 | 11,643 | 58.3% | 37.5% | |
| 48.15% | 27 | 6.9 | 827 | 11,849 | 54.5% | 43.8% | |
| 53.85% | 26 | 6.8 | 796 | 12,651 | 62.5% | 50.0% | |
| 45.83% | 24 | 6.4 | 873 | 12,400 | 50.0% | 43.8% | |
| 59.09% | 22 | 6.9 | 957 | 10,000 | 64.3% | 50.0% | |
| 47.62% | 21 | 6.5 | 918 | 12,316 | 50.0% | 46.1% | |
| 42.11% | 19 | 6.4 | 873 | 11,643 | 77.8% | 10.0% | |
| 36.84% | 19 | 6.9 | 790 | 13,546 | 20.0% | 42.9% | |
| 42.11% | 19 | 7.1 | 839 | 11,347 | 38.5% | 50.0% | |
| 57.89% | 19 | 7.0 | 1,117 | 10,299 | 58.3% | 57.1% | |
| 62.50% | 16 | 7.6 | 917 | 12,350 | 80.0% | 33.3% | |
| 40.00% | 15 | 6.8 | 733 | 9,766 | 14.3% | 62.5% | |
| 33.33% | 15 | 6.7 | 714 | 10,848 | 22.2% | 50.0% | |
| 46.67% | 15 | 6.9 | 873 | 12,407 | 62.5% | 28.6% | |
| 60.00% | 15 | 5.7 | 923 | 10,356 | 50.0% | 66.7% | |
| 53.33% | 15 | 6.3 | 853 | 12,674 | 57.1% | 50.0% | |
| 46.67% | 15 | 6.4 | 690 | 10,335 | 55.6% | 33.3% | |
| 64.29% | 14 | 6.7 | 916 | 11,984 | 50.0% | 75.0% | |
| 46.15% | 13 | 5.8 | 727 | 11,454 | 50.0% | 44.4% | |
| 50.00% | 12 | 6.7 | 857 | 10,805 | 57.1% | 40.0% | |
| 41.67% | 12 | 6.2 | 951 | 12,814 | 40.0% | 42.9% | |
| 58.33% | 12 | 6.9 | 833 | 11,580 | 100.0% | 37.5% | |
| 41.67% | 12 | 6.2 | 831 | 11,581 | 50.0% | 33.3% | |
| 50.00% | 12 | 5.8 | 820 | 12,552 | 33.3% | 55.6% | |
| 41.67% | 12 | 7.4 | 916 | 11,832 | 42.9% | 40.0% | |
| 36.36% | 11 | 7.4 | 863 | 12,272 | 33.3% | 40.0% | |
| 63.64% | 11 | 6.5 | 1,009 | 14,340 | 66.7% | 60.0% | |
| 54.55% | 11 | 5.7 | 721 | 11,869 | 40.0% | 66.7% | |
| 72.73% | 11 | 7.0 | 1,129 | 13,391 | 75.0% | 71.4% | |
| 36.36% | 11 | 6.4 | 820 | 12,003 | 66.7% | 25.0% | |
| 40.00% | 10 | 6.5 | 712 | 9,624 | 42.9% | 33.3% | |
| 50.00% | 10 | 6.8 | 1,216 | 13,824 | 66.7% | 42.9% | |
| 20.00% | 10 | 6.3 | 990 | 11,552 | 33.3% | 0.0% | |
| 40.00% | 10 | 6.6 | 1,013 | 11,863 | 66.7% | 0.0% | |
| 50.00% | 10 | 6.0 | 789 | 12,480 | 100.0% | 37.5% | |
| 55.56% | 9 | 5.6 | 695 | 10,379 | 50.0% | 57.1% | |
| 44.44% | 9 | 6.5 | 1,063 | 15,033 | 50.0% | 42.9% | |
| 55.56% | 9 | 7.4 | 860 | 11,787 | 50.0% | 60.0% | |
| 66.67% | 9 | 6.8 | 854 | 12,062 | 100.0% | 40.0% | |
| 62.50% | 8 | 7.1 | 896 | 13,348 | 60.0% | 66.7% | |
| 87.50% | 8 | 5.9 | 1,023 | 13,022 | 100.0% | 80.0% | |
| 37.50% | 8 | 6.8 | 898 | 11,712 | 75.0% | 0.0% | |
| 75.00% | 8 | 6.8 | 684 | 11,301 | 100.0% | 66.7% | |
| 50.00% | 8 | 6.2 | 823 | 11,105 | 50.0% | 50.0% | |
| 57.14% | 7 | 6.3 | 638 | 8,468 | 60.0% | 50.0% | |
| 57.14% | 7 | 7.0 | 874 | 13,149 | 66.7% | 50.0% | |
| 57.14% | 7 | 6.8 | 890 | 12,765 | 100.0% | 40.0% | |
| 42.86% | 7 | 6.4 | 829 | 10,133 | 40.0% | 50.0% | |
| 71.43% | 7 | 6.1 | 697 | 11,111 | 60.0% | 100.0% | |
| 57.14% | 7 | 6.2 | 836 | 11,179 | 50.0% | 66.7% | |
| 33.33% | 6 | 6.0 | 616 | 12,102 | 0.0% | 40.0% | |
| 50.00% | 6 | 5.5 | 962 | 15,454 | 0.0% | 50.0% | |
| 83.33% | 6 | 7.3 | 987 | 13,178 | 50.0% | 100.0% | |
| 20.00% | 5 | 7.1 | 907 | 12,365 | 100.0% | 0.0% | |
| 20.00% | 5 | 6.9 | 1,081 | 9,794 | 25.0% | 0.0% | |
| 60.00% | 5 | 6.6 | 958 | 17,062 | 0.0% | 60.0% | |
| 40.00% | 5 | 5.0 | 924 | 11,058 | 100.0% | 25.0% | |
| 40.00% | 5 | 5.6 | 894 | 11,588 | 33.3% | 50.0% | |
| 40.00% | 5 | 7.6 | 583 | 10,358 | 66.7% | 0.0% | |
| 60.00% | 5 | 6.0 | 662 | 7,572 | 50.0% | 100.0% | |
| 20.00% | 5 | 6.4 | 816 | 11,448 | 50.0% | 0.0% | |
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Cassiopeia vs Seraphine - Frequently Asked Questions
How does Cassiopeia do against Seraphine in League of Legends?
Seraphine wins the Cassiopeia vs Seraphine matchup with a 66.7% win rate compared to Cassiopeia's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.9.
How does Cassiopeia do against Seraphine in the early game?
In the early game, Seraphine has the advantage against Cassiopeia with a 100.0% win rate versus 0.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Cassiopeia do against Seraphine in the late game?
In the late game, Seraphine takes over the Cassiopeia vs Seraphine matchup with a 60.0% win rate compared to 40.0%. Seraphine scales better into team fights and objective contests after 25 minutes.
Who wins the Cassiopeia vs Seraphine matchup?
Seraphine wins the matchup against Cassiopeia with a 66.7% win rate in League of Legends patch 26.9. The 33.3 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 6 games analyzed.
What is the best Cassiopeia build against Seraphine?
The best Cassiopeia build against Seraphine includes Liandry's Torment, Rylai's Crystal Scepter, Blackfire Torch with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.
What are the best Cassiopeia runes against Seraphine?
The best Cassiopeia runes against Seraphine use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.
Does Cassiopeia counter Seraphine?
No, Cassiopeia struggles against Seraphine with only a 33.3% win rate. Seraphine has the advantage in this matchup. Cassiopeia players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.
How do I play Cassiopeia against Seraphine?
When playing Cassiopeia against Seraphine, play cautiously and avoid Seraphine's power spikes. Look for jungle assistance and team-dependent plays since Seraphine has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.