Seraphine - League of Legends Champion
Win Rate
52.4%
Pick Rate
10.2%

Seraphinevs Cassiopeia

SSupportMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Seraphine vs Cassiopeia is a decisive matchup in LoL patch 26.14. Cassiopeia wins with a 77.8% win rate (+55.6%) over Seraphine based on 9 games. Cassiopeia holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Cassiopeia matchup.

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Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 22.2% win rate in this matchup
Seraphine
22.2% WR
VS
Cassiopeia vs Seraphine matchup - 77.8% win rate
Cassiopeia
77.8% WR

Who Wins the Seraphine vs Cassiopeia Matchup?

Cassiopeia wins the Seraphine vs Cassiopeia matchup
Winner
Cassiopeia
Matches: 9
22.2%
Win Rate
77.8%
5.3
CS / min
6.0
749
DMG / min
864
11,248
Gold / game
13,088
106
Heal / min
327
407
DMG Mitigated / min
511
1.1
CC / min
1.3
0.0%
Early Game WR
100.0%
28.6%
Late Game WR
71.4%

Seraphine vs Cassiopeia Matchup Summary

The Seraphine vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Cassiopeia wins with a 77.8% win rate compared to Seraphine's 22.2%, giving Cassiopeia a 55.6 percentage point advantage. Cassiopeia dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Seraphine players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Cassiopeia leads by 324 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a strong advantage in this matchup. Seraphine players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Cassiopeia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Cassiopeia Laning Phase Breakdown

Cassiopeia wins the laning phase against Seraphine in League of Legends

Cassiopeia is favored during the laning phase against Seraphine, winning 5 out of 5 key stat categories. Cassiopeia holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
5.3Seraphine
6.0Cassiopeia
Cassiopeia edges out Seraphine by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 11 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Cassiopeia.
Damage
749Seraphine
864Cassiopeia
Cassiopeia heavily out-damages Seraphine by 115 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Cassiopeia's sustained damage advantage take over.
Economy
11,248Seraphine
13,088Cassiopeia
Cassiopeia generates a commanding 1,839 more gold per game than Seraphine. This substantial economic advantage means Cassiopeia consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Seraphine
1.3Cassiopeia
Both Seraphine and Cassiopeia provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
513Seraphine
837Cassiopeia
Cassiopeia vastly out-sustains Seraphine, healing and mitigating 324 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Seraphine is forced to recall. Building grievous wounds early is essential for Seraphine, and focusing on burst trade patterns rather than sustained fights is critical.

Best Seraphine Build Against Cassiopeia

Spellslinger's Shoes is the optimal boots choice against Cassiopeia, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Cassiopeia are Luden's Echo, Stormsurge and Imperial Mandate. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Cassiopeia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Cassiopeia matchup.

Early Game vs Late Game

Early Game
Cassiopeia
100.0%
+100.0% advantage
Seraphine early game win rateSeraphine0.0%
Cassiopeia early game win rateCassiopeia100.0%
Late Game
Cassiopeia
71.4%
+42.9% advantage
Seraphine late game win rateSeraphine28.6%
Cassiopeia late game win rateCassiopeia71.4%

Cassiopeia dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Seraphine. This lopsided early game means Cassiopeia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Cassiopeia is far superior in the late game (25+ minutes), boasting a 71.4% win rate — 42.9 points above Seraphine. Extended games heavily favor Cassiopeia, whose kit and scaling make them a dominant force in team fights and objective control.

Cassiopeia holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Seraphine players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Cassiopeia

Sorcery rune tree - Seraphine primary runes vs CassiopeiaSorcery
Deathfire Touch - best Seraphine rune vs CassiopeiaManaflow Band - best Seraphine rune vs CassiopeiaTranscendence - best Seraphine rune vs CassiopeiaScorch - best Seraphine rune vs Cassiopeia
Inspiration rune tree - Seraphine secondary runes vs CassiopeiaInspiration
Magical Footwear - best Seraphine rune vs CassiopeiaBiscuit Delivery - best Seraphine rune vs Cassiopeia
100.0% WR

The Sorcery and Inspiration rune setup gives Seraphine the best tools to compete against Cassiopeia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Seraphine matchup data for League of Legends patch 26.14. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
53.16%7111.74819,36751.5%54.1%
51.75%4291.55108,83357.1%48.3%
54.52%3981.55039,13350.3%57.6%
48.02%3791.44838,49549.1%47.1%
51.34%3721.64948,76049.7%52.5%
45.48%3541.55209,36553.0%40.9%
51.52%3301.95329,62049.6%52.7%
50.55%2731.54919,35246.5%52.9%
47.43%2531.44388,72453.5%43.5%
51.25%2401.55148,99259.8%44.9%
51.27%2361.44739,16655.6%48.6%
52.99%2341.85839,26944.9%58.8%
46.78%2331.55058,55244.9%48.4%
56.71%2312.35169,48657.0%56.6%
52.38%2101.44748,93357.8%48.8%
51.91%1831.44858,32454.5%50.0%
55.87%1791.53958,91064.0%50.0%
53.07%1795.374111,32450.0%54.8%
50.85%1771.85199,28153.6%49.1%
56.02%1661.55099,26754.0%57.6%
52.47%1625.976711,10365.7%43.2%
51.59%1571.64759,65261.7%47.3%
46.45%1551.66288,48848.0%45.1%
48.37%1531.64749,70351.2%47.3%
50.66%1521.55259,12259.6%45.3%
54.86%1441.44909,33253.6%55.7%
49.28%1381.94979,05744.2%52.3%
55.38%1301.44948,78550.0%58.8%
58.97%1171.44908,67664.0%55.2%
55.65%1151.45379,04852.2%58.0%
59.29%1131.45038,43250.0%66.2%
52.43%1031.45099,35760.0%47.6%
53.92%1024.166410,30653.9%54.0%
54.55%995.977610,62646.1%63.8%
58.06%931.64999,18554.3%60.3%
57.30%891.44918,64361.4%53.3%
63.86%836.084311,78848.6%75.0%
53.25%775.773910,90155.9%51.2%
45.21%731.94539,31152.2%42.0%
36.11%721.54988,98133.3%38.1%
57.14%701.45179,16655.6%58.1%
61.54%656.078011,06369.0%55.6%
50.00%643.86639,74768.2%40.5%
61.90%634.868910,47463.0%61.1%
47.54%612.761610,42127.3%59.0%
48.21%566.078511,47145.8%50.0%
59.62%526.181612,18757.1%61.3%
54.00%501.45608,84660.9%48.1%
48.94%471.84949,58942.9%53.9%
43.48%461.54339,57246.1%42.4%
57.78%455.372012,60925.0%64.9%
54.55%446.367711,99735.3%66.7%
61.36%441.55258,98750.0%67.9%
57.14%422.54878,58155.6%58.3%
60.98%412.15749,53475.0%52.0%
53.66%416.483312,18466.7%43.5%
55.00%401.54869,06552.9%56.5%
50.00%365.976411,05156.3%45.0%
50.00%346.183611,75042.9%55.0%
36.36%331.53968,95946.1%30.0%
66.67%335.364811,49190.9%54.5%
54.84%316.183810,19170.6%35.7%
53.57%286.580512,36836.4%64.7%
42.86%286.280112,68940.0%44.4%
40.00%255.362911,18522.2%50.0%
64.00%252.36789,31844.4%75.0%
66.67%241.34418,16983.3%50.0%
30.43%234.16229,77136.4%25.0%
54.55%225.576911,54555.6%53.9%
65.00%205.462410,76455.6%72.7%
42.11%191.75298,46820.0%66.7%
73.68%193.95989,82285.7%66.7%
58.82%171.655210,13840.0%66.7%
35.29%173.258910,24028.6%40.0%
37.50%163.75519,69033.3%40.0%
68.75%165.873111,38350.0%80.0%
31.25%164.771510,51042.9%22.2%
43.75%166.477210,43645.5%40.0%
40.00%154.44959,89250.0%36.4%
66.67%155.878113,250100.0%50.0%
66.67%152.74889,77166.7%66.7%
42.86%142.26418,95728.6%57.1%
69.23%134.356610,34966.7%71.4%
53.85%133.57288,31450.0%57.1%
46.15%133.15299,02050.0%44.4%
53.85%133.36459,24657.1%50.0%
66.67%122.057810,201100.0%55.6%
58.33%127.083213,37480.0%42.9%
66.67%122.153210,54566.7%66.7%
58.33%121.13417,53971.4%40.0%
45.45%114.96859,29462.5%0.0%
54.55%111.64597,06766.7%40.0%
54.55%113.460410,17460.0%50.0%
45.45%114.96329,44228.6%75.0%
72.73%116.378413,52975.0%71.4%
50.00%105.182912,07833.3%57.1%
70.00%104.26128,41357.1%100.0%
80.00%105.395111,600100.0%71.4%
60.00%101.55159,32450.0%62.5%
33.33%95.666611,01725.0%40.0%
44.44%93.167310,88450.0%40.0%
22.22%95.374911,2480.0%28.6%
37.50%83.170511,06950.0%33.3%
62.50%82.047510,68250.0%75.0%
50.00%81.95667,68550.0%50.0%
75.00%85.895811,97766.7%80.0%
57.14%73.050210,97250.0%60.0%
100.00%71.958610,112100.0%100.0%
100.00%72.56609,161100.0%100.0%
83.33%61.54667,90050.0%100.0%
66.67%62.069710,723100.0%33.3%
66.67%62.855510,27950.0%75.0%
33.33%65.071411,4970.0%40.0%
50.00%65.962611,0990.0%75.0%
50.00%61.36056,62633.3%66.7%
33.33%63.263711,14750.0%25.0%
40.00%51.95389,8290.0%50.0%
40.00%54.372312,2080.0%50.0%
40.00%51.132610,5150.0%40.0%
40.00%54.15138,25733.3%50.0%

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Seraphine vs Cassiopeia - Frequently Asked Questions

How does Seraphine do against Cassiopeia in League of Legends?

Cassiopeia wins the Seraphine vs Cassiopeia matchup with a 77.8% win rate compared to Seraphine's 22.2%, a 55.6 percentage point difference. This data is based on 9 recent ranked games in patch 26.14.

How does Seraphine do against Cassiopeia in the early game?

In the early game, Cassiopeia has the advantage against Seraphine with a 100.0% win rate versus 0.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Cassiopeia in the late game?

In the late game, Cassiopeia takes over the Seraphine vs Cassiopeia matchup with a 71.4% win rate compared to 28.6%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Cassiopeia matchup?

Cassiopeia wins the matchup against Seraphine with a 77.8% win rate in League of Legends patch 26.14. The 55.6 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Seraphine build against Cassiopeia?

The best Seraphine build against Cassiopeia includes Luden's Echo, Stormsurge, Imperial Mandate with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Cassiopeia?

The best Seraphine runes against Cassiopeia use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Cassiopeia?

No, Seraphine struggles against Cassiopeia with only a 22.2% win rate. Cassiopeia has the advantage in this matchup. Seraphine players should focus on safe farming and avoiding extended trades to minimize Cassiopeia's lead.

How do I play Seraphine against Cassiopeia?

When playing Seraphine against Cassiopeia, play cautiously and avoid Cassiopeia's power spikes. Look for jungle assistance and team-dependent plays since Cassiopeia has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.