Karthusvs Zoe
Karthus vs Zoe is a decisive matchup in LoL patch 26.10. Zoe wins with a 66.7% win rate (+33.3%) over Karthus based on 6 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Zoe matchup.
Karthus Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Zoe(33.3%)Who Wins the Karthus vs Zoe Matchup?
Karthus vs Zoe Matchup Summary
The Karthus vs Zoe matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Zoe wins with a 66.7% win rate compared to Karthus's 33.3%, giving Zoe a 33.3 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Zoe leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zoe overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Karthus vs Zoe Laning Phase Breakdown
Karthus is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.
Best Karthus Build Against Zoe
Spellslinger's Shoes is the optimal boots choice against Zoe, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Zoe are Shadowflame, Malignance and Seraph's Embrace. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Zoe matchup.
Early Game vs Late Game
Karthus33.3%Zoe66.7%Karthus33.3%Zoe66.7%Zoe dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Karthus. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Zoe is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Karthus. Extended games heavily favor Zoe, whose kit and scaling make them a dominant force in team fights and objective control.
Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Karthus Runes Against Zoe
Domination
Sorcery
The Domination and Sorcery rune setup gives Karthus the best tools to compete against Zoe in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Karthus matchup data for League of Legends patch 26.10. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 37.18% | 78 | 1.4 | 1,153 | 13,138 | 38.9% | 35.7% | |
| 53.25% | 77 | 6.5 | 1,417 | 15,462 | 50.0% | 54.5% | |
| 45.59% | 68 | 6.4 | 1,360 | 14,512 | 50.0% | 42.9% | |
| 57.58% | 66 | 1.3 | 1,254 | 13,761 | 50.0% | 63.9% | |
| 58.46% | 65 | 1.5 | 1,193 | 15,012 | 50.0% | 61.2% | |
| 60.34% | 58 | 1.4 | 1,241 | 14,374 | 57.1% | 62.2% | |
| 47.37% | 57 | 1.4 | 1,170 | 13,600 | 59.1% | 40.0% | |
| 52.63% | 57 | 6.4 | 1,318 | 14,544 | 71.4% | 41.7% | |
| 48.21% | 56 | 1.4 | 1,232 | 13,681 | 46.4% | 50.0% | |
| 50.91% | 55 | 1.7 | 1,211 | 13,635 | 55.0% | 48.6% | |
| 42.31% | 52 | 1.3 | 1,153 | 13,355 | 55.6% | 35.3% | |
| 39.13% | 46 | 6.5 | 1,199 | 12,269 | 55.0% | 26.9% | |
| 55.81% | 43 | 6.2 | 1,246 | 13,335 | 46.7% | 60.7% | |
| 47.62% | 42 | 1.5 | 1,290 | 14,601 | 35.7% | 53.6% | |
| 42.86% | 42 | 6.8 | 1,291 | 15,345 | 46.1% | 41.4% | |
| 53.85% | 39 | 1.3 | 1,083 | 13,891 | 50.0% | 56.5% | |
| 44.74% | 38 | 1.6 | 1,071 | 12,678 | 42.9% | 47.1% | |
| 50.00% | 32 | 1.4 | 1,330 | 13,822 | 42.9% | 55.6% | |
| 51.61% | 31 | 1.5 | 1,192 | 14,807 | 58.3% | 47.4% | |
| 58.62% | 29 | 1.5 | 1,226 | 15,437 | 61.5% | 56.3% | |
| 55.17% | 29 | 1.4 | 1,127 | 12,931 | 45.5% | 61.1% | |
| 65.52% | 29 | 1.9 | 1,198 | 15,759 | 62.5% | 66.7% | |
| 55.17% | 29 | 6.5 | 1,358 | 14,398 | 50.0% | 57.9% | |
| 53.57% | 28 | 6.6 | 1,216 | 13,213 | 60.0% | 50.0% | |
| 64.29% | 28 | 1.4 | 1,223 | 14,324 | 84.6% | 46.7% | |
| 42.86% | 28 | 1.3 | 1,192 | 14,249 | 20.0% | 55.6% | |
| 55.56% | 27 | 1.3 | 1,086 | 12,615 | 46.7% | 66.7% | |
| 48.15% | 27 | 1.4 | 1,122 | 12,789 | 36.4% | 56.3% | |
| 55.56% | 27 | 6.4 | 1,337 | 13,964 | 54.5% | 56.3% | |
| 29.63% | 27 | 1.3 | 1,231 | 14,407 | 30.0% | 29.4% | |
| 66.67% | 24 | 1.7 | 1,192 | 14,438 | 77.8% | 60.0% | |
| 29.17% | 24 | 5.9 | 1,094 | 13,234 | 18.2% | 38.5% | |
| 56.52% | 23 | 2.1 | 1,145 | 14,995 | 50.0% | 57.9% | |
| 56.52% | 23 | 3.1 | 1,341 | 14,438 | 85.7% | 43.8% | |
| 52.17% | 23 | 1.6 | 1,267 | 14,735 | 55.6% | 50.0% | |
| 43.48% | 23 | 6.1 | 1,465 | 13,788 | 50.0% | 41.2% | |
| 39.13% | 23 | 5.6 | 1,294 | 15,378 | 40.0% | 38.9% | |
| 43.48% | 23 | 1.8 | 1,122 | 13,051 | 28.6% | 50.0% | |
| 31.82% | 22 | 1.9 | 1,066 | 11,545 | 22.2% | 38.5% | |
| 54.55% | 22 | 4.1 | 1,326 | 13,632 | 85.7% | 40.0% | |
| 38.10% | 21 | 1.4 | 1,336 | 14,666 | 71.4% | 21.4% | |
| 78.95% | 19 | 6.2 | 1,338 | 13,726 | 75.0% | 81.8% | |
| 52.63% | 19 | 6.0 | 1,252 | 14,200 | 75.0% | 36.4% | |
| 73.68% | 19 | 3.3 | 1,352 | 15,647 | 60.0% | 78.6% | |
| 42.11% | 19 | 1.3 | 1,158 | 14,055 | 30.0% | 55.6% | |
| 55.56% | 18 | 5.2 | 1,264 | 14,535 | 66.7% | 53.3% | |
| 55.56% | 18 | 3.7 | 1,150 | 13,787 | 75.0% | 40.0% | |
| 64.71% | 17 | 7.0 | 1,222 | 15,350 | 66.7% | 63.6% | |
| 47.06% | 17 | 2.4 | 1,022 | 13,118 | 50.0% | 44.4% | |
| 43.75% | 16 | 6.7 | 1,160 | 11,320 | 44.4% | 42.9% | |
| 62.50% | 16 | 6.1 | 1,331 | 14,065 | 20.0% | 81.8% | |
| 50.00% | 16 | 2.8 | 1,071 | 13,133 | 50.0% | 50.0% | |
| 46.67% | 15 | 6.5 | 1,247 | 14,311 | 66.7% | 33.3% | |
| 26.67% | 15 | 1.5 | 1,232 | 12,726 | 14.3% | 37.5% | |
| 46.67% | 15 | 3.9 | 882 | 10,390 | 60.0% | 40.0% | |
| 60.00% | 15 | 6.4 | 1,389 | 13,391 | 62.5% | 57.1% | |
| 60.00% | 15 | 1.4 | 957 | 13,336 | 57.1% | 62.5% | |
| 60.00% | 15 | 6.9 | 1,239 | 13,742 | 44.4% | 83.3% | |
| 78.57% | 14 | 2.2 | 1,432 | 14,546 | 66.7% | 87.5% | |
| 64.29% | 14 | 1.9 | 1,559 | 16,346 | 100.0% | 50.0% | |
| 71.43% | 14 | 1.2 | 1,262 | 14,227 | 50.0% | 80.0% | |
| 50.00% | 14 | 1.3 | 1,137 | 13,684 | 66.7% | 37.5% | |
| 38.46% | 13 | 6.1 | 1,208 | 14,228 | 75.0% | 22.2% | |
| 30.77% | 13 | 1.5 | 1,178 | 13,679 | 33.3% | 30.0% | |
| 53.85% | 13 | 6.1 | 1,265 | 13,447 | 80.0% | 37.5% | |
| 53.85% | 13 | 3.4 | 1,102 | 13,516 | 83.3% | 28.6% | |
| 33.33% | 12 | 6.4 | 1,059 | 10,641 | 0.0% | 50.0% | |
| 66.67% | 12 | 1.4 | 1,264 | 14,278 | 80.0% | 57.1% | |
| 27.27% | 11 | 2.2 | 1,086 | 13,892 | 66.7% | 12.5% | |
| 72.73% | 11 | 6.5 | 1,320 | 11,648 | 66.7% | 75.0% | |
| 50.00% | 10 | 7.0 | 1,444 | 14,945 | 25.0% | 66.7% | |
| 50.00% | 10 | 5.9 | 1,351 | 14,379 | 33.3% | 57.1% | |
| 30.00% | 10 | 6.1 | 1,481 | 14,056 | 25.0% | 33.3% | |
| 40.00% | 10 | 3.8 | 1,291 | 13,534 | 33.3% | 42.9% | |
| 40.00% | 10 | 6.1 | 1,078 | 11,609 | 42.9% | 33.3% | |
| 55.56% | 9 | 1.8 | 1,204 | 14,653 | 33.3% | 66.7% | |
| 66.67% | 9 | 6.8 | 1,184 | 14,870 | 33.3% | 83.3% | |
| 66.67% | 9 | 2.3 | 912 | 10,747 | 80.0% | 50.0% | |
| 66.67% | 9 | 1.2 | 1,226 | 13,299 | 75.0% | 60.0% | |
| 55.56% | 9 | 7.4 | 1,408 | 13,402 | 100.0% | 50.0% | |
| 66.67% | 9 | 6.9 | 1,195 | 9,975 | 60.0% | 75.0% | |
| 62.50% | 8 | 4.8 | 1,045 | 12,049 | 50.0% | 66.7% | |
| 37.50% | 8 | 4.3 | 1,528 | 13,284 | 25.0% | 50.0% | |
| 25.00% | 8 | 1.9 | 1,391 | 15,766 | 50.0% | 16.7% | |
| 12.50% | 8 | 1.7 | 1,016 | 13,371 | 0.0% | 25.0% | |
| 50.00% | 8 | 5.3 | 1,040 | 10,849 | 50.0% | 50.0% | |
| 57.14% | 7 | 5.6 | 1,291 | 16,133 | 100.0% | 40.0% | |
| 0.00% | 7 | 2.4 | 1,130 | 10,556 | 0.0% | 0.0% | |
| 42.86% | 7 | 6.1 | 1,266 | 11,443 | 50.0% | 33.3% | |
| 100.00% | 7 | 1.3 | 1,299 | 13,777 | 100.0% | 100.0% | |
| 28.57% | 7 | 2.4 | 1,093 | 10,568 | 20.0% | 50.0% | |
| 28.57% | 7 | 6.9 | 1,031 | 13,501 | 0.0% | 40.0% | |
| 71.43% | 7 | 6.8 | 1,219 | 13,781 | 66.7% | 75.0% | |
| 28.57% | 7 | 6.0 | 1,480 | 13,096 | 0.0% | 40.0% | |
| 71.43% | 7 | 1.7 | 1,022 | 12,652 | 75.0% | 66.7% | |
| 42.86% | 7 | 2.7 | 1,100 | 10,358 | 50.0% | 33.3% | |
| 85.71% | 7 | 6.8 | 1,463 | 14,208 | 75.0% | 100.0% | |
| 50.00% | 6 | 5.3 | 1,312 | 12,230 | 50.0% | 50.0% | |
| 33.33% | 6 | 4.8 | 1,338 | 11,064 | 33.3% | 33.3% | |
| 33.33% | 6 | 5.7 | 1,410 | 12,768 | 33.3% | 33.3% | |
| 50.00% | 6 | 6.5 | 1,028 | 7,278 | 50.0% | 50.0% | |
| 33.33% | 6 | 3.2 | 1,299 | 14,286 | 33.3% | 33.3% | |
| 50.00% | 6 | 6.3 | 1,240 | 13,906 | 100.0% | 0.0% | |
| 60.00% | 5 | 2.9 | 841 | 5,145 | 50.0% | 100.0% | |
| 40.00% | 5 | 2.6 | 1,341 | 12,432 | 0.0% | 66.7% | |
| 20.00% | 5 | 6.1 | 1,589 | 15,440 | 0.0% | 25.0% | |
| 40.00% | 5 | 6.6 | 1,259 | 12,355 | 66.7% | 0.0% | |
| 60.00% | 5 | 5.6 | 1,023 | 11,684 | 33.3% | 100.0% | |
| 20.00% | 5 | 6.7 | 1,493 | 17,739 | 0.0% | 20.0% | |
| 40.00% | 5 | 6.8 | 703 | 8,944 | 25.0% | 100.0% | |
| 60.00% | 5 | 6.7 | 1,329 | 14,380 | 0.0% | 75.0% | |
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Karthus vs Zoe - Frequently Asked Questions
How does Karthus do against Zoe in League of Legends?
Zoe wins the Karthus vs Zoe matchup with a 66.7% win rate compared to Karthus's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.10.
How does Karthus do against Zoe in the early game?
In the early game, Zoe has the advantage against Karthus with a 66.7% win rate versus 33.3%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Karthus do against Zoe in the late game?
In the late game, Zoe takes over the Karthus vs Zoe matchup with a 66.7% win rate compared to 33.3%. Zoe scales better into team fights and objective contests after 25 minutes.
Who wins the Karthus vs Zoe matchup?
Zoe wins the matchup against Karthus with a 66.7% win rate in League of Legends patch 26.10. The 33.3 percentage point advantage means Zoe is significantly favored in this lane matchup based on 6 games analyzed.
What is the best Karthus build against Zoe?
The best Karthus build against Zoe includes Shadowflame, Malignance, Seraph's Embrace with Spellslinger's Shoes. Check the matchup breakdown above for the full item path and build order.
What are the best Karthus runes against Zoe?
The best Karthus runes against Zoe use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Zoe matchup. See the full rune breakdown in the matchup comparison above.
Does Karthus counter Zoe?
No, Karthus struggles against Zoe with only a 33.3% win rate. Zoe has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Zoe's lead.
How do I play Karthus against Zoe?
When playing Karthus against Zoe, play cautiously and avoid Zoe's power spikes. Look for jungle assistance and team-dependent plays since Zoe has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.