Lissandra - League of Legends Champion
Win Rate
52.3%
Pick Rate
1.9%

Lissandravs Senna

SMage
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Lissandra vs Senna is a very close matchup in LoL patch 26.10. Lissandra wins with a 50.0% win rate (+0.0%) over Senna based on 8 games. Lissandra wins the early laning phase while Senna scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Senna matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Senna - 50.0% win rateSenna(50.0%)
Lissandra - 50.0% win rate in this matchup
Lissandra
50.0% WR
VS
Senna vs Lissandra matchup - 50.0% win rate
Senna
50.0% WR

Who Wins the Lissandra vs Senna Matchup?

Lissandra wins the Lissandra vs Senna matchup
Winner
Lissandra
Matches: 8
50.0%
Win Rate
50.0%
3.7
CS / min
3.6
808
DMG / min
885
12,858
Gold / game
14,314
173
Heal / min
475
513
DMG Mitigated / min
490
1.8
CC / min
1.4
66.7%
Early Game WR
33.3%
40.0%
Late Game WR
60.0%

Lissandra vs Senna Matchup Summary

The Lissandra vs Senna matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Lissandra wins with a 50.0% win rate compared to Senna's 50.0%, giving Lissandra a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Senna leads by 279 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a statistical edge, but the margin is close enough that respecting Senna's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Senna Laning Phase Breakdown

Senna wins the laning phase against Lissandra in League of Legends

Senna is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Senna holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
3.7Lissandra
3.6Senna
Lissandra and Senna farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
808Lissandra
885Senna
Senna deals 77 more champion damage per minute than Lissandra. While noticeable in extended trades, this gap can be offset by Lissandra choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
12,858Lissandra
14,314Senna
Senna generates a commanding 1,456 more gold per game than Lissandra. This substantial economic advantage means Senna consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.8Lissandra
1.4Senna
Lissandra provides 0.5 seconds more crowd control per minute than Senna, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
686Lissandra
965Senna
Senna vastly out-sustains Lissandra, healing and mitigating 279 more damage per minute. This massive durability gap means Senna can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Senna

Sorcerer's Shoes is the optimal boots choice against Senna, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Senna are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Senna. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Senna matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Lissandra early game win rateLissandra66.7%
Senna early game win rateSenna33.3%
Late Game
Senna
60.0%
+20.0% advantage
Lissandra late game win rateLissandra40.0%
Senna late game win rateSenna60.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Senna. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Senna is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Lissandra. Extended games heavily favor Senna, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Senna reaches their scaling breakpoints. If Senna survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Lissandra Runes Against Senna

Resolve rune tree - Lissandra primary runes vs SennaResolve
Aftershock - best Lissandra rune vs SennaFont of Life - best Lissandra rune vs SennaBone Plating - best Lissandra rune vs SennaUnflinching - best Lissandra rune vs Senna
Domination rune tree - Lissandra secondary runes vs SennaDomination
Cheap Shot - best Lissandra rune vs SennaUltimate Hunter - best Lissandra rune vs Senna
100.0% WR

The Resolve primary with Domination secondary combination helps Lissandra maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Senna.


Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.35%1496.677111,28049.3%54.9%
54.35%1386.883812,17660.4%50.6%
55.56%1356.779712,02060.8%52.4%
58.82%1196.585711,81445.3%69.7%
53.85%1046.691412,01655.6%52.9%
50.98%1026.672711,35753.5%49.1%
50.00%806.886711,96240.0%56.0%
47.37%765.974811,29345.5%48.8%
45.21%736.568110,57627.3%60.0%
52.17%696.996112,15155.2%50.0%
53.13%646.588712,25569.2%42.1%
42.37%596.378711,75545.0%41.0%
41.38%586.680412,36452.2%34.3%
43.14%516.991310,43742.3%44.0%
42.86%427.390910,24141.7%44.4%
47.62%426.876010,09547.8%47.4%
43.59%396.492411,96047.1%40.9%
47.37%386.773912,00953.3%43.5%
60.53%386.682310,50361.9%58.8%
54.29%356.582911,10157.9%50.0%
55.88%346.288711,52147.1%64.7%
50.00%346.793312,04433.3%59.1%
43.33%306.375411,37862.5%36.4%
43.33%306.181910,81153.9%35.3%
50.00%306.783811,58266.7%38.9%
53.33%306.476812,25175.0%45.5%
65.52%297.089411,64469.2%62.5%
57.14%286.683111,94141.7%68.8%
50.00%286.680410,04369.2%33.3%
48.15%276.790212,52950.0%47.4%
40.74%277.088912,17457.1%35.0%
46.15%266.980410,29062.5%20.0%
30.77%266.793811,90144.4%23.5%
46.15%266.978211,53466.7%35.3%
29.17%245.895512,91442.9%23.5%
63.64%226.780410,92969.2%55.6%
61.90%216.279511,32762.5%61.5%
52.38%216.884811,51866.7%41.7%
45.00%207.185310,18254.5%33.3%
57.89%196.189310,29954.5%62.5%
33.33%186.465611,45037.5%30.0%
55.56%185.679210,17166.7%44.4%
17.65%175.868812,21714.3%20.0%
43.75%163.559310,75350.0%41.7%
68.75%166.588012,43080.0%63.6%
64.29%147.090011,20040.0%77.8%
42.86%147.176211,12255.6%20.0%
57.14%146.887914,155100.0%45.5%
46.15%136.683211,21450.0%40.0%
41.67%126.385814,250100.0%36.4%
75.00%125.977512,474100.0%66.7%
36.36%116.788512,71725.0%42.9%
72.73%116.678011,31550.0%85.7%
81.82%117.892313,197100.0%66.7%
70.00%106.681311,36880.0%60.0%
33.33%97.577010,76266.7%16.7%
33.33%96.773911,320100.0%14.3%
44.44%96.975912,01160.0%25.0%
50.00%83.780812,85866.7%40.0%
37.50%87.391710,19520.0%66.7%
62.50%87.589112,23766.7%60.0%
50.00%87.31,05311,45750.0%50.0%
25.00%81.54948,3330.0%40.0%
50.00%82.75139,630100.0%33.3%
50.00%87.01,06011,42833.3%60.0%
62.50%86.091112,81766.7%60.0%
25.00%87.080111,32920.0%33.3%
50.00%86.11,00311,85340.0%66.7%
12.50%85.575810,4670.0%14.3%
57.14%72.462312,2880.0%57.1%
42.86%71.85527,24760.0%0.0%
28.57%76.783812,06833.3%25.0%
57.14%76.57077,45375.0%33.3%
28.57%77.01,20012,84850.0%20.0%
71.43%77.094211,67033.3%100.0%
50.00%67.596513,326100.0%25.0%
83.33%67.61,02412,158100.0%66.7%
33.33%65.176510,856100.0%20.0%
33.33%66.278310,96850.0%25.0%
66.67%64.367711,77250.0%75.0%
83.33%66.51,01112,025100.0%75.0%
60.00%56.28127,81460.0%0.0%
80.00%56.994810,95466.7%100.0%
0.00%56.675011,4390.0%0.0%
40.00%56.880213,193100.0%25.0%
20.00%56.692910,16050.0%0.0%
40.00%56.992711,982100.0%25.0%

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Lissandra vs Senna - Frequently Asked Questions

How does Lissandra do against Senna in League of Legends?

Lissandra wins the Lissandra vs Senna matchup with a 50.0% win rate compared to Senna's 50.0%, a 0.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.

How does Lissandra do against Senna in the early game?

In the early game, Lissandra has the advantage against Senna with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Senna in the late game?

In the late game, Senna takes over the Lissandra vs Senna matchup with a 60.0% win rate compared to 40.0%. Senna scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Senna matchup?

Lissandra wins the matchup against Senna with a 50.0% win rate in League of Legends patch 26.10. The 0.0 percentage point advantage means Lissandra is slightly favored in this lane matchup based on 8 games analyzed.

What is the best Lissandra build against Senna?

The best Lissandra build against Senna includes Shadowflame, Zhonya's Hourglass, Malignance with Sorcerer's Shoes. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Senna?

The best Lissandra runes against Senna use the Resolve primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Senna matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Senna?

Yes, Lissandra has a favorable matchup against Senna with a 50.0% win rate. Lissandra slightly edges out Senna in lane based on current patch 26.10 data.

How do I play Lissandra against Senna?

When playing Lissandra against Senna, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.