
Lissandravs Senna
Lissandra vs Senna is a very close matchup in LoL patch 26.10. Lissandra wins with a 50.0% win rate (+0.0%) over Senna based on 8 games. Lissandra wins the early laning phase while Senna scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Senna matchup.
Lissandra Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Lissandra vs Senna Matchup?

Lissandra vs Senna Matchup Summary
The Lissandra vs Senna matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Lissandra wins with a 50.0% win rate compared to Senna's 50.0%, giving Lissandra a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Senna leads by 279 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a statistical edge, but the margin is close enough that respecting Senna's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Lissandra vs Senna Laning Phase Breakdown
Senna is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Senna holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.
Best Lissandra Build Against Senna
Sorcerer's Shoes is the optimal boots choice against Senna, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Senna are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Senna. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Senna matchup.
Early Game vs Late Game
Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Senna. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Senna is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Lissandra. Extended games heavily favor Senna, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Senna reaches their scaling breakpoints. If Senna survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Lissandra Runes Against Senna
The Resolve primary with Domination secondary combination helps Lissandra maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Senna.
Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 52.35% | 149 | 6.6 | 771 | 11,280 | 49.3% | 54.9% | |
| 54.35% | 138 | 6.8 | 838 | 12,176 | 60.4% | 50.6% | |
| 55.56% | 135 | 6.7 | 797 | 12,020 | 60.8% | 52.4% | |
| 58.82% | 119 | 6.5 | 857 | 11,814 | 45.3% | 69.7% | |
| 53.85% | 104 | 6.6 | 914 | 12,016 | 55.6% | 52.9% | |
| 50.98% | 102 | 6.6 | 727 | 11,357 | 53.5% | 49.1% | |
| 50.00% | 80 | 6.8 | 867 | 11,962 | 40.0% | 56.0% | |
| 47.37% | 76 | 5.9 | 748 | 11,293 | 45.5% | 48.8% | |
| 45.21% | 73 | 6.5 | 681 | 10,576 | 27.3% | 60.0% | |
| 52.17% | 69 | 6.9 | 961 | 12,151 | 55.2% | 50.0% | |
| 53.13% | 64 | 6.5 | 887 | 12,255 | 69.2% | 42.1% | |
| 42.37% | 59 | 6.3 | 787 | 11,755 | 45.0% | 41.0% | |
| 41.38% | 58 | 6.6 | 804 | 12,364 | 52.2% | 34.3% | |
| 43.14% | 51 | 6.9 | 913 | 10,437 | 42.3% | 44.0% | |
| 42.86% | 42 | 7.3 | 909 | 10,241 | 41.7% | 44.4% | |
| 47.62% | 42 | 6.8 | 760 | 10,095 | 47.8% | 47.4% | |
| 43.59% | 39 | 6.4 | 924 | 11,960 | 47.1% | 40.9% | |
| 47.37% | 38 | 6.7 | 739 | 12,009 | 53.3% | 43.5% | |
| 60.53% | 38 | 6.6 | 823 | 10,503 | 61.9% | 58.8% | |
| 54.29% | 35 | 6.5 | 829 | 11,101 | 57.9% | 50.0% | |
| 55.88% | 34 | 6.2 | 887 | 11,521 | 47.1% | 64.7% | |
| 50.00% | 34 | 6.7 | 933 | 12,044 | 33.3% | 59.1% | |
| 43.33% | 30 | 6.3 | 754 | 11,378 | 62.5% | 36.4% | |
| 43.33% | 30 | 6.1 | 819 | 10,811 | 53.9% | 35.3% | |
| 50.00% | 30 | 6.7 | 838 | 11,582 | 66.7% | 38.9% | |
| 53.33% | 30 | 6.4 | 768 | 12,251 | 75.0% | 45.5% | |
| 65.52% | 29 | 7.0 | 894 | 11,644 | 69.2% | 62.5% | |
| 57.14% | 28 | 6.6 | 831 | 11,941 | 41.7% | 68.8% | |
| 50.00% | 28 | 6.6 | 804 | 10,043 | 69.2% | 33.3% | |
| 48.15% | 27 | 6.7 | 902 | 12,529 | 50.0% | 47.4% | |
| 40.74% | 27 | 7.0 | 889 | 12,174 | 57.1% | 35.0% | |
| 46.15% | 26 | 6.9 | 804 | 10,290 | 62.5% | 20.0% | |
| 30.77% | 26 | 6.7 | 938 | 11,901 | 44.4% | 23.5% | |
| 46.15% | 26 | 6.9 | 782 | 11,534 | 66.7% | 35.3% | |
| 29.17% | 24 | 5.8 | 955 | 12,914 | 42.9% | 23.5% | |
| 63.64% | 22 | 6.7 | 804 | 10,929 | 69.2% | 55.6% | |
| 61.90% | 21 | 6.2 | 795 | 11,327 | 62.5% | 61.5% | |
| 52.38% | 21 | 6.8 | 848 | 11,518 | 66.7% | 41.7% | |
| 45.00% | 20 | 7.1 | 853 | 10,182 | 54.5% | 33.3% | |
| 57.89% | 19 | 6.1 | 893 | 10,299 | 54.5% | 62.5% | |
| 33.33% | 18 | 6.4 | 656 | 11,450 | 37.5% | 30.0% | |
| 55.56% | 18 | 5.6 | 792 | 10,171 | 66.7% | 44.4% | |
| 17.65% | 17 | 5.8 | 688 | 12,217 | 14.3% | 20.0% | |
| 43.75% | 16 | 3.5 | 593 | 10,753 | 50.0% | 41.7% | |
| 68.75% | 16 | 6.5 | 880 | 12,430 | 80.0% | 63.6% | |
| 64.29% | 14 | 7.0 | 900 | 11,200 | 40.0% | 77.8% | |
| 42.86% | 14 | 7.1 | 762 | 11,122 | 55.6% | 20.0% | |
| 57.14% | 14 | 6.8 | 879 | 14,155 | 100.0% | 45.5% | |
| 46.15% | 13 | 6.6 | 832 | 11,214 | 50.0% | 40.0% | |
| 41.67% | 12 | 6.3 | 858 | 14,250 | 100.0% | 36.4% | |
| 75.00% | 12 | 5.9 | 775 | 12,474 | 100.0% | 66.7% | |
| 36.36% | 11 | 6.7 | 885 | 12,717 | 25.0% | 42.9% | |
| 72.73% | 11 | 6.6 | 780 | 11,315 | 50.0% | 85.7% | |
| 81.82% | 11 | 7.8 | 923 | 13,197 | 100.0% | 66.7% | |
| 70.00% | 10 | 6.6 | 813 | 11,368 | 80.0% | 60.0% | |
| 33.33% | 9 | 7.5 | 770 | 10,762 | 66.7% | 16.7% | |
| 33.33% | 9 | 6.7 | 739 | 11,320 | 100.0% | 14.3% | |
| 44.44% | 9 | 6.9 | 759 | 12,011 | 60.0% | 25.0% | |
| 50.00% | 8 | 3.7 | 808 | 12,858 | 66.7% | 40.0% | |
| 37.50% | 8 | 7.3 | 917 | 10,195 | 20.0% | 66.7% | |
| 62.50% | 8 | 7.5 | 891 | 12,237 | 66.7% | 60.0% | |
| 50.00% | 8 | 7.3 | 1,053 | 11,457 | 50.0% | 50.0% | |
| 25.00% | 8 | 1.5 | 494 | 8,333 | 0.0% | 40.0% | |
| 50.00% | 8 | 2.7 | 513 | 9,630 | 100.0% | 33.3% | |
| 50.00% | 8 | 7.0 | 1,060 | 11,428 | 33.3% | 60.0% | |
| 62.50% | 8 | 6.0 | 911 | 12,817 | 66.7% | 60.0% | |
| 25.00% | 8 | 7.0 | 801 | 11,329 | 20.0% | 33.3% | |
| 50.00% | 8 | 6.1 | 1,003 | 11,853 | 40.0% | 66.7% | |
| 12.50% | 8 | 5.5 | 758 | 10,467 | 0.0% | 14.3% | |
| 57.14% | 7 | 2.4 | 623 | 12,288 | 0.0% | 57.1% | |
| 42.86% | 7 | 1.8 | 552 | 7,247 | 60.0% | 0.0% | |
| 28.57% | 7 | 6.7 | 838 | 12,068 | 33.3% | 25.0% | |
| 57.14% | 7 | 6.5 | 707 | 7,453 | 75.0% | 33.3% | |
| 28.57% | 7 | 7.0 | 1,200 | 12,848 | 50.0% | 20.0% | |
| 71.43% | 7 | 7.0 | 942 | 11,670 | 33.3% | 100.0% | |
| 50.00% | 6 | 7.5 | 965 | 13,326 | 100.0% | 25.0% | |
| 83.33% | 6 | 7.6 | 1,024 | 12,158 | 100.0% | 66.7% | |
| 33.33% | 6 | 5.1 | 765 | 10,856 | 100.0% | 20.0% | |
| 33.33% | 6 | 6.2 | 783 | 10,968 | 50.0% | 25.0% | |
| 66.67% | 6 | 4.3 | 677 | 11,772 | 50.0% | 75.0% | |
| 83.33% | 6 | 6.5 | 1,011 | 12,025 | 100.0% | 75.0% | |
| 60.00% | 5 | 6.2 | 812 | 7,814 | 60.0% | 0.0% | |
| 80.00% | 5 | 6.9 | 948 | 10,954 | 66.7% | 100.0% | |
| 0.00% | 5 | 6.6 | 750 | 11,439 | 0.0% | 0.0% | |
| 40.00% | 5 | 6.8 | 802 | 13,193 | 100.0% | 25.0% | |
| 20.00% | 5 | 6.6 | 929 | 10,160 | 50.0% | 0.0% | |
| 40.00% | 5 | 6.9 | 927 | 11,982 | 100.0% | 25.0% | |
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Lissandra vs Senna - Frequently Asked Questions
How does Lissandra do against Senna in League of Legends?
Lissandra wins the Lissandra vs Senna matchup with a 50.0% win rate compared to Senna's 50.0%, a 0.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.10.
How does Lissandra do against Senna in the early game?
In the early game, Lissandra has the advantage against Senna with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Lissandra do against Senna in the late game?
In the late game, Senna takes over the Lissandra vs Senna matchup with a 60.0% win rate compared to 40.0%. Senna scales better into team fights and objective contests after 25 minutes.
Who wins the Lissandra vs Senna matchup?
Lissandra wins the matchup against Senna with a 50.0% win rate in League of Legends patch 26.10. The 0.0 percentage point advantage means Lissandra is slightly favored in this lane matchup based on 8 games analyzed.
What is the best Lissandra build against Senna?
The best Lissandra build against Senna includes Shadowflame, Zhonya's Hourglass, Malignance with Sorcerer's Shoes. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Lissandra runes against Senna?
The best Lissandra runes against Senna use the Resolve primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Senna matchup. See the full rune breakdown in the matchup comparison above.
Does Lissandra counter Senna?
Yes, Lissandra has a favorable matchup against Senna with a 50.0% win rate. Lissandra slightly edges out Senna in lane based on current patch 26.10 data.
How do I play Lissandra against Senna?
When playing Lissandra against Senna, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.
