Lissandra - League of Legends Champion
Win Rate
51.8%
Pick Rate
1.9%

Lissandravs Senna

SMage
Patch26.13
Matches265,623
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 8, 2026
MethodologyData Methodology

Lissandra vs Senna is a decisive matchup in LoL patch 26.13. Senna wins with a 80.0% win rate (+60.0%) over Lissandra based on 5 games. Senna holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Senna matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 20.0% win rate in this matchup
Lissandra
20.0% WR
VS
Senna vs Lissandra matchup - 80.0% win rate
Senna
80.0% WR

Who Wins the Lissandra vs Senna Matchup?

Senna wins the Lissandra vs Senna matchup
Winner
Senna
Matches: 5
20.0%
Win Rate
80.0%
4.8
CS / min
3.7
933
DMG / min
1,003
11,855
Gold / game
12,038
195
Heal / min
472
399
DMG Mitigated / min
369
1.9
CC / min
1.4
0.0%
Early Game WR
100.0%
33.3%
Late Game WR
66.7%

Lissandra vs Senna Matchup Summary

The Lissandra vs Senna matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Senna wins with a 80.0% win rate compared to Lissandra's 20.0%, giving Senna a 60.0 percentage point advantage. Senna dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Senna leads by 248 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Senna has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Senna overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Senna Laning Phase Breakdown

Senna wins the laning phase against Lissandra in League of Legends

Senna is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Senna holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.8Lissandra
3.7Senna
Lissandra significantly out-farms Senna by 1.1 CS per minute, accumulating an estimated 16 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Senna players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
933Lissandra
1,003Senna
Senna deals 70 more champion damage per minute than Lissandra. While noticeable in extended trades, this gap can be offset by Lissandra choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
11,855Lissandra
12,038Senna
Lissandra and Senna generate nearly equal gold per game, with just a 184 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.9Lissandra
1.4Senna
Lissandra provides 0.5 seconds more crowd control per minute than Senna, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
594Lissandra
842Senna
Senna vastly out-sustains Lissandra, healing and mitigating 248 more damage per minute. This massive durability gap means Senna can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Senna
100.0%
+100.0% advantage
Lissandra early game win rateLissandra0.0%
Senna early game win rateSenna100.0%
Late Game
Senna
66.7%
+33.3% advantage
Lissandra late game win rateLissandra33.3%
Senna late game win rateSenna66.7%

Senna dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Lissandra. This lopsided early game means Senna can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Senna is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Lissandra. Extended games heavily favor Senna, whose kit and scaling make them a dominant force in team fights and objective control.

Senna holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Senna

Sorcery rune tree - Lissandra primary runes vs SennaSorcery
Arcane Comet - best Lissandra rune vs SennaManaflow Band - best Lissandra rune vs SennaTranscendence - best Lissandra rune vs SennaScorch - best Lissandra rune vs Senna
Domination rune tree - Lissandra secondary runes vs SennaDomination
Cheap Shot - best Lissandra rune vs SennaUltimate Hunter - best Lissandra rune vs Senna
100.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Senna in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.13. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.13
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
62.50%1046.287011,65362.8%62.3%
52.27%446.691712,49561.1%46.1%
58.14%437.082910,86958.6%57.1%
65.79%386.789712,41276.9%60.0%
43.33%306.975712,69758.3%33.3%
41.38%296.767811,09846.1%37.5%
37.04%276.594612,36850.0%26.7%
60.00%256.486410,78360.0%60.0%
59.09%226.282611,82060.0%58.3%
72.73%226.791113,21566.7%76.9%
60.00%206.892911,05960.0%60.0%
36.84%195.66708,44541.7%28.6%
58.82%176.372011,82066.7%54.5%
43.75%166.366111,04337.5%50.0%
68.75%165.875610,74862.5%75.0%
37.50%166.989311,18642.9%33.3%
43.75%165.875610,75314.3%66.7%
33.33%156.466010,85128.6%37.5%
66.67%157.186211,10287.5%42.9%
53.33%157.089611,55537.5%71.4%
61.54%135.478012,570100.0%50.0%
66.67%126.091911,53550.0%83.3%
33.33%126.370010,67528.6%40.0%
40.00%107.087111,36840.0%40.0%
60.00%105.775212,2450.0%66.7%
60.00%106.987410,44650.0%75.0%
0.00%106.584210,4170.0%0.0%
55.56%96.681910,51740.0%75.0%
77.78%96.192011,05260.0%100.0%
37.50%87.385812,88350.0%33.3%
37.50%85.164810,4930.0%75.0%
42.86%74.863811,84733.3%50.0%
85.71%76.191115,773100.0%83.3%
42.86%75.889612,99050.0%40.0%
42.86%77.493311,80066.7%25.0%
42.86%77.297313,29450.0%40.0%
33.33%62.36469,85933.3%33.3%
16.67%67.459211,22733.3%0.0%
20.00%52.66667,50025.0%0.0%
20.00%54.893311,8550.0%33.3%
60.00%57.181411,48166.7%50.0%
40.00%57.081211,2710.0%100.0%
60.00%57.372411,814100.0%33.3%
80.00%57.178312,25466.7%100.0%
20.00%57.01,07212,6230.0%33.3%
60.00%55.971211,78866.7%50.0%
20.00%57.086212,46533.3%0.0%

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Lissandra vs Senna - Frequently Asked Questions

How does Lissandra do against Senna in League of Legends?

Senna wins the Lissandra vs Senna matchup with a 80.0% win rate compared to Lissandra's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.13.

How does Lissandra do against Senna in the early game?

In the early game, Senna has the advantage against Lissandra with a 100.0% win rate versus 0.0%. Senna players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Senna in the late game?

In the late game, Senna takes over the Lissandra vs Senna matchup with a 66.7% win rate compared to 33.3%. Senna scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Senna matchup?

Senna wins the matchup against Lissandra with a 80.0% win rate in League of Legends patch 26.13. The 60.0 percentage point advantage means Senna is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Lissandra build against Senna?

The best Lissandra build against Senna includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Senna?

The best Lissandra runes against Senna use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Senna matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Senna?

No, Lissandra struggles against Senna with only a 20.0% win rate. Senna has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Senna's lead.

How do I play Lissandra against Senna?

When playing Lissandra against Senna, play cautiously and avoid Senna's power spikes. Look for jungle assistance and team-dependent plays since Senna has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.