Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

Seraphinevs Milio

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Seraphine vs Milio is a decisive matchup in LoL patch 26.7. Milio wins with a 55.6% win rate (+11.1%) over Seraphine based on 126 games. Milio holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Milio matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Milio - 44.4% win rateMilio(44.4%)
Seraphine - 44.4% win rate in this matchup
Seraphine
44.4% WR
VS
Milio vs Seraphine matchup - 55.6% win rate
Milio
55.6% WR

Who Wins the Seraphine vs Milio Matchup?

Milio wins the Seraphine vs Milio matchup
Winner
Milio
Matches: 126
44.4%
Win Rate
55.6%
1.3
CS / min
0.9
407
DMG / min
188
8,509
Gold / game
8,154
320
Heal / min
452
338
DMG Mitigated / min
323
1.1
CC / min
0.7
42.9%
Early Game WR
57.1%
46.0%
Late Game WR
54.0%

Seraphine vs Milio Matchup Summary

The Seraphine vs Milio matchup is a decisive matchup in League of Legends ranked play. Based on 126 recent matches analyzed, Milio wins with a 55.6% win rate compared to Seraphine's 44.4%, giving Milio a 11.1 percentage point advantage. Milio dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Seraphine players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Seraphine leads by 219 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Milio has a strong advantage in this matchup. Seraphine players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Milio overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Milio Laning Phase Breakdown

Seraphine wins the laning phase against Milio in League of Legends

Seraphine is favored during the laning phase against Milio, winning 4 out of 5 key stat categories. Seraphine holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.3Seraphine
0.9Milio
Seraphine edges out Milio by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Seraphine.
Damage
407Seraphine
188Milio
Seraphine heavily out-damages Milio by 219 DMG/min, dominating both short trades and all-in fights. Milio should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Seraphine's sustained damage advantage take over.
Economy
8,509Seraphine
8,154Milio
Seraphine earns 355 more gold per game than Milio, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Seraphine slightly faster item completions.
Utility
1.1Seraphine
0.7Milio
Seraphine provides 0.5 seconds more crowd control per minute than Milio, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Seraphine coordinate with their jungler and control the pace of skirmishes.
Sustain
658Seraphine
776Milio
Milio heals and mitigates 118 more damage per minute than Seraphine, providing moderate extra durability. This sustain edge allows Milio to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Seraphine.

Best Seraphine Build Against Milio

Ionian Boots of Lucidity is the optimal boots choice against Milio, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Milio are Echoes of Helia, Moonstone Renewer and Diadem of Songs. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 80.0% win rate across 10 games — well above average and making it the top item path against Milio. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Milio matchup.

Early Game vs Late Game

Early Game
Milio
57.1%
+14.3% advantage
Seraphine early game win rateSeraphine42.9%
Milio early game win rateMilio57.1%
Late Game
Milio
54.0%
+7.9% advantage
Seraphine late game win rateSeraphine46.0%
Milio late game win rateMilio54.0%

Milio dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Seraphine. This lopsided early game means Milio can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Milio is far superior in the late game (25+ minutes), boasting a 54.0% win rate — 7.9 points above Seraphine. Extended games heavily favor Milio, whose kit and scaling make them a dominant force in team fights and objective control.

Milio holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Seraphine players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Milio

Sorcery rune tree - Seraphine primary runes vs MilioSorcery
Summon Aery - best Seraphine rune vs MilioManaflow Band - best Seraphine rune vs MilioTranscendence - best Seraphine rune vs MilioScorch - best Seraphine rune vs Milio
Inspiration rune tree - Seraphine secondary runes vs MilioInspiration
Biscuit Delivery - best Seraphine rune vs MilioCosmic Insight - best Seraphine rune vs Milio
52.9% WR

The Sorcery and Inspiration rune setup gives Seraphine the best tools to compete against Milio in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Seraphine matchup data for League of Legends patch 26.7. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
54.18%2991.64439,72745.0%59.6%
44.49%2631.34388,73041.4%48.0%
53.94%2411.34619,24352.6%55.2%
53.01%1831.44589,30748.8%56.4%
53.59%1811.44469,09849.4%57.5%
53.66%1641.44779,15159.3%48.2%
51.57%1591.54879,18454.3%49.4%
56.96%1581.44609,12365.1%51.6%
51.45%1381.44108,92450.8%52.1%
57.58%1321.44559,01657.4%57.8%
44.44%1261.34078,50942.9%46.0%
48.72%1171.655210,13343.2%51.3%
55.17%1161.54939,75339.1%65.7%
48.28%1161.754110,06752.2%45.7%
54.29%1051.34268,52558.2%50.0%
47.57%1031.54449,60136.6%54.8%
53.92%1021.44648,93753.9%54.0%
50.50%1011.43578,58654.9%46.0%
65.31%982.04699,74265.0%65.5%
51.11%901.45449,00546.1%54.9%
60.67%891.45258,87651.2%69.6%
48.05%771.64329,06447.1%48.8%
48.48%661.64499,83052.0%46.3%
56.06%661.446210,05756.0%56.1%
59.09%661.34709,19553.3%63.9%
51.52%661.45339,38642.9%57.9%
50.00%561.34318,78350.0%50.0%
50.91%555.059410,15445.7%60.0%
61.11%541.45039,73561.1%61.1%
45.10%511.45549,19748.0%42.3%
56.00%501.64589,66571.4%44.8%
68.09%471.34338,79683.3%52.2%
41.30%461.44408,44340.7%42.1%
55.26%386.575312,73061.1%50.0%
41.67%361.55229,34566.7%23.8%
45.71%351.45389,51041.2%50.0%
51.43%356.577612,68062.5%42.1%
41.18%341.95239,70342.9%40.0%
62.50%324.466312,14861.5%63.2%
61.54%261.45069,89770.0%56.3%
57.69%265.866912,09666.7%50.0%
72.00%253.654911,21477.8%68.8%
47.83%231.34387,54662.5%14.3%
39.13%231.34279,80042.9%37.5%
45.45%225.768813,31257.1%40.0%
42.86%212.04569,77930.0%54.5%
60.00%206.873212,63062.5%58.3%
68.42%192.25288,37271.4%60.0%
52.63%194.566310,72362.5%45.5%
77.78%185.262111,90780.0%75.0%
50.00%182.23929,53214.3%72.7%
17.65%171.95419,5550.0%30.0%
68.75%166.175711,132100.0%44.4%
56.25%165.061711,17950.0%58.3%
37.50%161.44408,74328.6%44.4%
40.00%155.879112,89180.0%20.0%
53.33%152.65158,83558.3%33.3%
60.00%156.969012,35375.0%42.9%
57.14%141.65038,97662.5%50.0%
50.00%126.066912,17266.7%33.3%
58.33%121.95109,80057.1%60.0%
41.67%124.362911,9680.0%50.0%
50.00%125.572511,57837.5%75.0%
45.45%111.83348,40757.1%25.0%
45.45%111.448611,0260.0%50.0%
20.00%101.94449,6570.0%40.0%
30.00%106.083411,91850.0%16.7%
66.67%95.04869,88271.4%50.0%
66.67%96.791812,31350.0%100.0%
44.44%91.652310,69633.3%50.0%
66.67%95.06849,58460.0%75.0%
55.56%95.878611,74075.0%40.0%
62.50%86.375213,234100.0%50.0%
62.50%84.164710,851100.0%0.0%
62.50%86.072611,59850.0%75.0%
50.00%81.63948,88825.0%75.0%
50.00%82.659011,57450.0%50.0%
37.50%84.34689,60866.7%20.0%
50.00%86.075212,12750.0%50.0%
75.00%81.84619,71750.0%100.0%
50.00%84.75939,70720.0%100.0%
28.57%71.54699,3480.0%50.0%
57.14%72.24578,64566.7%50.0%
85.71%71.55068,91275.0%100.0%
42.86%71.44499,4630.0%60.0%
50.00%63.866510,38850.0%50.0%
50.00%61.253910,07150.0%50.0%
50.00%62.45769,27866.7%33.3%
50.00%65.060611,31766.7%33.3%
40.00%56.077711,01533.3%50.0%
20.00%55.151210,8920.0%25.0%
60.00%55.872310,033100.0%50.0%
20.00%51.43949,2580.0%33.3%
80.00%54.677910,15775.0%100.0%
40.00%52.76589,47233.3%50.0%

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Seraphine vs Milio - Frequently Asked Questions

How does Seraphine do against Milio in League of Legends?

Milio wins the Seraphine vs Milio matchup with a 55.6% win rate compared to Seraphine's 44.4%, a 11.1 percentage point difference. This data is based on 126 recent ranked games in patch 26.7.

How does Seraphine do against Milio in the early game?

In the early game, Milio has the advantage against Seraphine with a 57.1% win rate versus 42.9%. Milio players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Milio in the late game?

In the late game, Milio takes over the Seraphine vs Milio matchup with a 54.0% win rate compared to 46.0%. Milio scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Milio matchup?

Milio wins the matchup against Seraphine with a 55.6% win rate in League of Legends patch 26.7. The 11.1 percentage point advantage means Milio is significantly favored in this lane matchup based on 126 games analyzed.

What is the best Seraphine build against Milio?

The best Seraphine build against Milio includes Echoes of Helia, Moonstone Renewer, Diadem of Songs with Ionian Boots of Lucidity. This build achieves a 80.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Milio?

The best Seraphine runes against Milio use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 52.9% win rate in the Seraphine vs Milio matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Milio?

No, Seraphine struggles against Milio with only a 44.4% win rate. Milio has the advantage in this matchup. Seraphine players should focus on safe farming and avoiding extended trades to minimize Milio's lead.

How do I play Seraphine against Milio?

When playing Seraphine against Milio, play cautiously and avoid Milio's power spikes. Look for jungle assistance and team-dependent plays since Milio has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.