Seraphine - League of Legends Champion
Win Rate
51.3%
Pick Rate
6.2%
Ban Rate
18.3%

Seraphinevs Vayne

Seraphine A TierSupportMage
Patch26.19
Games5,604
LaneAll Lanes
TierAll Tiers
Last UpdatedOct 1, 2026 UTC
MethodologyData Methodology

Seraphine vs Vayne is a very close matchup in LoL patch 26.19. Seraphine wins with a 50.0% win rate (+0.0%) over Vayne based on 8 games. Vayne wins the early laning phase while Seraphine scales better into the late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Vayne matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine
Seraphine
33.3%
VS
Vayne
66.7%
Vayne

Who wins Seraphine vs Vayne?

Too few games to callInsufficient data

Seraphine wins 33.3% of these games. With this many games the true rate is most likely between 15.2% and 58.3% (95% range).

Expected
51.1%
From both champions' overall Bot win rates
Matchup effect
−17.7 pts
Observed minus expected
Sample
15 games
Lane: Bot
vs patch 26.18
—
Not enough games on both patches

Lane: Bot · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.19 · Sep 24 – Sep 28

Key takeaways

  • Only 15 Seraphine vs Vayne games were recorded in the Bot role on patch 26.19 — too few to say who is favored. Treat the numbers below as provisional.
How we calculate this

Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.

A game only counts when Seraphine and Vayne played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.

The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.

Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.

"What changes" compares Seraphine's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).

Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.

Seraphine vs Vayne Laning Stats

SeraphineVayne

Only 14 games have a 15-minute snapshot so far — the lane-phase numbers appear from 30.

Whole-game averages

6.0
CS / min
6.5
720
DMG / min
812
11,687
Gold / game
13,205
125
Heal / min
190
364
DMG Mitigated / min
443
1.3
CC / min
0.3

Seraphine vs Vayne Win Rate by Game Length

Seraphine's win rate against Vayne by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.

Too few games
Under 20 min
2 games
Too few games
20–25 min
2 games
Too few games
25–30 min
4 games
Too few games
30–35 min
3 games
Too few games
35+ min
4 games
Seraphine vs Vayne95% rangeSeraphine usual (Bot)

No game length stands out: Seraphine's results against Vayne in short and long games are within the margin of error of each other.

Seraphine vs Vayne Power Spikes

Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.

  1. Lane (15 min)Insufficient data
  2. First itemInsufficient data
  3. Games under 20 minInsufficient data
  4. 20–30 min gamesInsufficient data
  5. 30+ min gamesInsufficient data

What Seraphine Changes Against Vayne

Only 15 games so far — too few to compare what Seraphine players do in this matchup with their usual choices (needs 20).

Best Seraphine Build vs Vayne

Usual Seraphine build (Bot)

59.5% win rate · 37 games

Against Vayne

Not enough matchup-specific build data: only 0 of 15 Seraphine games against Vayne carried a complete build, which is too few to recommend an item path from. Use Seraphine's standard build instead.

Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.

Best Seraphine Runes vs Vayne

Usual Seraphine runes (Bot)

Arcane CometArcane Comet
Sorcery
Manaflow BandTranscendenceGathering Storm
Precision
Presence of MindLegend: Haste
Ability Haste (offense)Adaptive Force (flex)Health (defense)

66.7% win rate · 21 games

Against Vayne

Too few games for a matchup-specific rune page yet — use the usual page.

MetaBot Desktop

Plan your Seraphine draft in Draft Lab

Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.

  • Full 5v5 draft board
  • Lane matchup win rates
  • Pick and ban suggestions
Draft Lab in MetaBot Desktop

Seraphine matchup data for League of Legends patch 26.19. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Other Seraphine Matchups

Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.

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Seraphine vs Vayne FAQ - Patch 26.19

Who wins Seraphine vs Vayne?

Only 15 Seraphine vs Vayne games were recorded in the Bot role on patch 26.19 — too few to say who is favored. Treat the numbers below as provisional.

What is Seraphine's win rate against Vayne?

Seraphine wins 33.3% of 15 Bot games against Vayne on patch 26.19 (95% range 15.2–58.3%). Based on both champions' overall Bot win rates, 51.1% would be expected.

Does Seraphine counter Vayne?

There are only 15 Seraphine vs Vayne games in this lane on patch 26.19 — too few to answer reliably yet.

Who wins lane, Seraphine or Vayne?

There are not enough games with a 15-minute snapshot yet (14) to say who wins lane.

Does Seraphine outscale Vayne?

There are too few games of each length to tell yet.

When is Vayne strongest against Seraphine?

On current data there is no stage of the game where Vayne is ahead of Seraphine beyond the margin of error.

What should Seraphine build against Vayne?

There are not enough games for a matchup-specific core, so use Seraphine's usual Bot core: Imperial Mandate, Rylai's Crystal Scepter, Blackfire Torch.

What runes should Seraphine use against Vayne?

Use Seraphine's usual Arcane Comet page (Sorcery + Precision); there are too few games for a matchup-specific page.