Seraphinevs Vayne
Seraphine vs Vayne is a decisive matchup in LoL patch 26.11. Seraphine wins with a 56.7% win rate (+13.3%) over Vayne based on 30 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Vayne matchup.
Seraphine Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Seraphine vs Vayne Matchup?
Seraphine vs Vayne Matchup Summary
The Seraphine vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 30 recent matches analyzed, Seraphine wins with a 56.7% win rate compared to Vayne's 43.3%, giving Seraphine a 13.3 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Seraphine leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Seraphine vs Vayne Laning Phase Breakdown
Vayne is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.
Early Game vs Late Game
Seraphine62.5%
Vayne37.5%Seraphine50.0%Vayne50.0%Seraphine dominates the early game (first 15 minutes) with a commanding 62.5% win rate — a 25.0 percentage point lead over Vayne. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Late game (25+ minutes) is equally balanced, with Seraphine at 50.0% win rate — only 0.0 points ahead of Vayne. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Seraphine Runes Against Vayne
Sorcery
Inspiration
Running Sorcery primary with Inspiration secondary allows Seraphine to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Seraphine matchup data for League of Legends patch 26.11. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 47.75% | 779 | 1.7 | 466 | 9,359 | 44.9% | 49.5% | |
| 50.91% | 550 | 1.4 | 493 | 9,173 | 58.0% | 45.0% | |
| 49.45% | 548 | 1.4 | 487 | 9,007 | 51.2% | 48.0% | |
| 50.83% | 543 | 1.4 | 487 | 9,197 | 46.8% | 53.9% | |
| 52.69% | 501 | 1.5 | 497 | 9,352 | 48.8% | 55.5% | |
| 50.21% | 478 | 1.8 | 526 | 9,255 | 51.6% | 49.0% | |
| 48.69% | 421 | 1.5 | 470 | 9,012 | 49.2% | 48.3% | |
| 50.00% | 334 | 1.4 | 453 | 9,010 | 50.4% | 49.7% | |
| 50.91% | 330 | 1.9 | 524 | 9,715 | 53.4% | 49.2% | |
| 51.72% | 319 | 1.4 | 469 | 9,560 | 46.7% | 55.4% | |
| 52.44% | 307 | 1.4 | 493 | 8,930 | 52.7% | 52.2% | |
| 53.17% | 284 | 1.7 | 483 | 9,531 | 47.7% | 56.6% | |
| 52.84% | 282 | 1.4 | 487 | 8,901 | 49.2% | 55.8% | |
| 50.78% | 258 | 1.5 | 444 | 9,247 | 50.5% | 51.0% | |
| 47.97% | 246 | 1.5 | 466 | 9,327 | 44.7% | 50.4% | |
| 54.85% | 237 | 1.8 | 584 | 9,764 | 54.8% | 54.9% | |
| 54.85% | 237 | 1.4 | 452 | 8,965 | 51.9% | 57.4% | |
| 53.07% | 228 | 1.5 | 391 | 8,663 | 58.8% | 46.8% | |
| 54.63% | 227 | 1.8 | 498 | 9,664 | 55.6% | 54.0% | |
| 43.13% | 211 | 1.3 | 502 | 8,901 | 35.6% | 48.8% | |
| 52.22% | 203 | 1.4 | 522 | 9,037 | 58.4% | 47.4% | |
| 43.22% | 199 | 1.5 | 498 | 8,961 | 47.1% | 40.4% | |
| 48.44% | 192 | 1.4 | 497 | 9,418 | 51.2% | 46.3% | |
| 53.45% | 174 | 1.8 | 462 | 9,232 | 49.4% | 56.7% | |
| 49.70% | 169 | 1.6 | 614 | 9,703 | 44.4% | 52.2% | |
| 52.26% | 155 | 1.4 | 479 | 9,118 | 56.9% | 48.2% | |
| 57.53% | 146 | 1.4 | 569 | 9,690 | 67.9% | 51.1% | |
| 54.48% | 145 | 4.5 | 662 | 11,521 | 62.3% | 50.0% | |
| 52.52% | 139 | 1.4 | 489 | 9,051 | 64.1% | 42.7% | |
| 61.29% | 124 | 1.6 | 481 | 9,075 | 67.7% | 54.8% | |
| 50.00% | 122 | 1.4 | 462 | 8,512 | 50.8% | 49.1% | |
| 50.00% | 120 | 1.4 | 508 | 9,232 | 52.8% | 47.8% | |
| 51.30% | 115 | 1.4 | 463 | 8,905 | 42.2% | 57.1% | |
| 59.13% | 115 | 6.2 | 814 | 12,230 | 54.7% | 62.9% | |
| 53.49% | 86 | 1.5 | 480 | 9,035 | 67.5% | 41.3% | |
| 54.88% | 82 | 5.8 | 677 | 11,898 | 60.0% | 51.9% | |
| 61.25% | 80 | 4.8 | 789 | 12,002 | 75.9% | 52.9% | |
| 56.76% | 74 | 6.8 | 807 | 12,478 | 63.9% | 50.0% | |
| 53.42% | 73 | 2.0 | 510 | 9,991 | 52.0% | 54.2% | |
| 56.16% | 73 | 1.5 | 514 | 9,449 | 56.8% | 55.6% | |
| 46.88% | 64 | 1.5 | 467 | 9,510 | 52.0% | 43.6% | |
| 43.33% | 60 | 1.6 | 557 | 9,121 | 60.7% | 28.1% | |
| 48.33% | 60 | 2.1 | 440 | 8,595 | 48.3% | 48.4% | |
| 54.24% | 59 | 6.2 | 831 | 12,840 | 42.1% | 60.0% | |
| 54.24% | 59 | 3.3 | 592 | 10,058 | 60.9% | 50.0% | |
| 60.34% | 58 | 5.3 | 751 | 11,906 | 51.9% | 67.7% | |
| 63.16% | 57 | 2.0 | 567 | 10,732 | 79.0% | 55.3% | |
| 44.23% | 52 | 1.7 | 575 | 9,420 | 52.0% | 37.0% | |
| 51.06% | 47 | 2.0 | 462 | 9,108 | 47.6% | 53.9% | |
| 50.00% | 40 | 2.2 | 608 | 10,026 | 52.6% | 47.6% | |
| 56.76% | 37 | 6.3 | 891 | 12,395 | 62.5% | 52.4% | |
| 44.44% | 36 | 2.5 | 515 | 9,087 | 30.8% | 52.2% | |
| 60.61% | 33 | 4.2 | 598 | 11,534 | 55.6% | 62.5% | |
| 51.52% | 33 | 5.3 | 666 | 11,600 | 61.5% | 45.0% | |
| 42.42% | 33 | 6.2 | 813 | 10,735 | 42.1% | 42.9% | |
| 51.52% | 33 | 6.8 | 787 | 11,426 | 58.8% | 43.8% | |
| 65.63% | 32 | 1.6 | 474 | 9,163 | 73.3% | 58.8% | |
| 65.63% | 32 | 4.1 | 681 | 10,156 | 66.7% | 64.7% | |
| 58.06% | 31 | 1.6 | 485 | 9,799 | 66.7% | 52.6% | |
| 56.67% | 30 | 6.6 | 733 | 10,933 | 62.5% | 50.0% | |
| 41.38% | 29 | 1.4 | 501 | 9,366 | 30.8% | 50.0% | |
| 44.44% | 27 | 5.1 | 677 | 10,722 | 63.6% | 31.3% | |
| 62.96% | 27 | 1.6 | 498 | 10,328 | 62.5% | 63.2% | |
| 54.17% | 24 | 4.2 | 624 | 9,656 | 45.5% | 61.5% | |
| 50.00% | 22 | 2.4 | 567 | 9,749 | 40.0% | 58.3% | |
| 45.45% | 22 | 3.0 | 490 | 9,418 | 25.0% | 57.1% | |
| 63.64% | 22 | 2.2 | 508 | 11,567 | 60.0% | 64.7% | |
| 40.00% | 20 | 6.5 | 801 | 13,556 | 33.3% | 41.2% | |
| 55.00% | 20 | 6.7 | 792 | 12,479 | 66.7% | 45.5% | |
| 55.00% | 20 | 2.0 | 462 | 9,458 | 57.1% | 53.9% | |
| 45.00% | 20 | 5.8 | 714 | 11,072 | 40.0% | 50.0% | |
| 70.00% | 20 | 1.4 | 645 | 10,698 | 87.5% | 58.3% | |
| 63.16% | 19 | 1.4 | 434 | 10,160 | 60.0% | 64.3% | |
| 61.11% | 18 | 5.6 | 703 | 8,059 | 64.3% | 50.0% | |
| 58.82% | 17 | 6.2 | 865 | 12,026 | 50.0% | 63.6% | |
| 35.29% | 17 | 1.2 | 446 | 10,237 | 75.0% | 23.1% | |
| 75.00% | 16 | 6.7 | 918 | 13,627 | 71.4% | 77.8% | |
| 37.50% | 16 | 1.5 | 479 | 8,928 | 40.0% | 36.4% | |
| 60.00% | 15 | 6.7 | 761 | 12,988 | 66.7% | 55.6% | |
| 40.00% | 15 | 5.3 | 597 | 10,546 | 33.3% | 44.4% | |
| 60.00% | 15 | 1.6 | 463 | 10,507 | 75.0% | 54.5% | |
| 50.00% | 14 | 3.2 | 647 | 10,328 | 50.0% | 50.0% | |
| 50.00% | 14 | 2.6 | 551 | 9,742 | 50.0% | 50.0% | |
| 42.86% | 14 | 4.8 | 584 | 9,774 | 50.0% | 37.5% | |
| 53.85% | 13 | 6.3 | 921 | 12,200 | 66.7% | 42.9% | |
| 30.77% | 13 | 4.1 | 603 | 9,877 | 33.3% | 28.6% | |
| 61.54% | 13 | 3.1 | 594 | 9,468 | 42.9% | 83.3% | |
| 58.33% | 12 | 6.7 | 825 | 9,196 | 70.0% | 0.0% | |
| 50.00% | 12 | 4.3 | 666 | 9,424 | 33.3% | 66.7% | |
| 58.33% | 12 | 6.0 | 764 | 11,191 | 60.0% | 57.1% | |
| 72.73% | 11 | 6.1 | 758 | 11,907 | 100.0% | 66.7% | |
| 27.27% | 11 | 4.5 | 549 | 9,363 | 0.0% | 50.0% | |
| 54.55% | 11 | 6.2 | 660 | 11,060 | 50.0% | 60.0% | |
| 60.00% | 10 | 5.6 | 803 | 11,242 | 50.0% | 75.0% | |
| 80.00% | 10 | 1.4 | 477 | 7,161 | 87.5% | 50.0% | |
| 66.67% | 9 | 4.5 | 521 | 10,244 | 100.0% | 62.5% | |
| 44.44% | 9 | 1.8 | 423 | 8,693 | 66.7% | 33.3% | |
| 37.50% | 8 | 6.2 | 930 | 11,957 | 40.0% | 33.3% | |
| 62.50% | 8 | 1.6 | 623 | 9,742 | 33.3% | 80.0% | |
| 37.50% | 8 | 1.5 | 395 | 8,010 | 25.0% | 50.0% | |
| 37.50% | 8 | 1.3 | 467 | 9,596 | 25.0% | 50.0% | |
| 25.00% | 8 | 5.3 | 670 | 10,068 | 50.0% | 16.7% | |
| 25.00% | 8 | 3.4 | 577 | 9,673 | 25.0% | 25.0% | |
| 62.50% | 8 | 1.4 | 570 | 11,774 | 0.0% | 71.4% | |
| 75.00% | 8 | 5.4 | 707 | 11,288 | 50.0% | 83.3% | |
| 50.00% | 8 | 1.1 | 463 | 8,690 | 50.0% | 50.0% | |
| 50.00% | 8 | 6.2 | 987 | 13,253 | 66.7% | 40.0% | |
| 75.00% | 8 | 1.6 | 487 | 10,735 | 50.0% | 83.3% | |
| 85.71% | 7 | 1.4 | 537 | 8,417 | 100.0% | 0.0% | |
| 42.86% | 7 | 1.9 | 492 | 10,031 | 33.3% | 50.0% | |
| 71.43% | 7 | 3.1 | 635 | 10,657 | 100.0% | 60.0% | |
| 57.14% | 7 | 3.4 | 739 | 12,184 | 100.0% | 50.0% | |
| 100.00% | 7 | 3.1 | 595 | 7,466 | 100.0% | 100.0% | |
| 71.43% | 7 | 3.0 | 520 | 8,011 | 75.0% | 66.7% | |
| 33.33% | 6 | 7.3 | 822 | 10,976 | 25.0% | 50.0% | |
| 100.00% | 6 | 2.3 | 548 | 9,903 | 100.0% | 100.0% | |
| 83.33% | 6 | 2.2 | 474 | 10,918 | 100.0% | 80.0% | |
| 50.00% | 6 | 1.6 | 382 | 9,863 | 50.0% | 50.0% | |
| 100.00% | 5 | 5.9 | 570 | 11,549 | 0.0% | 100.0% | |
| 40.00% | 5 | 1.6 | 496 | 10,447 | 50.0% | 33.3% | |
| 60.00% | 5 | 1.2 | 565 | 10,300 | 0.0% | 75.0% | |
| 40.00% | 5 | 6.0 | 646 | 9,774 | 25.0% | 100.0% | |
| 40.00% | 5 | 3.8 | 646 | 10,549 | 66.7% | 0.0% | |
| 80.00% | 5 | 1.5 | 499 | 10,155 | 50.0% | 100.0% | |
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Seraphine vs Vayne - Frequently Asked Questions
How does Seraphine do against Vayne in League of Legends?
Seraphine wins the Seraphine vs Vayne matchup with a 56.7% win rate compared to Vayne's 43.3%, a 13.3 percentage point difference. This data is based on 30 recent ranked games in patch 26.11.
How does Seraphine do against Vayne in the early game?
In the early game, Seraphine has the advantage against Vayne with a 62.5% win rate versus 37.5%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Seraphine do against Vayne in the late game?
In the late game, Seraphine takes over the Seraphine vs Vayne matchup with a 50.0% win rate compared to 50.0%. Seraphine scales better into team fights and objective contests after 25 minutes.
Who wins the Seraphine vs Vayne matchup?
Seraphine wins the matchup against Vayne with a 56.7% win rate in League of Legends patch 26.11. The 13.3 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 30 games analyzed.
What is the best Seraphine build against Vayne?
The best Seraphine build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Seraphine runes against Vayne?
The best Seraphine runes against Vayne use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Seraphine counter Vayne?
Yes, Seraphine has a favorable matchup against Vayne with a 56.7% win rate. Seraphine strongly counters Vayne in lane based on current patch 26.11 data.
How do I play Seraphine against Vayne?
When playing Seraphine against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.