Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

Seraphinevs Zoe

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 23, 2026
MethodologyData Methodology

Seraphine vs Zoe is a decisive matchup in LoL patch 26.7. Zoe wins with a 80.0% win rate (+60.0%) over Seraphine based on 10 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Zoe matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zoe - 20.0% win rateZoe(20.0%)
Seraphine - 20.0% win rate in this matchup
Seraphine
20.0% WR
VS
Zoe vs Seraphine matchup - 80.0% win rate
Zoe
80.0% WR

Who Wins the Seraphine vs Zoe Matchup?

Zoe wins the Seraphine vs Zoe matchup
Winner
Zoe
Matches: 10
20.0%
Win Rate
80.0%
1.9
CS / min
2.1
444
DMG / min
819
9,657
Gold / game
11,386
297
Heal / min
138
406
DMG Mitigated / min
305
1.2
CC / min
1.5
0.0%
Early Game WR
100.0%
40.0%
Late Game WR
60.0%

Seraphine vs Zoe Matchup Summary

The Seraphine vs Zoe matchup is a decisive matchup in League of Legends ranked play. Based on 10 recent matches analyzed, Zoe wins with a 80.0% win rate compared to Seraphine's 20.0%, giving Zoe a 60.0 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Seraphine players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in damage output, where Zoe leads by 376 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe has a strong advantage in this matchup. Seraphine players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zoe overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Zoe Laning Phase Breakdown

Zoe wins the laning phase against Seraphine in League of Legends

Zoe is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Zoe holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.9Seraphine
2.1Zoe
Seraphine and Zoe farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
444Seraphine
819Zoe
Zoe heavily out-damages Seraphine by 376 DMG/min, dominating both short trades and all-in fights. Seraphine should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zoe's sustained damage advantage take over.
Economy
9,657Seraphine
11,386Zoe
Zoe generates a commanding 1,729 more gold per game than Seraphine. This substantial economic advantage means Zoe consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.2Seraphine
1.5Zoe
Zoe provides 0.3 seconds more crowd control per minute than Seraphine, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Zoe coordinate with their jungler and control the pace of skirmishes.
Sustain
704Seraphine
442Zoe
Seraphine vastly out-sustains Zoe, healing and mitigating 262 more damage per minute. This massive durability gap means Seraphine can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Seraphine Build Against Zoe

Ionian Boots of Lucidity is the optimal boots choice against Zoe, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Zoe are Echoes of Helia, Moonstone Renewer and Diadem of Songs. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Zoe matchup.

Early Game vs Late Game

Early Game
Zoe
100.0%
+100.0% advantage
Seraphine early game win rateSeraphine0.0%
Zoe early game win rateZoe100.0%
Late Game
Zoe
60.0%
+20.0% advantage
Seraphine late game win rateSeraphine40.0%
Zoe late game win rateZoe60.0%

Zoe dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Seraphine. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zoe is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Seraphine. Extended games heavily favor Zoe, whose kit and scaling make them a dominant force in team fights and objective control.

Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Seraphine players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Zoe

Sorcery rune tree - Seraphine primary runes vs ZoeSorcery
Arcane Comet - best Seraphine rune vs ZoeManaflow Band - best Seraphine rune vs ZoeTranscendence - best Seraphine rune vs ZoeGathering Storm - best Seraphine rune vs Zoe
Resolve rune tree - Seraphine secondary runes vs ZoeResolve
Shield Bash - best Seraphine rune vs ZoeRevitalize - best Seraphine rune vs Zoe
100.0% WR

The Sorcery and Resolve rune setup gives Seraphine the best tools to compete against Zoe in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Seraphine matchup data for League of Legends patch 26.7. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
54.18%2991.64439,72745.0%59.6%
44.49%2631.34388,73041.4%48.0%
53.94%2411.34619,24352.6%55.2%
53.01%1831.44589,30748.8%56.4%
53.59%1811.44469,09849.4%57.5%
53.66%1641.44779,15159.3%48.2%
51.57%1591.54879,18454.3%49.4%
56.96%1581.44609,12365.1%51.6%
51.45%1381.44108,92450.8%52.1%
57.58%1321.44559,01657.4%57.8%
44.44%1261.34078,50942.9%46.0%
48.72%1171.655210,13343.2%51.3%
55.17%1161.54939,75339.1%65.7%
48.28%1161.754110,06752.2%45.7%
54.29%1051.34268,52558.2%50.0%
47.57%1031.54449,60136.6%54.8%
53.92%1021.44648,93753.9%54.0%
50.50%1011.43578,58654.9%46.0%
65.31%982.04699,74265.0%65.5%
51.11%901.45449,00546.1%54.9%
60.67%891.45258,87651.2%69.6%
48.05%771.64329,06447.1%48.8%
48.48%661.64499,83052.0%46.3%
56.06%661.446210,05756.0%56.1%
59.09%661.34709,19553.3%63.9%
51.52%661.45339,38642.9%57.9%
50.00%561.34318,78350.0%50.0%
50.91%555.059410,15445.7%60.0%
61.11%541.45039,73561.1%61.1%
45.10%511.45549,19748.0%42.3%
56.00%501.64589,66571.4%44.8%
68.09%471.34338,79683.3%52.2%
41.30%461.44408,44340.7%42.1%
55.26%386.575312,73061.1%50.0%
41.67%361.55229,34566.7%23.8%
45.71%351.45389,51041.2%50.0%
51.43%356.577612,68062.5%42.1%
41.18%341.95239,70342.9%40.0%
62.50%324.466312,14861.5%63.2%
61.54%261.45069,89770.0%56.3%
57.69%265.866912,09666.7%50.0%
72.00%253.654911,21477.8%68.8%
47.83%231.34387,54662.5%14.3%
39.13%231.34279,80042.9%37.5%
45.45%225.768813,31257.1%40.0%
42.86%212.04569,77930.0%54.5%
60.00%206.873212,63062.5%58.3%
68.42%192.25288,37271.4%60.0%
52.63%194.566310,72362.5%45.5%
77.78%185.262111,90780.0%75.0%
50.00%182.23929,53214.3%72.7%
17.65%171.95419,5550.0%30.0%
68.75%166.175711,132100.0%44.4%
56.25%165.061711,17950.0%58.3%
37.50%161.44408,74328.6%44.4%
40.00%155.879112,89180.0%20.0%
53.33%152.65158,83558.3%33.3%
60.00%156.969012,35375.0%42.9%
57.14%141.65038,97662.5%50.0%
50.00%126.066912,17266.7%33.3%
58.33%121.95109,80057.1%60.0%
41.67%124.362911,9680.0%50.0%
50.00%125.572511,57837.5%75.0%
45.45%111.83348,40757.1%25.0%
45.45%111.448611,0260.0%50.0%
20.00%101.94449,6570.0%40.0%
30.00%106.083411,91850.0%16.7%
66.67%95.04869,88271.4%50.0%
66.67%96.791812,31350.0%100.0%
44.44%91.652310,69633.3%50.0%
66.67%95.06849,58460.0%75.0%
55.56%95.878611,74075.0%40.0%
62.50%86.375213,234100.0%50.0%
62.50%84.164710,851100.0%0.0%
62.50%86.072611,59850.0%75.0%
50.00%81.63948,88825.0%75.0%
50.00%82.659011,57450.0%50.0%
37.50%84.34689,60866.7%20.0%
50.00%86.075212,12750.0%50.0%
75.00%81.84619,71750.0%100.0%
50.00%84.75939,70720.0%100.0%
28.57%71.54699,3480.0%50.0%
57.14%72.24578,64566.7%50.0%
85.71%71.55068,91275.0%100.0%
42.86%71.44499,4630.0%60.0%
50.00%63.866510,38850.0%50.0%
50.00%61.253910,07150.0%50.0%
50.00%62.45769,27866.7%33.3%
50.00%65.060611,31766.7%33.3%
40.00%56.077711,01533.3%50.0%
20.00%55.151210,8920.0%25.0%
60.00%55.872310,033100.0%50.0%
20.00%51.43949,2580.0%33.3%
80.00%54.677910,15775.0%100.0%
40.00%52.76589,47233.3%50.0%

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Seraphine vs Zoe - Frequently Asked Questions

How does Seraphine do against Zoe in League of Legends?

Zoe wins the Seraphine vs Zoe matchup with a 80.0% win rate compared to Seraphine's 20.0%, a 60.0 percentage point difference. This data is based on 10 recent ranked games in patch 26.7.

How does Seraphine do against Zoe in the early game?

In the early game, Zoe has the advantage against Seraphine with a 100.0% win rate versus 0.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Zoe in the late game?

In the late game, Zoe takes over the Seraphine vs Zoe matchup with a 60.0% win rate compared to 40.0%. Zoe scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Zoe matchup?

Zoe wins the matchup against Seraphine with a 80.0% win rate in League of Legends patch 26.7. The 60.0 percentage point advantage means Zoe is significantly favored in this lane matchup based on 10 games analyzed.

What is the best Seraphine build against Zoe?

The best Seraphine build against Zoe includes Echoes of Helia, Moonstone Renewer, Diadem of Songs with Ionian Boots of Lucidity. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Zoe?

The best Seraphine runes against Zoe use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Zoe matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Zoe?

No, Seraphine struggles against Zoe with only a 20.0% win rate. Zoe has the advantage in this matchup. Seraphine players should focus on safe farming and avoiding extended trades to minimize Zoe's lead.

How do I play Seraphine against Zoe?

When playing Seraphine against Zoe, play cautiously and avoid Zoe's power spikes. Look for jungle assistance and team-dependent plays since Zoe has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.