Shame Curse

Is Shame good in Slay the Spire 2?

Shame is a curse Curse curse in Slay the Spire 2. In combat it resolves as: At the end of your turn, if this is in your Hand, gain Frail. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 120 recorded runs, decks running it win 36.1% of the time, comfortably clear of the 13.8% average, by 22.3%. It’s a more selective pick, turning up in just 0.5% of decks that could run it. Regent players keep it in 0.5% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.3 times in the decks that take it.

It performs best next to Falling Star — together they post a +4.7% swing in win rate. It also has strong chemistry with the relic Venerable Tea Set, which moves its win rate by +30.4%. At - energy, it’s upgraded in 0.0% of runs and usually joins the deck around floor 21.

That’s 43 wins, 76 deaths, and 1 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Aeonglass Boss, which closes out 5.8% of its appearances. Read on for Shame’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Curse run.

When to Pick Up Shame

Shame is strongest when it joins the deck in Act 3, where runs win 55.9% across 59 runs — one of 2 recorded pickup windows.

Win rate of runs by the act Shame entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Shame

Ranked by win-rate lift, Shame performs best alongside Falling Star (+4.7%), Defend (+4.7%), and Clumsy (+3.4%).

Falling Star+4.7%16 runsDefend+4.7%16 runsClumsy+3.4%27 runsDefend+2.3%29 runsNeutralize+2.3%29 runsSurvivor+2.3%29 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Shame Win Rate by Class

Shame is played across 5 classes, led by Regent (52.4%), Silent (37.9%), and Necrobinder (33.3%) by win rate.

The Regent52.4%21 runsThe Silent37.9%30 runsThe Necrobinder33.3%24 runsThe Ironclad30.8%26 runsThe Defect26.3%19 runs

Best Relics for Shame

Shame pairs best with the relics Venerable Tea Set (+30.4%), Potion Belt (+30.3%), and Regal Pillow (+22.3%), ranked by win-rate lift.

Venerable Tea Set+30.4%21 runsPotion Belt+30.3%18 runsRegal Pillow+22.3%27 runsBag of Marbles+20.7%21 runsPendulum+20.3%23 runsMeal Ticket+20.1%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Shame Card Details

Shame is a curse curse costing - energy; it’s upgraded in 0.0% of runs and usually picked up by floor 21.

At the end of your turn, if this is in your Hand, gain Frail.

What Ends Runs with Shame

Shame’s most common run-enders are Aeonglass Boss (5.8%), Queen Boss (4.2%), and Test Subject Boss (4.2%).

• Aeonglass Boss5.8% of runs
• Queen Boss4.2% of runs
• Test Subject Boss4.2% of runs
• The Kin Boss3.3% of runs
• Soul Fysh Boss2.5% of runs

See Also

Compare Shame with the rest of the best Slay the Spire 2 cards, relics, and classes below.