Vayne, League of Legends champion
Win Rate
48.9%
Pick Rate
0.8%
Ban Rate
6.5%

Vayne Top Runes: Keystone & Shards

Vayne F TierMarksmanAssassin
Patch
26.19
Games
1,562
Lane
Top
Tier
All Tiers
Last Updated
Oct 8, 2026 UTC
Methodology
Data Methodology

Best Top Vayne runes for LoL Patch 26.19 - Press the Attack from the Precision tree with Resolve secondary (50.2% WR, 17.3% pick rate). Vayne's optimal primary runes are Press the Attack, Triumph, Legend: Alacrity, Coup de Grace. Secondary tree: Conditioning, Overgrowth.

Vayne performs best with Press the Attack as the keystone rune from the Precision tree. Vayne's optimal primary runes are Press the Attack, Triumph, Legend: Alacrity, Coup de Grace. Vayne's secondary rune tree is Resolve with Conditioning, Overgrowth. This rune setup achieves a 50.18% win rate (+1.3% win rate difference) with a 17.3% pick rate across 271 Vayne games.
50.2%Win Rate
+1.3%WR Diff
17.3%Pick Rate
Press the AttackPress the Attack

Hitting an enemy champion with 3 consecutive basic attacks deals 40 - 160 bonus adaptive damage (based on level) and amplifies your damage dealt by 8% until you leave combat with champions.

TriumphTriumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.



'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Legend: AlacrityLegend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Coup de GraceCoup de Grace

Deal 8% more damage to champions who have less than 40% health.

ConditioningConditioning

After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 3%.

OvergrowthOvergrowth

Absorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.

When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.

This alternative Vayne rune build uses Lethal Tempo as the keystone from the Precision tree. The primary runes are Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace. Vayne's secondary rune tree is Resolve with Conditioning, Overgrowth. This setup achieves a 47.33% win rate (-1.6% win rate difference) with a 47.9% pick rate across 748 games.
47.3%Win Rate
-1.6%WR Diff
47.9%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

TriumphTriumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.



'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Legend: AlacrityLegend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Coup de GraceCoup de Grace

Deal 8% more damage to champions who have less than 40% health.

ConditioningConditioning

After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 3%.

OvergrowthOvergrowth

Absorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.

When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.

These champions share at least 4 runes with Vayne's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Vayne's playstyle or want to learn champions with familiar rune setups.Varus, Teemo

Every Vayne Top Keystone and Secondary Tree (Patch 26.19)

1,473 games

Vayne Top runs Lethal Tempo in 65% of games, with a 48.6% win rate. Resolve is the usual secondary tree (75%). Standard stat shards: Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense).

Keystones

RunePlayersWin RateGames
Lethal TempoLethal TempoMost played64.8%48.6%954
Press the AttackPress the Attack23.4%48.8%344
Fleet FootworkFleet Footwork10.2%46.7%150

Secondary trees

RunePlayersWin RateGames
ResolveResolveMost played75.2%48.2%1,107
SorcerySorcery14.1%47.3%207
DominationDomination7.5%54.1%111

Pick rate is the share of Vayne games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.

Vayne Minor Runes by Tree

Every minor rune Vayne players take, grouped by rune tree, with how often it is picked and how often it wins.

Precision

RunePlayersWin RateGames
Legend: AlacrityLegend: AlacrityMost played95.7%48.2%1,409
TriumphTriumph84.0%48.3%1,237
Coup de GraceCoup de Grace79.3%48.4%1,168
Cut DownCut Down17.7%50.4%260
Absorb LifeAbsorb Life10.6%48.1%156
Presence of MindPresence of Mind4.5%50.7%67

Resolve

RunePlayersWin RateGames
OvergrowthOvergrowthMost played74.6%48.3%1,099
ConditioningConditioning70.1%48.4%1,032
Bone PlatingBone Plating3.9%48.3%58

Sorcery

RunePlayersWin RateGames
CelerityCelerityMost played12.8%48.4%188
Nimbus CloakNimbus Cloak11.7%49.4%172

Domination

RunePlayersWin RateGames
Sudden ImpactSudden ImpactMost played5.2%54.5%77
Ultimate HunterUltimate Hunter4.1%50.8%61
Treasure HunterTreasure Hunter2.9%55.8%43
Taste of BloodTaste of Blood2.8%56.1%41

Vayne Stat Shards

Which stat shards Vayne players choose in each of the three shard rows, and the win rate of each.

RunePlayersWin RateGames
Attack Speed (offense)Attack Speed (offense)Most played98.4%48.6%1,450
Adaptive Force (flex)Adaptive Force (flex)97.2%48.6%1,432
Health Scaling (defense)Health Scaling (defense)88.3%48.4%1,301
Health (defense)Health (defense)7.9%50.9%116
Tenacity and Slow Resist (defense)Tenacity and Slow Resist (defense)3.8%50.0%56
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Vayne Runes FAQ - Patch 26.19

What is the best keystone for Vayne Top?

Lethal Tempo: Vayne Top takes it in 65% of ranked games and wins 48.6% of 954 games. Alternatives: Press the Attack (23%, 48.8%), Fleet Footwork (10%, 46.7%).

What stat shards should Vayne take?

Most Vayne players take Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.

What are the best Vayne runes in patch 26.19?

The best Vayne runes in patch 26.19 use the Precision tree with Press the Attack, Triumph, Legend: Alacrity, and Coup de Grace, and the Resolve tree with Conditioning and Overgrowth. This rune setup achieves a 50.2% win rate with a 17.3% pick rate.

What is the win rate for Vayne's best rune page?

Vayne's best rune page has a 50.2% win rate in patch 26.19, which is +1.3% compared to Vayne's average win rate. This rune setup has a 17.3% pick rate among Vayne players.

What keystone should I use on Vayne?

Press the Attack from the Precision tree is the best keystone rune for Vayne in patch 26.19. This keystone synergizes well with Vayne's kit and provides a 50.2% win rate.

What is Vayne's primary rune tree?

Vayne's primary rune tree is Precision. The optimal Precision runes for Vayne are Press the Attack, Triumph, Legend: Alacrity, and Coup de Grace, with Press the Attack being the keystone of choice.

What is Vayne's secondary rune tree?

Vayne's best secondary rune tree is Resolve. The recommended Resolve runes are Conditioning and Overgrowth, which complement Vayne's Precision primary tree.

What are alternative rune setups for Vayne?

An alternative Vayne rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Vayne's runes?

Vayne's top rune page has a 17.3% pick rate in patch 26.19. This indicates that 17.3% of Vayne players use the Press the Attack setup with Precision and Resolve trees.