Caitlyn - League of Legends Champion
Win Rate
49.6%
Pick Rate
9.8%

CaitlynRunes

CMarksman
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 17, 2026
MethodologyData Methodology

Best Caitlyn runes for LoL Patch 26.5 - First Strike from the Inspiration tree with Sorcery secondary (77.8% WR, 0.1% pick rate). Caitlyn's optimal primary runes are First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight. Secondary tree: Gathering Storm, Absolute Focus.

Caitlyn performs best with First Strike as the keystone rune from the Inspiration tree. Caitlyn's optimal primary runes are First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight. Caitlyn's secondary rune tree is Sorcery with Gathering Storm, Absolute Focus. This rune setup achieves a 77.78% win rate (+28.2% win rate difference) with a 0.1% pick rate across 18 Caitlyn games.
77.8%Win Rate
+28.2%WR Diff
0.1%Pick Rate
First StrikeFirst Strike

Attacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 50% (35% for ranged champions) of bonus damage dealt as gold.

Cooldown: 25 - 15s

Magical FootwearMagical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Gathering StormGathering Storm

Every 10 min gain AP or AD, adaptive.

10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...

Absolute FocusAbsolute Focus

While above 70% health, gain an adaptive bonus of up to 18 Attack Damage or 30 Ability Power (based on level).

Grants 1.8 Attack Damage or 3 Ability Power at level 1.

This alternative Caitlyn rune build uses Fleet Footwork as the keystone from the Precision tree. The primary runes are Fleet Footwork, Presence of Mind, Legend: Bloodline, Coup de Grace. Caitlyn's secondary rune tree is Inspiration with Cash Back, Triple Tonic. This setup achieves a 76.47% win rate (+26.9% win rate difference) with a 0.1% pick rate across 17 games.
76.5%Win Rate
+26.9%WR Diff
0.1%Pick Rate
Fleet FootworkFleet Footwork

Attacking and moving builds Energy stacks. At 100 stacks, your next attack is Energized

Energized attacks heal you for 10 - 130 (+0.1 Bonus AD, +0.05 AP) and grant 20% Move Speed for 1s.

For Ranged Champions, Healing is 60% effective and Move Speed is 75% effective. All healing is 15% effective against Minions.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Legend: BloodlineLegend: Bloodline

Gain 0.45% Life Steal for every Legend stack (max 15 stacks). At maximum Legend stacks, gain 85 max health.

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Coup de GraceCoup de Grace

Deal 8% more damage to champions who have less than 40% health.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

These champions share at least 4 runes with Caitlyn's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Caitlyn's playstyle or want to learn champions with familiar rune setups.Miss Fortune, Senna, Jhin, Viktor, Ezreal and 1 other

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Caitlyn Runes - Frequently Asked Questions

What are the best Caitlyn runes in patch 26.5?

The best Caitlyn runes in patch 26.5 use the Inspiration tree with First Strike, Magical Footwear, Biscuit Delivery, and Cosmic Insight, and the Sorcery tree with Gathering Storm and Absolute Focus. This rune setup achieves a 77.8% win rate with a 0.1% pick rate.

What is the win rate for Caitlyn's best rune page?

Caitlyn's best rune page has a 77.8% win rate in patch 26.5, which is +28.2% compared to Caitlyn's average win rate. This rune setup has a 0.1% pick rate among Caitlyn players.

What keystone should I use on Caitlyn?

First Strike from the Inspiration tree is the best keystone rune for Caitlyn in patch 26.5. This keystone synergizes well with Caitlyn's kit and provides a 77.8% win rate.

What is Caitlyn's primary rune tree?

Caitlyn's primary rune tree is Inspiration. The optimal Inspiration runes for Caitlyn are First Strike, Magical Footwear, Biscuit Delivery, and Cosmic Insight, with First Strike being the keystone of choice.

What is Caitlyn's secondary rune tree?

Caitlyn's best secondary rune tree is Sorcery. The recommended Sorcery runes are Gathering Storm and Absolute Focus, which complement Caitlyn's Inspiration primary tree.

What are alternative rune setups for Caitlyn?

An alternative Caitlyn rune setup uses alternative keystone from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Caitlyn's runes?

Caitlyn's top rune page has a 0.1% pick rate in patch 26.5. This indicates that 0.1% of Caitlyn players use the First Strike setup with Inspiration and Sorcery trees.