RegretCurse
At the end of your turn, if this is in your Hand, lose 1 HP for each card in your Hand.
Is Regret good in Slay the Spire 2?
In Slay the Spire 2, Regret is a curse curse from the Curse card pool. Its effect: At the end of your turn, if this is in your Hand, lose 1 HP for each card in your Hand. Right now it’s a premium pick that sits at S tier — one of the better cards you can add to a deck this run.
Over 37 tracked runs its win rate sits at 55.9%, 36.9% ahead of the 19.0% all-deck baseline. It sees niche play, included in only 1.0% of eligible runs. Within Ironclad runs it’s drafted 1.3% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.
Its standout pairing so far is Battle Trance, which lifts its win rate by +14.7% when the two share a deck. On the relic side, Toxic Egg is its standout companion, worth a +12.6% win-rate swing alongside it. It costs - energy, gets upgraded 0.0% of the time, and tends to be picked up near floor 35.
Of the runs that drafted it, 19 ended in victory against 15 deaths and 3 abandons. Its most common run-ender is Test Subject Boss, finishing 13.5% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Regret fits a Curse deck.
Regret Win Rate & Pick Rate
At a 55.9% win rate, Regret runs 36.9% ahead of the 19.0% all-deck baseline — the bars below put the two side by side.
Run Outcomes with Regret
Across the 37 tracked runs that drafted Regret, 19 ended in a win and 18 in a loss — a 51.4% win share, counting abandons as losses.
- Wins 51.4%
- Losses 48.6%
Best Cards to Pair with Regret
Regret’s strongest card pairings so far are Battle Trance (+14.7%), Setup Strike (+14.7%), and Anger (+12.6%), each shown with the win-rate lift it adds.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Regret Win Rate by Class
Of the 5 classes that draft Regret, it performs best with Ironclad (77.8%), Necrobinder (66.7%), and Silent (44.4%).
Best Relics for Regret
The relics that swing Regret’s win rate the most are Toxic Egg (+12.6%), Bag of Preparation (+12.3%), and Burning Blood (+12.3%), with each lift shown.
Toxic Egg4 runs
Bag of Preparation7 runs
Burning Blood7 runs
Reptile Trinket7 runs
Meal Ticket6 runs
Razor Tooth6 runsBased on small co-occurring samples — treat these as early signals, not final verdicts.
Regret Card Details
A --energy curse curse, Regret is upgraded 0.0% of the time and tends to enter the deck around floor 35.
At the end of your turn, if this is in your Hand, lose 1 HP for each card in your Hand.
What Ends Runs with Regret
Runs holding Regret end most often against Test Subject Boss (13.5%), Doormaker Boss (10.8%), and Queen Boss (10.8%) — the share of its runs each accounts for is shown.
- Test Subject Boss13.5% of runs
- Doormaker Boss10.8% of runs
- Queen Boss10.8% of runs
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Regret – Frequently Asked Questions
Is Regret good in Slay the Spire 2?
Across 37 tracked runs, Regret has a 55.9% win rate — +36.9% above the average deck. Win rate reflects how often runs that include the card end in victory.
What does Regret do in Slay the Spire 2?
Regret costs - energy. At the end of your turn, if this is in your Hand, lose 1 HP for each card in your Hand.
What class is Regret in Slay the Spire 2?
Regret is a Curse Curse Curse.
Is Regret worth upgrading in Slay the Spire 2?
Regret can be upgraded at a rest site to improve its effect.
What is the best relic for Regret?
In tracked runs, Regret has performed best alongside Toxic Egg, which lifts its win rate by +12.6% over 4 runs together.
See Also
Keep exploring Slay the Spire 2 tier lists and stats below.