Restlessness•Skill

Is Restlessness good in Slay the Spire 2?

Restlessness is an uncommon Colorless skill in Slay the Spire 2. In combat it resolves as: If your Hand is empty, draw cards and gain Energy. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 25 recorded runs, decks running it win 33.3% of the time, comfortably clear of the 18.9% average, by 14.4%. It’s a more selective pick, turning up in just 0.7% of decks that could run it. Silent players keep it in 1.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Infinite Blades — together they post a +18.8% swing in win rate. It also has strong chemistry with the relic Blood Vial, which moves its win rate by +18.8%. At 0 energy, it’s upgraded in 12.0% of runs and usually joins the deck around floor 15.

Upgraded, it gains +1 Cards, +1 Energy, which is why so many decks invest a rest-site upgrade in it. That’s 7 wins, 14 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is The Insatiable Boss, which closes out 8.0% of its appearances. Read on for Restlessness’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Best Cards to Pair with Restlessness

Ranked by win-rate lift, Restlessness performs best alongside Infinite Blades (+18.8%), Blade Dance (+15.7%), and Anticipate (+15.6%).

Infinite Blades+18.8%6 runsBlade Dance+15.7%7 runsAnticipate+15.6%5 runsAccuracy+15.6%5 runsExpose+15.4%3 runsMad Science+15.4%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Restlessness Win Rate by Class

Restlessness is played across 5 classes, led by Silent (55.6%), Defect (50.0%), and Necrobinder (16.7%) by win rate.

The Silent55.6%10 runsThe Defect50.0%2 runsThe Necrobinder16.7%6 runsThe Regent0.0%4 runsThe Ironclad0.0%3 runs

Best Relics for Restlessness

Restlessness pairs best with the relics Blood Vial (+18.8%), Red Mask (+15.4%), and Ornamental Fan (+15.4%), ranked by win-rate lift.

Blood Vial+18.8%7 runsRed Mask+15.4%3 runsOrnamental Fan+15.4%3 runsJuzu Bracelet+15.4%3 runsLooming Fruit+15.4%3 runsLantern+12.5%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Restlessness Card Details

Restlessness is an uncommon skill costing 0 energy; it’s upgraded in 12.0% of runs and usually picked up by floor 15.

If your Hand is empty, draw cards and gain Energy.

Upgrade: +1 Cards, +1 Energy

What Ends Runs with Restlessness

Restlessness’s most common run-enders are The Insatiable Boss (8.0%) and Knowledge Demon Boss (8.0%).

• The Insatiable Boss8.0% of runs
• Knowledge Demon Boss8.0% of runs

See Also

Compare Restlessness with the rest of the best Slay the Spire 2 cards, relics, and classes below.