Cassiopeia - League of Legends Champion
Win Rate
46.1%
Pick Rate
0.8%

Cassiopeiavs Zyra

FMage
Patch26.10
Matches1,627,927
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 20, 2026
MethodologyData Methodology

Cassiopeia vs Zyra is a decisive matchup in LoL patch 26.10. Zyra wins with a 60.0% win rate (+20.0%) over Cassiopeia based on 5 games. Cassiopeia wins the early laning phase while Zyra scales better into the late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Zyra matchup.

Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zyra - 40.0% win rateZyra(40.0%)
Cassiopeia - 40.0% win rate in this matchup
Cassiopeia
40.0% WR
VS
Zyra vs Cassiopeia matchup - 60.0% win rate
Zyra
60.0% WR

Who Wins the Cassiopeia vs Zyra Matchup?

Zyra wins the Cassiopeia vs Zyra matchup
Winner
Zyra
Matches: 5
40.0%
Win Rate
60.0%
7.5
CS / min
7.0
815
DMG / min
1,106
12,937
Gold / game
11,666
257
Heal / min
71
500
DMG Mitigated / min
302
1.3
CC / min
1.4
50.0%
Early Game WR
50.0%
33.3%
Late Game WR
66.7%

Cassiopeia vs Zyra Matchup Summary

The Cassiopeia vs Zyra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Zyra wins with a 60.0% win rate compared to Cassiopeia's 40.0%, giving Zyra a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Cassiopeia controls the early laning stage, but Zyra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Cassiopeia needs to press advantages before Zyra reaches their power spikes, while Zyra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Cassiopeia leads by 384 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra has a strong advantage in this matchup. Cassiopeia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zyra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Zyra Laning Phase Breakdown

Cassiopeia wins the laning phase against Zyra in League of Legends

Cassiopeia is favored during the laning phase against Zyra, winning 3 out of 5 key stat categories. Cassiopeia holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
7.5Cassiopeia
7.0Zyra
Cassiopeia edges out Zyra by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Cassiopeia.
Damage
815Cassiopeia
1,106Zyra
Zyra heavily out-damages Cassiopeia by 290 DMG/min, dominating both short trades and all-in fights. Cassiopeia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zyra's sustained damage advantage take over.
Economy
12,937Cassiopeia
11,666Zyra
Cassiopeia generates a commanding 1,271 more gold per game than Zyra. This substantial economic advantage means Cassiopeia consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zyra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.3Cassiopeia
1.4Zyra
Both Cassiopeia and Zyra provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
757Cassiopeia
373Zyra
Cassiopeia vastly out-sustains Zyra, healing and mitigating 384 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Zyra is forced to recall. Building grievous wounds early is essential for Zyra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Cassiopeia Build Against Zyra

The top-performing core items for Cassiopeia against Zyra are Rod of Ages, Liandry's Torment and Rylai's Crystal Scepter. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Zyra. This streamlined build focuses on the essentials for the Cassiopeia vs Zyra matchup, with room for situational adjustments based on team compositions and game state.

Early Game vs Late Game

Early Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia early game win rateCassiopeia50.0%
Zyra early game win rateZyra50.0%
Late Game
Zyra
66.7%
+33.3% advantage
Cassiopeia late game win rateCassiopeia33.3%
Zyra late game win rateZyra66.7%

The early game (first 15 minutes) is a toss-up between Cassiopeia and Zyra, with Cassiopeia holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Zyra is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Cassiopeia. Extended games heavily favor Zyra, whose kit and scaling make them a dominant force in team fights and objective control.

The power dynamics shift as the game progresses — Cassiopeia has the edge early, but Zyra gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Cassiopeia Runes Against Zyra

Precision rune tree - Cassiopeia primary runes vs ZyraPrecision
Conqueror - best Cassiopeia rune vs ZyraPresence of Mind - best Cassiopeia rune vs ZyraLegend: Haste - best Cassiopeia rune vs ZyraLast Stand - best Cassiopeia rune vs Zyra
Sorcery rune tree - Cassiopeia secondary runes vs ZyraSorcery
Manaflow Band - best Cassiopeia rune vs ZyraTranscendence - best Cassiopeia rune vs Zyra
100.0% WR

The Precision and Sorcery rune setup gives Cassiopeia the best tools to compete against Zyra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Cassiopeia matchup data for League of Legends patch 26.10. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
37.74%536.580210,35639.3%36.0%
51.06%476.583611,67068.4%39.3%
52.17%466.895111,24738.1%64.0%
48.78%416.774511,37063.2%36.4%
42.86%356.172811,85650.0%40.0%
48.57%356.480911,61143.8%52.6%
57.14%356.793511,51443.8%68.4%
44.12%346.675411,95372.7%30.4%
53.13%326.284611,76635.7%66.7%
61.29%316.278310,94533.3%79.0%
70.00%306.785613,08355.6%76.2%
57.14%286.587411,52037.5%83.3%
39.29%286.578411,99027.3%47.1%
53.57%286.71,05611,62835.7%71.4%
32.14%285.983011,23925.0%37.5%
52.00%255.977410,49470.0%40.0%
33.33%246.382110,98725.0%37.5%
66.67%246.578811,53740.0%85.7%
47.83%236.490812,71860.0%38.5%
47.83%237.072711,30150.0%45.5%
60.87%236.776610,85572.7%50.0%
36.36%226.394012,19922.2%46.1%
63.64%226.886711,81762.5%64.3%
40.00%206.383712,4180.0%57.1%
55.00%206.974912,05850.0%58.3%
65.00%206.492413,29683.3%57.1%
52.63%196.687211,60544.4%60.0%
47.37%195.87479,98740.0%55.6%
55.56%187.385912,27666.7%44.4%
44.44%186.567210,37250.0%37.5%
44.44%186.582513,10555.6%33.3%
58.82%176.880511,27755.6%62.5%
64.71%176.21,06114,66385.7%50.0%
33.33%156.698710,13527.3%50.0%
46.67%155.874010,92042.9%50.0%
40.00%155.41,03512,29020.0%50.0%
42.86%147.098312,28533.3%50.0%
35.71%146.570310,90228.6%42.9%
38.46%135.68078,06650.0%20.0%
30.77%136.989211,77540.0%25.0%
58.33%126.784411,22350.0%66.7%
50.00%126.572311,25833.3%66.7%
36.36%116.895312,41520.0%50.0%
45.45%116.775410,59966.7%20.0%
36.36%116.074612,8610.0%50.0%
36.36%116.680410,39150.0%20.0%
27.27%115.280910,75820.0%33.3%
45.45%116.61,01312,58540.0%50.0%
63.64%116.583313,98466.7%62.5%
54.55%116.775010,31171.4%25.0%
70.00%105.276011,62366.7%71.4%
30.00%106.887611,28933.3%28.6%
44.44%96.991212,72340.0%50.0%
66.67%96.096012,54250.0%71.4%
77.78%96.580515,25150.0%85.7%
55.56%95.863811,54275.0%40.0%
44.44%96.977312,56950.0%40.0%
44.44%96.593811,38250.0%40.0%
55.56%96.775311,24750.0%66.7%
12.50%86.796211,71933.3%0.0%
50.00%87.180510,71860.0%33.3%
50.00%86.386812,92375.0%25.0%
25.00%85.887112,36525.0%25.0%
50.00%87.11,04814,22150.0%50.0%
57.14%77.787810,17366.7%50.0%
28.57%77.491012,63133.3%25.0%
42.86%76.775211,1850.0%60.0%
57.14%76.889111,36466.7%0.0%
71.43%76.093313,880100.0%66.7%
42.86%76.79509,39650.0%33.3%
50.00%65.41,10610,45266.7%33.3%
33.33%65.997415,514100.0%20.0%
16.67%66.377712,0930.0%20.0%
66.67%66.46488,338100.0%33.3%
50.00%68.184511,17366.7%33.3%
66.67%66.41,10710,33350.0%75.0%
50.00%66.69079,68050.0%50.0%
33.33%64.772210,5630.0%40.0%
83.33%66.584911,806100.0%50.0%
33.33%65.081611,8920.0%40.0%
40.00%56.782711,93250.0%33.3%
20.00%57.05168,44350.0%0.0%
60.00%56.262910,9320.0%100.0%
40.00%58.178811,46066.7%0.0%
100.00%57.081013,115100.0%100.0%
60.00%57.51,11311,88966.7%50.0%
40.00%57.193713,62933.3%50.0%
40.00%57.581512,93750.0%33.3%
40.00%56.648410,55733.3%50.0%
40.00%56.770313,7890.0%50.0%
100.00%57.294613,607100.0%100.0%

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Cassiopeia vs Zyra - Frequently Asked Questions

How does Cassiopeia do against Zyra in League of Legends?

Zyra wins the Cassiopeia vs Zyra matchup with a 60.0% win rate compared to Cassiopeia's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Cassiopeia do against Zyra in the early game?

In the early game, Cassiopeia has the advantage against Zyra with a 50.0% win rate versus 50.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Zyra in the late game?

In the late game, Zyra takes over the Cassiopeia vs Zyra matchup with a 66.7% win rate compared to 33.3%. Zyra scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Zyra matchup?

Zyra wins the matchup against Cassiopeia with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Zyra is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Cassiopeia build against Zyra?

The best Cassiopeia build against Zyra includes Rod of Ages, Liandry's Torment, Rylai's Crystal Scepter. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Zyra?

The best Cassiopeia runes against Zyra use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Zyra matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Zyra?

No, Cassiopeia struggles against Zyra with only a 40.0% win rate. Zyra has the advantage in this matchup. Cassiopeia players should focus on safe farming and avoiding extended trades to minimize Zyra's lead.

How do I play Cassiopeia against Zyra?

When playing Cassiopeia against Zyra, play cautiously and avoid Zyra's power spikes. Look for jungle assistance and team-dependent plays since Zyra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.