- Win Rate
- 49.3%
- Pick Rate
- 2.6%
- Ban Rate
- 5.4%
Vayne ADC Runes: Keystone & Shards
- Patch
- 26.20
- Games
- 4,613
- Lane
- Bot
- Tier
- All Tiers
- Last Updated
- Oct 16, 2026 UTC
- Methodology
- Data Methodology
- Author
- Dakota Chinnick
Best Bot Vayne runes for LoL Patch 26.20 - Lethal Tempo from the Precision tree with Resolve secondary (49.1% WR, 48.7% pick rate). Vayne's optimal primary runes are Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace. Secondary tree: Conditioning, Overgrowth.
Primary Tree
Precision
Lethal TempoAttacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged]
TriumphTakedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.
'The most dangerous game brings the greatest glory.'
—Noxian Reckoner
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Coup de GraceDeal 8% more damage to champions who have less than 40% health.
ConditioningAfter 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 3%.
OvergrowthAbsorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.
When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.
Primary Tree
PrecisionLethal TempoAttacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged]
TriumphTakedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.
'The most dangerous game brings the greatest glory.'
—Noxian Reckoner
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Coup de GraceDeal 8% more damage to champions who have less than 40% health.
OvergrowthAbsorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.
When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.
ConditioningAfter 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 3%.
Every Vayne Bot Keystone and Secondary Tree (Patch 26.20)
4,456 gamesVayne Bot runs Lethal Tempo in 69% of games, with a 49.3% win rate. Resolve is the usual secondary tree (69%). Standard stat shards: Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense).
Keystones
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Lethal TempoMost played | 68.8% | 49.3% | 3,066 |
 Press the Attack | 27.5% | 48.9% | 1,224 |
 Fleet Footwork | 1.2% | 52.7% | 55 |
Secondary trees
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 ResolveMost played | 69.3% | 49.6% | 3,088 |
 Domination | 21.7% | 49.1% | 969 |
 Inspiration | 4.4% | 48.5% | 196 |
 Sorcery | 3.5% | 40.0% | 155 |
| Precision | 1.1% | 64.6% | 48 |
Pick rate is the share of Vayne games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.
Vayne Minor Runes by Tree
Every minor rune Vayne players take, grouped by rune tree, with how often it is picked and how often it wins.
Precision
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| TriumphMost played | 92.9% | 49.3% | 4,139 |
| Legend: Alacrity | 90.7% | 49.3% | 4,042 |
| Coup de Grace | 86.1% | 49.3% | 3,835 |
 Cut Down | 10.5% | 50.3% | 469 |
 Legend: Bloodline | 7.3% | 49.2% | 327 |
 Presence of Mind | 4.3% | 51.1% | 190 |
Resolve
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| OvergrowthMost played | 67.3% | 49.8% | 2,997 |
| Conditioning | 65.4% | 49.6% | 2,914 |
 Bone Plating | 2.6% | 50.4% | 117 |
 Second Wind | 1.1% | 50.0% | 50 |
 Unflinching | 1.1% | 51.1% | 47 |
Domination
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Treasure HunterMost played | 15.6% | 48.3% | 695 |
 Taste of Blood | 13.2% | 48.2% | 589 |
 Sudden Impact | 9.6% | 51.4% | 428 |
 Ultimate Hunter | 6.4% | 52.6% | 287 |
 Relentless Hunter | 1.2% | 48.1% | 54 |
 Grisly Mementos | 1.1% | 55.1% | 49 |
Inspiration
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Cash BackMost played | 3.0% | 47.0% | 132 |
 Triple Tonic | 2.2% | 54.6% | 97 |
 Cosmic Insight | 1.3% | 47.5% | 59 |
 Magical Footwear | 0.9% | 47.6% | 42 |
Sorcery
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 CelerityMost played | 2.2% | 45.5% | 99 |
 Gathering Storm | 2.2% | 38.8% | 98 |
 Nimbus Cloak | 1.4% | 46.8% | 62 |
 Absolute Focus | 1.1% | 42.9% | 49 |
Vayne Stat Shards
Which stat shards Vayne players choose in each of the three shard rows, and the win rate of each.
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Adaptive Force (flex)Most played | 97.1% | 49.4% | 4,329 |
 Attack Speed (offense) | 96.4% | 49.2% | 4,297 |
 Health Scaling (defense) | 84.3% | 49.0% | 3,757 |
| Health (defense) | 11.7% | 51.7% | 520 |
 Tenacity and Slow Resist (defense) | 4.0% | 48.0% | 179 |
| Adaptive Force (offense) | 3.4% | 51.3% | 150 |
 Move Speed (flex) | 2.3% | 43.3% | 104 |
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Vayne Runes FAQ - Patch 26.20
What is the best keystone for Vayne Bot?
Lethal Tempo: Vayne Bot takes it in 69% of ranked games and wins 49.3% of 3,066 games. Alternatives: Press the Attack (27%, 48.9%), Fleet Footwork (1%, 52.7%).
What stat shards should Vayne take?
Most Vayne players take Attack Speed (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.
What are the best Vayne runes in patch 26.20?
The best Vayne runes in patch 26.20 use the Precision tree with Lethal Tempo, Triumph, Legend: Alacrity, and Coup de Grace, and the Resolve tree with Conditioning and Overgrowth. This rune setup achieves a 49.1% win rate with a 48.7% pick rate.
What is the win rate for Vayne's best rune page?
Vayne's best rune page has a 49.1% win rate in patch 26.20, which is -0.1% compared to Vayne's average win rate. This rune setup has a 48.7% pick rate among Vayne players.
What keystone should I use on Vayne?
Lethal Tempo from the Precision tree is the best keystone rune for Vayne in patch 26.20. This keystone synergizes well with Vayne's kit and provides a 49.1% win rate.
What is Vayne's primary rune tree?
Vayne's primary rune tree is Precision. The optimal Precision runes for Vayne are Lethal Tempo, Triumph, Legend: Alacrity, and Coup de Grace, with Lethal Tempo being the keystone of choice.
What is Vayne's secondary rune tree?
Vayne's best secondary rune tree is Resolve. The recommended Resolve runes are Conditioning and Overgrowth, which complement Vayne's Precision primary tree.
What are alternative rune setups for Vayne?
An alternative Vayne rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Vayne's runes?
Vayne's top rune page has a 48.7% pick rate in patch 26.20. This indicates that 48.7% of Vayne players use the Lethal Tempo setup with Precision and Resolve trees.