Enlightenment•Skill

Is Enlightenment good in Slay the Spire 2?

Enlightenment is an event Event skill in Slay the Spire 2. In combat it resolves as: Reduce the cost of ALL cards in your Hand to 1 this turn. It currently underperforms most alternatives, sitting at F tier in our Slay the Spire 2 card rankings.

Across 42 recorded runs, decks running it win 20.0% of the time, comfortably clear of the 18.9% average, by 1.1%. It’s a more selective pick, turning up in just 1.1% of decks that could run it. Silent players keep it in 0.6% of their runs, so it’s a familiar sight in those decks. On average it shows up 2.0 times in the decks that take it.

It performs best next to Infinite Blades — together they post a +18.5% swing in win rate. It also has strong chemistry with the relic Anchor, which moves its win rate by +24.4%. At 0 energy, it’s upgraded in 17.4% of runs and usually joins the deck around floor 22.

That’s 8 wins, 32 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 16.7% of its appearances. Read on for Enlightenment’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Event run.

Best Cards to Pair with Enlightenment

Ranked by win-rate lift, Enlightenment performs best alongside Infinite Blades (+18.5%), Strike (+11.3%), and Defend (+11.3%).

Infinite Blades+18.5%3 runsStrike+11.3%6 runsDefend+11.3%6 runsNeutralize+11.3%6 runsSurvivor+11.3%6 runsBlade Dance+10.8%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Enlightenment Win Rate by Class

Enlightenment is played across 5 classes, led by Silent (50.0%), Necrobinder (21.4%), and Regent (14.3%) by win rate.

The Silent50.0%6 runsThe Necrobinder21.4%14 runsThe Regent14.3%7 runsThe Ironclad11.1%10 runsThe Defect0.0%5 runs

Best Relics for Enlightenment

Enlightenment pairs best with the relics Anchor (+24.4%), Bronze Scales (+22.9%), and Pocketwatch (+18.5%), ranked by win-rate lift.

Anchor+24.4%8 runsBronze Scales+22.9%4 runsPocketwatch+18.5%3 runsWar Hammer+18.5%3 runsNunchaku+17.5%6 runsBag of Preparation+16.8%9 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Enlightenment Card Details

Enlightenment is an event skill costing 0 energy; it’s upgraded in 17.4% of runs and usually picked up by floor 22.

Reduce the cost of ALL cards in your Hand to 1 this turn.

What Ends Runs with Enlightenment

Enlightenment’s most common run-enders are Knowledge Demon Boss (16.7%), The Insatiable Boss (11.9%), and Infested Prisms Elite (9.5%).

• Knowledge Demon Boss16.7% of runs
• The Insatiable Boss11.9% of runs
• Infested Prisms Elite9.5% of runs
• Decimillipede Elite7.1% of runs

See Also

Compare Enlightenment with the rest of the best Slay the Spire 2 cards, relics, and classes below.