Enlightenment Skill

Is Enlightenment good in Slay the Spire 2?

Enlightenment is an event Event skill in Slay the Spire 2. In combat it resolves as: Reduce the cost of ALL cards in your Hand to 1 this turn. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 286 recorded runs, decks running it win 17.6% of the time, comfortably clear of the 14.3% average, by 3.3%. It’s a more selective pick, turning up in just 1.1% of decks that could run it. Silent players keep it in 1.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 2.1 times in the decks that take it.

It performs best next to Serpent Form — together they post a +21.4% swing in win rate. It also has strong chemistry with the relic Fragrant Mushroom, which moves its win rate by +23.8%. At 0 energy, it’s upgraded in 17.1% of runs and usually joins the deck around floor 23.

That’s 50 wins, 234 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 10.1% of its appearances. Read on for Enlightenment’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Event run.

When to Pick Up Enlightenment

Enlightenment is strongest when it joins the deck in Act 2, where runs win 17.6% across 286 runs — one of 1 recorded pickup windows.

Win rate of runs by the act Enlightenment entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Enlightenment

Ranked by win-rate lift, Enlightenment performs best alongside Serpent Form (+21.4%), Prepared (+21.1%), and Mad Science (+19.9%).

Serpent Form+21.4%15 runsPrepared+21.1%23 runsMad Science+19.9%16 runsBlur+17.4%15 runsFootwork+16.1%16 runsPiercing Wail+13.9%21 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Enlightenment Win Rate by Class

Enlightenment is played across 5 classes, led by Silent (29.3%), Necrobinder (16.0%), and Ironclad (15.2%) by win rate.

The Silent29.3%58 runsThe Necrobinder16.0%50 runsThe Ironclad15.2%80 runsThe Regent12.2%49 runsThe Defect10.9%47 runs

Best Relics for Enlightenment

Enlightenment pairs best with the relics Fragrant Mushroom (+23.8%), Anchor (+22.7%), and Mercury Hourglass (+21.1%), ranked by win-rate lift.

Fragrant Mushroom+23.8%16 runsAnchor+22.7%44 runsMercury Hourglass+21.1%24 runsParrying Shield+17.7%30 runsWar Paint+17.6%49 runsLizard Tail+17.4%15 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Enlightenment Card Details

Enlightenment is an event skill costing 0 energy; it’s upgraded in 17.1% of runs and usually picked up by floor 23.

Reduce the cost of ALL cards in your Hand to 1 this turn.

What Ends Runs with Enlightenment

Enlightenment’s most common run-enders are Knowledge Demon Boss (10.1%), Kaiser Crab Boss (10.1%), and Decimillipede Elite (7.7%).

• Knowledge Demon Boss10.1% of runs
• Kaiser Crab Boss10.1% of runs
• Decimillipede Elite7.7% of runs
• The Insatiable Boss7.0% of runs
• Queen Boss6.6% of runs

See Also

Compare Enlightenment with the rest of the best Slay the Spire 2 cards, relics, and classes below.