Pandora's Box Relic

Is Pandora's Box good in Slay the Spire 2?

Pandora's Box is an ancient relic in Slay the Spire 2. While carried, it does the following: Transform ALL Strikes and Defends. It currently underperforms most relics, sitting at D tier in our Slay the Spire 2 relic rankings.

Across 180 recorded runs, decks carrying it win 33.3% of the time, comfortably clear of the 13.8% average, by 19.5%. It’s a more situational relic, showing up in just 0.9% of runs. The class that gets the most out of it is the Regent, at a 44.8% win rate. Regent players hold onto it in 0.9% of their runs.

It combos especially well with Footwork, worth a +26.7% win-rate swing together. Another strong card to run with it is Deflect, worth +23.2% to its win rate. On average it’s acquired around floor 20 of a run. Its ancient rarity shapes how frequently you’ll run into it.

It has 60 run wins against 120 losses in our tracked data. When runs carrying it end, the most frequent culprit is Test Subject Boss, which closes out 8.3% of them. Read on for Pandora's Box’s complete card, class, and threat breakdown before you decide to pick it up.

Pick or Skip: Pandora's Box

Pandora's Box is taken in 100.0% of its 180 recorded offers, but with 180 runs picking it and 0 passing, neither side has enough decided runs for a win rate yet.

Taken 180 times out of 180 offers.

A win rate is only shown once that side clears the sample floor. Below it you get the run counts and nothing else — a 0% here would be a reporting artefact, not a result.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Pandora's Box

Ranked by win-rate lift, the best cards to run with Pandora's Box are Footwork (+26.7%), Deflect (+23.2%), and Fan of Knives (+20.0%).

Footwork+26.7%20 runsDeflect+23.2%23 runsFan of Knives+20.0%15 runsMolten Fist+19.6%17 runsHidden Cache+19.6%17 runsMad Science+18.7%25 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Pandora's Box Win Rate by Class

Pandora's Box shows up across 5 classes, led by Regent (44.8%), Silent (38.3%), and Ironclad (35.5%) by win rate.

The Regent44.8%29 runsThe Silent38.3%47 runsThe Ironclad35.5%31 runsThe Necrobinder26.7%30 runsThe Defect23.3%43 runs

Pandora's Box Details

Pandora's Box is an ancient relic carried in 0.9% of runs and usually picked up around floor 20.

Transform ALL Strikes and Defends.

What Ends Runs with Pandora's Box

Pandora's Box’s most common run-enders are Test Subject Boss (8.3%), Queen Boss (7.8%), and Aeonglass Boss (7.2%).

• Test Subject Boss8.3% of runs
• Queen Boss7.8% of runs
• Aeonglass Boss7.2% of runs
• Knowledge Demon Boss5.6% of runs
• The Insatiable Boss5.6% of runs

See Also

Compare Pandora's Box with the rest of the best Slay the Spire 2 relics, cards, and classes below.