Pandora's BoxRelic
Transform ALL Strikes and Defends.
Is Pandora's Box good in Slay the Spire 2?
Pandora's Box is an ancient relic in Slay the Spire 2. While carried, it does the following: Transform ALL Strikes and Defends. It’s a reliable mid-tier relic, landing at C tier in our rankings.
Across 25 recorded runs, decks carrying it win 41.7% of the time, comfortably clear of the 19.0% average, by 22.7%. It’s a more situational relic, showing up in just 0.7% of runs. The class that gets the most out of it is the Regent, at a 75.0% win rate. Regent players hold onto it in 0.6% of their runs.
It combos especially well with Pillar of Creation, worth a +58.3% win-rate swing together. Another strong card to run with it is Double Energy, worth +58.3% to its win rate. On average it’s acquired around floor 20 of a run. Its ancient rarity shapes how frequently you’ll run into it.
It has 10 run wins against 14 losses in our tracked data. When runs carrying it end, the most frequent culprit is Test Subject Boss, which closes out 12.0% of them. Read on for Pandora's Box’s complete card, class, and threat breakdown before you decide to pick it up.
Pandora's Box Win Rate & Pick Rate
Pandora's Box’s 41.7% win rate clears the 19.0% all-run average by 22.7%, the gap charted below.
Run Outcomes with Pandora's Box
Pandora's Box has 10 wins and 15 losses over 25 tracked runs (40.0% won); abandoned runs count as losses.
- Wins 40.0%
- Losses 60.0%
Best Cards with Pandora's Box
Ranked by win-rate lift, the best cards to run with Pandora's Box are Pillar of Creation (+58.3%), Double Energy (+58.3%), and Focused Strike (+58.3%).
Pillar of Creation3 runs
Double Energy3 runs
Focused Strike3 runs
Boost Away4 runs
Overclock4 runs
Falling Star4 runsBased on small co-occurring samples — treat these as early signals, not final verdicts.
Pandora's Box Details
Pandora's Box is an ancient relic carried in 0.7% of runs and usually picked up around floor 20.
Transform ALL Strikes and Defends.
What Ends Runs with Pandora's Box
Pandora's Box’s most common run-enders are Test Subject Boss (12.0%), Knowledge Demon Boss (8.0%), and Doormaker Boss (8.0%).
- Test Subject Boss12.0% of runs
- Knowledge Demon Boss8.0% of runs
- Doormaker Boss8.0% of runs
Get the Winning Edge
Real-time overlays, automatic match tracking, and exclusive tools — everything you need to climb, free on your PC.
- In-game overlays
- Automatic match tracking
- Desktop-exclusive tools
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Pandora's Box – Frequently Asked Questions
Is Pandora's Box good in Slay the Spire 2?
Across 25 tracked runs carrying it, Pandora's Box wins 41.7% of the time — +22.7% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Pandora's Box do in Slay the Spire 2?
Transform ALL Strikes and Defends.
How rare is Pandora's Box in Slay the Spire 2?
Pandora's Box is an Ancient relic, picked up in 0.7% of tracked runs.
What is the best card to use with Pandora's Box?
In tracked runs, Pandora's Box has performed best alongside Pillar of Creation, which lifts its win rate by +58.3% over 3 runs together.
Which class is Pandora's Box best in?
Pandora's Box has its highest win rate with The Regent (75.0%).
See Also
Compare Pandora's Box with the rest of the best Slay the Spire 2 relics, cards, and classes below.