Lissandra - League of Legends Champion
Win Rate
49.1%
Pick Rate
1.1%

LissandraRunes

DMage
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 12, 2026
MethodologyData Methodology

Best Lissandra runes for LoL Patch 26.5 - Arcane Comet from the Sorcery tree with Domination secondary (52.5% WR, 15.5% pick rate). Lissandra's optimal primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Secondary tree: Cheap Shot, Ultimate Hunter.

Lissandra performs best with Arcane Comet as the keystone rune from the Sorcery tree. Lissandra's optimal primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Lissandra's secondary rune tree is Domination with Cheap Shot, Ultimate Hunter. This rune setup achieves a 52.53% win rate (+3.4% win rate difference) with a 15.5% pick rate across 158 Lissandra games.
52.5%Win Rate
+3.4%WR Diff
15.5%Pick Rate
Arcane CometArcane Comet

Damaging a champion with an ability hurls a comet at their location, or, if Arcane Comet is on cooldown, reduces its remaining cooldown.

Adaptive Damage: 30 - 130 based on level (+0.05 AP and +0.1 bonus AD)
Cooldown: 20 - 8s

Cooldown Reduction:
Single Target: 20%.
Area of Effect: 10%.
Damage over Time: 5%.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

ScorchScorch

Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.

Cooldown: 10s

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

This alternative Lissandra rune build uses Electrocute as the keystone from the Domination tree. The primary runes are Electrocute, Cheap Shot, Grisly Mementos, Ultimate Hunter. Lissandra's secondary rune tree is Sorcery with Manaflow Band, Transcendence. This setup achieves a 49.00% win rate (-0.1% win rate difference) with a 34.5% pick rate across 351 games.
49.0%Win Rate
-0.1%WR Diff
34.5%Pick Rate
ElectrocuteElectrocute

Hitting a champion with 3 separate attacks or abilities within 3s deals bonus adaptive damage.

Damage: 70 - 240 (+0.1 bonus AD, +0.05 AP) damage.
Cooldown: 20s

'We called them the Thunderlords, for to speak of their lightning was to invite disaster.'

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

These champions share at least 4 runes with Lissandra's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Lissandra's playstyle or want to learn champions with familiar rune setups.Maokai, Neeko, Zyra, Lux, Viktor and 5 others

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Lissandra Runes - Frequently Asked Questions

What are the best Lissandra runes in patch 26.5?

The best Lissandra runes in patch 26.5 use the Sorcery tree with Arcane Comet, Manaflow Band, Transcendence, and Scorch, and the Domination tree with Cheap Shot and Ultimate Hunter. This rune setup achieves a 52.5% win rate with a 15.5% pick rate.

What is the win rate for Lissandra's best rune page?

Lissandra's best rune page has a 52.5% win rate in patch 26.5, which is +3.4% compared to Lissandra's average win rate. This rune setup has a 15.5% pick rate among Lissandra players.

What keystone should I use on Lissandra?

Arcane Comet from the Sorcery tree is the best keystone rune for Lissandra in patch 26.5. This keystone synergizes well with Lissandra's kit and provides a 52.5% win rate.

What is Lissandra's primary rune tree?

Lissandra's primary rune tree is Sorcery. The optimal Sorcery runes for Lissandra are Arcane Comet, Manaflow Band, Transcendence, and Scorch, with Arcane Comet being the keystone of choice.

What is Lissandra's secondary rune tree?

Lissandra's best secondary rune tree is Domination. The recommended Domination runes are Cheap Shot and Ultimate Hunter, which complement Lissandra's Sorcery primary tree.

What are alternative rune setups for Lissandra?

An alternative Lissandra rune setup uses Electrocute from the Domination tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Lissandra's runes?

Lissandra's top rune page has a 15.5% pick rate in patch 26.5. This indicates that 15.5% of Lissandra players use the Arcane Comet setup with Sorcery and Domination trees.