First Strike Best Builds - LoL Rune 2026

Overview Builds

Discover the 5 champions that use First Strike in their primary rune builds. The top performing builds include Kha'Zix (68.42% rune WR, +20.33% diff), Gwen (66.67% rune WR, +18.37% diff), Kassadin (80.00% rune WR, +30.40% diff). The "Rune WR Diff" column shows how much better or worse the rune build performs compared to the champion's overall win rate - positive values indicate the rune synergizes well with that champion.

Rank	Champion	Rune WR	Rune WR Diff	Rune PR
1	Kha'Zix	68.42%	+20.33%	0.54%
2	Gwen	66.67%	+18.37%	0.50%
3	Kassadin	80.00%	+30.40%	1.01%
4	Qiyana	60.87%	+15.27%	0.82%
5	Syndra	66.67%	+16.39%	0.34%
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First Strike Builds - Frequently Asked Questions

What are the best First Strike builds in Patch 26.13?

The highest win rate First Strike builds are Kha'Zix (68.42% WR), Gwen (66.67% WR), Kassadin (80.00% WR). These builds have been tested across 5 champions in ranked play.

How do I build First Strike on my champion?

First Strike is typically used as part of a Inspiration build. The most successful First Strike builds pair it with Triple Tonic, Cash Back, Sudden Impact. Check the builds table above to find the optimal rune page for your specific champion.

How many champions can use First Strike effectively?

Currently, 5 champions use First Strike in their optimal builds. The rune is most popular among Assassin champions (50% of users).Syndra achieves the highest win rate at 50.27%.

What is the average win rate for First Strike builds?

First Strike builds average a 51.05% win rate across all champions. Top performers like Kha'Zix and Gwen exceed this with win rates of 68.42% and 66.67% respectively.