Lissandravs Vayne
Lissandra vs Vayne is a decisive matchup in LoL patch 26.10. Lissandra wins with a 80.0% win rate (+60.0%) over Vayne based on 5 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Vayne matchup.
Lissandra Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(80.0%)Who Wins the Lissandra vs Vayne Matchup?
Lissandra vs Vayne Matchup Summary
The Lissandra vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Lissandra wins with a 80.0% win rate compared to Vayne's 20.0%, giving Lissandra a 60.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Lissandra leads by 0.6s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Lissandra vs Vayne Laning Phase Breakdown
Vayne is favored during the laning phase against Lissandra, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.
Best Lissandra Build Against Vayne
Sorcerer's Shoes is the optimal boots choice against Vayne, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Vayne are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Vayne matchup.
Early Game vs Late Game
Lissandra75.0%Vayne25.0%Lissandra100.0%Vayne0.0%Lissandra dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Vayne. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Lissandra is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.
Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Lissandra Runes Against Vayne
Sorcery
Precision
Running Sorcery primary with Precision secondary allows Lissandra to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 52.05% | 171 | 6.6 | 769 | 11,311 | 51.3% | 52.8% | |
| 56.96% | 158 | 6.8 | 838 | 12,109 | 62.9% | 53.1% | |
| 56.25% | 144 | 6.8 | 802 | 12,075 | 60.0% | 53.9% | |
| 57.35% | 136 | 6.5 | 851 | 11,777 | 43.3% | 68.4% | |
| 54.17% | 120 | 6.6 | 894 | 11,838 | 58.7% | 51.4% | |
| 52.10% | 119 | 6.6 | 759 | 11,544 | 58.0% | 47.8% | |
| 50.55% | 91 | 6.8 | 864 | 11,833 | 42.9% | 55.4% | |
| 50.00% | 86 | 6.0 | 763 | 11,363 | 48.6% | 51.0% | |
| 49.40% | 83 | 6.6 | 682 | 10,756 | 35.1% | 60.9% | |
| 53.09% | 81 | 6.8 | 945 | 12,084 | 59.5% | 47.7% | |
| 48.65% | 74 | 6.5 | 870 | 12,075 | 65.5% | 37.8% | |
| 44.44% | 72 | 6.4 | 800 | 11,902 | 48.0% | 42.5% | |
| 40.30% | 67 | 6.6 | 791 | 12,260 | 54.2% | 32.6% | |
| 41.07% | 56 | 7.0 | 910 | 10,564 | 42.9% | 39.3% | |
| 43.75% | 48 | 6.4 | 926 | 11,684 | 42.9% | 44.4% | |
| 45.83% | 48 | 6.9 | 764 | 10,316 | 48.1% | 42.9% | |
| 44.68% | 47 | 7.1 | 913 | 10,274 | 46.1% | 42.9% | |
| 48.89% | 45 | 6.7 | 741 | 11,850 | 55.6% | 44.4% | |
| 56.82% | 44 | 6.6 | 807 | 10,714 | 60.0% | 52.6% | |
| 47.50% | 40 | 6.8 | 889 | 11,814 | 35.7% | 53.9% | |
| 52.50% | 40 | 6.5 | 801 | 11,078 | 59.1% | 44.4% | |
| 48.72% | 39 | 6.3 | 794 | 10,537 | 57.9% | 40.0% | |
| 54.05% | 37 | 6.2 | 894 | 11,678 | 47.1% | 60.0% | |
| 48.65% | 37 | 6.8 | 842 | 12,048 | 69.2% | 37.5% | |
| 52.78% | 36 | 6.5 | 779 | 12,442 | 60.0% | 50.0% | |
| 50.00% | 34 | 6.6 | 773 | 9,954 | 60.0% | 42.1% | |
| 50.00% | 34 | 6.7 | 899 | 12,478 | 50.0% | 50.0% | |
| 59.38% | 32 | 6.6 | 851 | 12,140 | 46.1% | 68.4% | |
| 43.75% | 32 | 6.3 | 735 | 11,211 | 55.6% | 39.1% | |
| 62.50% | 32 | 7.0 | 892 | 11,236 | 66.7% | 58.8% | |
| 35.48% | 31 | 6.7 | 901 | 11,727 | 50.0% | 28.6% | |
| 33.33% | 30 | 5.8 | 919 | 12,367 | 50.0% | 25.0% | |
| 36.67% | 30 | 6.9 | 881 | 12,313 | 50.0% | 31.8% | |
| 51.72% | 29 | 6.8 | 817 | 10,569 | 62.5% | 38.5% | |
| 51.72% | 29 | 6.9 | 792 | 11,756 | 70.0% | 42.1% | |
| 53.85% | 26 | 6.2 | 791 | 11,442 | 55.6% | 52.9% | |
| 61.54% | 26 | 6.8 | 816 | 11,316 | 71.4% | 50.0% | |
| 50.00% | 22 | 6.8 | 842 | 11,410 | 60.0% | 41.7% | |
| 45.45% | 22 | 7.1 | 847 | 10,225 | 53.9% | 33.3% | |
| 61.90% | 21 | 5.8 | 852 | 10,292 | 58.3% | 66.7% | |
| 55.00% | 20 | 5.7 | 805 | 10,447 | 66.7% | 45.5% | |
| 35.00% | 20 | 6.5 | 672 | 11,293 | 44.4% | 27.3% | |
| 26.32% | 19 | 5.9 | 711 | 12,064 | 25.0% | 27.3% | |
| 41.18% | 17 | 6.9 | 765 | 10,637 | 60.0% | 14.3% | |
| 70.59% | 17 | 6.5 | 897 | 12,690 | 80.0% | 66.7% | |
| 43.75% | 16 | 3.5 | 593 | 10,753 | 50.0% | 41.7% | |
| 66.67% | 15 | 7.0 | 929 | 11,709 | 40.0% | 80.0% | |
| 53.33% | 15 | 6.7 | 832 | 11,821 | 50.0% | 57.1% | |
| 66.67% | 15 | 6.6 | 769 | 10,958 | 57.1% | 75.0% | |
| 60.00% | 15 | 6.8 | 889 | 14,333 | 100.0% | 50.0% | |
| 66.67% | 15 | 7.4 | 904 | 12,423 | 85.7% | 50.0% | |
| 42.86% | 14 | 3.8 | 852 | 13,758 | 66.7% | 36.4% | |
| 38.46% | 13 | 6.3 | 844 | 13,803 | 50.0% | 36.4% | |
| 69.23% | 13 | 5.9 | 778 | 12,797 | 100.0% | 60.0% | |
| 66.67% | 12 | 6.7 | 860 | 11,779 | 66.7% | 66.7% | |
| 41.67% | 12 | 6.8 | 885 | 12,735 | 25.0% | 50.0% | |
| 72.73% | 11 | 7.4 | 869 | 11,820 | 80.0% | 66.7% | |
| 36.36% | 11 | 6.3 | 997 | 12,018 | 33.3% | 40.0% | |
| 50.00% | 10 | 6.8 | 743 | 11,790 | 66.7% | 25.0% | |
| 22.22% | 9 | 1.5 | 486 | 8,395 | 0.0% | 33.3% | |
| 33.33% | 9 | 6.7 | 739 | 11,320 | 100.0% | 14.3% | |
| 33.33% | 9 | 7.5 | 770 | 10,762 | 66.7% | 16.7% | |
| 55.56% | 9 | 6.9 | 1,078 | 11,746 | 33.3% | 66.7% | |
| 22.22% | 9 | 7.0 | 825 | 11,613 | 20.0% | 25.0% | |
| 66.67% | 9 | 6.1 | 896 | 12,851 | 66.7% | 66.7% | |
| 22.22% | 9 | 5.7 | 760 | 10,708 | 50.0% | 14.3% | |
| 37.50% | 8 | 2.0 | 556 | 7,339 | 50.0% | 0.0% | |
| 37.50% | 8 | 7.5 | 946 | 13,491 | 66.7% | 20.0% | |
| 37.50% | 8 | 7.3 | 917 | 10,195 | 20.0% | 66.7% | |
| 50.00% | 8 | 2.7 | 513 | 9,630 | 100.0% | 33.3% | |
| 50.00% | 8 | 7.3 | 1,053 | 11,457 | 50.0% | 50.0% | |
| 25.00% | 8 | 6.8 | 828 | 11,863 | 33.3% | 20.0% | |
| 57.14% | 7 | 2.4 | 623 | 12,288 | 0.0% | 57.1% | |
| 85.71% | 7 | 6.4 | 998 | 11,349 | 100.0% | 75.0% | |
| 28.57% | 7 | 5.2 | 722 | 10,611 | 100.0% | 16.7% | |
| 71.43% | 7 | 7.0 | 942 | 11,670 | 33.3% | 100.0% | |
| 57.14% | 7 | 6.5 | 707 | 7,453 | 75.0% | 33.3% | |
| 28.57% | 7 | 7.0 | 1,200 | 12,848 | 50.0% | 20.0% | |
| 83.33% | 6 | 6.9 | 932 | 11,049 | 75.0% | 100.0% | |
| 83.33% | 6 | 7.6 | 1,024 | 12,158 | 100.0% | 66.7% | |
| 50.00% | 6 | 6.7 | 855 | 13,791 | 100.0% | 40.0% | |
| 33.33% | 6 | 7.0 | 941 | 12,154 | 50.0% | 25.0% | |
| 16.67% | 6 | 6.3 | 994 | 10,568 | 50.0% | 0.0% | |
| 33.33% | 6 | 6.2 | 783 | 10,968 | 50.0% | 25.0% | |
| 66.67% | 6 | 4.3 | 677 | 11,772 | 50.0% | 75.0% | |
| 40.00% | 5 | 2.0 | 510 | 8,119 | 66.7% | 0.0% | |
| 80.00% | 5 | 5.3 | 906 | 10,607 | 100.0% | 50.0% | |
| 40.00% | 5 | 4.3 | 675 | 11,128 | 50.0% | 33.3% | |
| 60.00% | 5 | 6.2 | 812 | 7,814 | 60.0% | 0.0% | |
| 20.00% | 5 | 1.8 | 564 | 8,399 | 50.0% | 0.0% | |
| 80.00% | 5 | 6.8 | 646 | 7,528 | 75.0% | 100.0% | |
| 60.00% | 5 | 7.4 | 634 | 11,653 | 100.0% | 50.0% | |
| 60.00% | 5 | 2.4 | 620 | 7,499 | 33.3% | 100.0% | |
| 60.00% | 5 | 3.7 | 785 | 8,706 | 50.0% | 66.7% | |
| 0.00% | 5 | 6.6 | 750 | 11,439 | 0.0% | 0.0% | |
| 60.00% | 5 | 5.8 | 789 | 11,402 | 50.0% | 66.7% | |
| 60.00% | 5 | 3.8 | 417 | 3,796 | 60.0% | 0.0% | |
| 40.00% | 5 | 6.3 | 771 | 7,039 | 0.0% | 100.0% | |
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Lissandra vs Vayne - Frequently Asked Questions
How does Lissandra do against Vayne in League of Legends?
Lissandra wins the Lissandra vs Vayne matchup with a 80.0% win rate compared to Vayne's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.
How does Lissandra do against Vayne in the early game?
In the early game, Lissandra has the advantage against Vayne with a 75.0% win rate versus 25.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Lissandra do against Vayne in the late game?
In the late game, Lissandra takes over the Lissandra vs Vayne matchup with a 100.0% win rate compared to 0.0%. Lissandra scales better into team fights and objective contests after 25 minutes.
Who wins the Lissandra vs Vayne matchup?
Lissandra wins the matchup against Vayne with a 80.0% win rate in League of Legends patch 26.10. The 60.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 5 games analyzed.
What is the best Lissandra build against Vayne?
The best Lissandra build against Vayne includes Shadowflame, Zhonya's Hourglass, Malignance with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Lissandra runes against Vayne?
The best Lissandra runes against Vayne use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Lissandra counter Vayne?
Yes, Lissandra has a favorable matchup against Vayne with a 80.0% win rate. Lissandra strongly counters Vayne in lane based on current patch 26.10 data.
How do I play Lissandra against Vayne?
When playing Lissandra against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.