Vaynevs Lissandra
Vayne vs Lissandra is a decisive matchup in LoL patch 26.10. Lissandra wins with a 80.0% win rate (+60.0%) over Vayne based on 5 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Lissandra matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Lissandra(20.0%)Who Wins the Vayne vs Lissandra Matchup?
Vayne vs Lissandra Matchup Summary
The Vayne vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Lissandra wins with a 80.0% win rate compared to Vayne's 20.0%, giving Lissandra a 60.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Lissandra leads by 0.6s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Lissandra Laning Phase Breakdown
Vayne is favored during the laning phase against Lissandra, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.
Best Vayne Build Against Lissandra
Berserker's Greaves is the optimal boots choice against Lissandra, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Lissandra are Jak'Sho, The Protean, Terminus and Blade of The Ruined King. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Lissandra matchup.
Early Game vs Late Game
Vayne25.0%Lissandra75.0%Vayne0.0%Lissandra100.0%Lissandra dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Vayne. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Lissandra is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.
Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Vayne Runes Against Lissandra
Precision
Resolve
The Precision and Resolve rune setup gives Vayne the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 43.14% | 707 | 6.1 | 874 | 13,418 | 43.8% | 42.7% | |
| 47.63% | 527 | 6.0 | 792 | 12,800 | 44.5% | 50.0% | |
| 45.36% | 496 | 6.0 | 822 | 12,847 | 42.7% | 47.6% | |
| 53.88% | 425 | 6.1 | 840 | 13,295 | 53.3% | 54.3% | |
| 51.72% | 408 | 5.9 | 790 | 12,832 | 47.9% | 54.4% | |
| 49.87% | 389 | 5.7 | 771 | 12,129 | 47.0% | 52.4% | |
| 49.49% | 295 | 6.3 | 844 | 12,877 | 46.4% | 52.2% | |
| 51.22% | 246 | 6.3 | 895 | 13,238 | 47.4% | 54.6% | |
| 53.48% | 187 | 6.1 | 886 | 12,895 | 51.1% | 55.6% | |
| 52.44% | 164 | 6.0 | 837 | 12,570 | 46.7% | 57.3% | |
| 43.48% | 161 | 5.8 | 775 | 13,152 | 45.5% | 42.1% | |
| 47.97% | 148 | 6.0 | 833 | 13,581 | 47.3% | 48.4% | |
| 44.12% | 136 | 5.9 | 794 | 12,607 | 42.1% | 45.6% | |
| 49.62% | 131 | 5.9 | 839 | 13,138 | 50.0% | 49.3% | |
| 52.31% | 130 | 6.5 | 958 | 12,005 | 51.7% | 52.8% | |
| 50.39% | 129 | 6.6 | 862 | 13,605 | 43.4% | 55.3% | |
| 45.31% | 128 | 6.2 | 755 | 12,553 | 48.3% | 42.6% | |
| 41.73% | 127 | 5.8 | 628 | 10,793 | 35.6% | 47.1% | |
| 58.82% | 119 | 6.3 | 877 | 11,438 | 48.2% | 68.3% | |
| 57.66% | 111 | 6.0 | 919 | 11,338 | 59.2% | 56.5% | |
| 32.35% | 102 | 5.7 | 578 | 10,251 | 24.4% | 38.6% | |
| 47.96% | 98 | 5.9 | 803 | 13,144 | 34.9% | 58.2% | |
| 47.31% | 93 | 6.2 | 818 | 12,401 | 42.3% | 53.7% | |
| 43.48% | 92 | 5.9 | 891 | 13,431 | 39.4% | 45.8% | |
| 44.19% | 86 | 6.3 | 836 | 13,062 | 48.6% | 41.2% | |
| 44.05% | 84 | 6.2 | 871 | 12,672 | 46.1% | 42.2% | |
| 48.10% | 79 | 5.9 | 905 | 11,646 | 55.6% | 41.9% | |
| 55.13% | 78 | 6.0 | 810 | 11,905 | 58.5% | 51.4% | |
| 56.76% | 74 | 6.2 | 723 | 10,348 | 50.0% | 63.9% | |
| 54.79% | 73 | 6.6 | 1,109 | 13,004 | 45.2% | 61.9% | |
| 46.88% | 64 | 5.7 | 910 | 11,294 | 46.9% | 46.9% | |
| 55.93% | 59 | 5.6 | 1,131 | 12,521 | 52.4% | 57.9% | |
| 57.89% | 57 | 6.9 | 859 | 11,936 | 55.6% | 60.0% | |
| 45.61% | 57 | 6.0 | 1,274 | 11,762 | 42.3% | 48.4% | |
| 42.59% | 54 | 6.4 | 941 | 12,142 | 60.9% | 29.0% | |
| 50.00% | 54 | 6.6 | 857 | 11,433 | 44.4% | 55.6% | |
| 54.72% | 53 | 6.1 | 828 | 11,559 | 58.3% | 51.7% | |
| 43.14% | 51 | 6.1 | 938 | 12,268 | 31.3% | 48.6% | |
| 50.00% | 48 | 6.2 | 996 | 12,519 | 50.0% | 50.0% | |
| 54.55% | 44 | 6.2 | 1,083 | 13,981 | 44.4% | 61.5% | |
| 47.62% | 42 | 5.8 | 806 | 12,730 | 43.8% | 50.0% | |
| 50.00% | 42 | 5.8 | 866 | 11,201 | 45.0% | 54.5% | |
| 58.54% | 41 | 5.9 | 792 | 11,876 | 62.5% | 56.0% | |
| 58.54% | 41 | 6.5 | 1,031 | 13,048 | 70.6% | 50.0% | |
| 65.00% | 40 | 6.2 | 916 | 11,865 | 65.0% | 65.0% | |
| 50.00% | 38 | 6.0 | 742 | 13,144 | 42.9% | 54.2% | |
| 48.65% | 37 | 6.5 | 853 | 12,086 | 55.0% | 41.2% | |
| 35.14% | 37 | 5.9 | 777 | 11,901 | 50.0% | 26.1% | |
| 67.57% | 37 | 6.5 | 855 | 12,230 | 77.8% | 57.9% | |
| 54.05% | 37 | 6.4 | 969 | 13,169 | 61.1% | 47.4% | |
| 44.44% | 36 | 6.2 | 896 | 12,708 | 36.8% | 52.9% | |
| 60.00% | 35 | 6.1 | 977 | 11,949 | 46.1% | 68.2% | |
| 52.94% | 34 | 5.5 | 797 | 11,695 | 53.3% | 52.6% | |
| 50.00% | 34 | 6.2 | 1,068 | 12,203 | 42.9% | 55.0% | |
| 54.55% | 33 | 6.0 | 924 | 13,372 | 40.0% | 66.7% | |
| 48.39% | 31 | 5.9 | 852 | 10,469 | 52.6% | 41.7% | |
| 48.39% | 31 | 6.5 | 866 | 12,866 | 50.0% | 47.1% | |
| 67.74% | 31 | 4.4 | 854 | 11,604 | 66.7% | 69.2% | |
| 53.33% | 30 | 6.2 | 865 | 12,608 | 53.9% | 52.9% | |
| 50.00% | 30 | 5.4 | 786 | 12,084 | 53.9% | 47.1% | |
| 37.93% | 29 | 5.5 | 703 | 9,783 | 26.7% | 50.0% | |
| 57.14% | 28 | 6.5 | 957 | 10,624 | 41.2% | 81.8% | |
| 71.43% | 28 | 5.9 | 680 | 11,426 | 78.6% | 64.3% | |
| 59.26% | 27 | 6.3 | 937 | 11,797 | 63.6% | 56.3% | |
| 50.00% | 26 | 5.4 | 871 | 12,349 | 22.2% | 64.7% | |
| 56.00% | 25 | 6.0 | 822 | 13,134 | 42.9% | 61.1% | |
| 45.83% | 24 | 6.0 | 1,030 | 13,791 | 50.0% | 43.8% | |
| 50.00% | 24 | 6.3 | 873 | 12,593 | 41.7% | 58.3% | |
| 56.52% | 23 | 6.3 | 812 | 11,982 | 60.0% | 53.9% | |
| 59.09% | 22 | 6.3 | 727 | 11,523 | 58.3% | 60.0% | |
| 47.62% | 21 | 6.0 | 813 | 12,780 | 33.3% | 58.3% | |
| 61.90% | 21 | 6.5 | 883 | 12,983 | 50.0% | 66.7% | |
| 55.00% | 20 | 5.4 | 791 | 11,271 | 33.3% | 87.5% | |
| 45.00% | 20 | 5.8 | 687 | 11,190 | 44.4% | 45.5% | |
| 50.00% | 20 | 6.2 | 865 | 13,810 | 50.0% | 50.0% | |
| 60.00% | 20 | 5.6 | 807 | 12,979 | 57.1% | 61.5% | |
| 45.00% | 20 | 6.0 | 935 | 13,265 | 33.3% | 47.1% | |
| 20.00% | 20 | 5.9 | 718 | 11,384 | 10.0% | 30.0% | |
| 40.00% | 20 | 5.2 | 641 | 8,999 | 23.1% | 71.4% | |
| 36.84% | 19 | 6.4 | 719 | 9,910 | 36.4% | 37.5% | |
| 47.37% | 19 | 4.9 | 675 | 11,086 | 45.5% | 50.0% | |
| 38.89% | 18 | 6.5 | 951 | 10,876 | 37.5% | 40.0% | |
| 38.89% | 18 | 6.2 | 1,008 | 10,716 | 30.0% | 50.0% | |
| 61.11% | 18 | 6.1 | 907 | 14,600 | 50.0% | 66.7% | |
| 66.67% | 18 | 3.8 | 999 | 12,924 | 70.0% | 62.5% | |
| 35.29% | 17 | 6.0 | 761 | 11,774 | 28.6% | 40.0% | |
| 25.00% | 16 | 5.9 | 895 | 11,148 | 28.6% | 22.2% | |
| 60.00% | 15 | 4.7 | 1,139 | 13,535 | 57.1% | 62.5% | |
| 53.33% | 15 | 6.6 | 1,076 | 12,723 | 50.0% | 54.5% | |
| 38.46% | 13 | 6.1 | 630 | 9,996 | 50.0% | 20.0% | |
| 53.85% | 13 | 6.0 | 914 | 13,260 | 33.3% | 60.0% | |
| 61.54% | 13 | 6.0 | 1,014 | 15,258 | 0.0% | 72.7% | |
| 53.85% | 13 | 6.8 | 955 | 13,822 | 71.4% | 33.3% | |
| 41.67% | 12 | 3.9 | 802 | 12,003 | 40.0% | 42.9% | |
| 66.67% | 12 | 5.9 | 1,033 | 11,796 | 71.4% | 60.0% | |
| 54.55% | 11 | 6.4 | 713 | 11,807 | 50.0% | 57.1% | |
| 36.36% | 11 | 5.8 | 1,010 | 12,588 | 0.0% | 40.0% | |
| 27.27% | 11 | 6.3 | 726 | 11,430 | 75.0% | 0.0% | |
| 50.00% | 10 | 2.8 | 747 | 12,543 | 20.0% | 80.0% | |
| 70.00% | 10 | 5.6 | 903 | 13,788 | 50.0% | 83.3% | |
| 30.00% | 10 | 3.5 | 537 | 11,030 | 50.0% | 16.7% | |
| 60.00% | 10 | 6.9 | 1,057 | 13,025 | 80.0% | 40.0% | |
| 50.00% | 10 | 5.3 | 705 | 10,529 | 28.6% | 100.0% | |
| 60.00% | 10 | 4.9 | 1,009 | 14,090 | 66.7% | 57.1% | |
| 44.44% | 9 | 6.2 | 787 | 10,080 | 42.9% | 50.0% | |
| 33.33% | 9 | 2.5 | 721 | 12,376 | 20.0% | 50.0% | |
| 55.56% | 9 | 4.6 | 765 | 14,546 | 0.0% | 62.5% | |
| 66.67% | 9 | 2.3 | 836 | 11,944 | 50.0% | 80.0% | |
| 50.00% | 8 | 2.4 | 928 | 10,154 | 40.0% | 66.7% | |
| 62.50% | 8 | 5.2 | 1,041 | 13,725 | 50.0% | 66.7% | |
| 25.00% | 8 | 6.5 | 820 | 13,320 | 25.0% | 25.0% | |
| 57.14% | 7 | 1.4 | 796 | 12,466 | 66.7% | 50.0% | |
| 42.86% | 7 | 6.7 | 984 | 9,410 | 50.0% | 33.3% | |
| 71.43% | 7 | 3.8 | 1,135 | 15,166 | 100.0% | 66.7% | |
| 50.00% | 6 | 4.3 | 996 | 14,686 | 50.0% | 50.0% | |
| 66.67% | 6 | 2.3 | 521 | 7,034 | 50.0% | 100.0% | |
| 33.33% | 6 | 5.8 | 630 | 11,692 | 100.0% | 20.0% | |
| 66.67% | 6 | 6.9 | 1,187 | 14,237 | 100.0% | 33.3% | |
| 50.00% | 6 | 3.1 | 899 | 15,834 | 100.0% | 40.0% | |
| 80.00% | 5 | 2.4 | 1,036 | 14,100 | 100.0% | 75.0% | |
| 80.00% | 5 | 5.1 | 1,036 | 13,354 | 50.0% | 100.0% | |
| 40.00% | 5 | 5.9 | 782 | 7,802 | 0.0% | 100.0% | |
| 80.00% | 5 | 6.2 | 692 | 10,724 | 100.0% | 50.0% | |
| 60.00% | 5 | 2.9 | 968 | 12,859 | 0.0% | 75.0% | |
| 20.00% | 5 | 6.8 | 827 | 8,488 | 25.0% | 0.0% | |
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Vayne vs Lissandra - Frequently Asked Questions
How does Vayne do against Lissandra in League of Legends?
Lissandra wins the Vayne vs Lissandra matchup with a 80.0% win rate compared to Vayne's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.
How does Vayne do against Lissandra in the early game?
In the early game, Lissandra has the advantage against Vayne with a 75.0% win rate versus 25.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Lissandra in the late game?
In the late game, Lissandra takes over the Vayne vs Lissandra matchup with a 100.0% win rate compared to 0.0%. Lissandra scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Lissandra matchup?
Lissandra wins the matchup against Vayne with a 80.0% win rate in League of Legends patch 26.10. The 60.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 5 games analyzed.
What is the best Vayne build against Lissandra?
The best Vayne build against Lissandra includes Jak'Sho, The Protean, Terminus, Blade of The Ruined King with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Lissandra?
The best Vayne runes against Lissandra use the Precision primary tree with Resolve secondary. This rune setup achieves a 50.0% win rate in the Vayne vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Lissandra?
No, Vayne struggles against Lissandra with only a 20.0% win rate. Lissandra has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.
How do I play Vayne against Lissandra?
When playing Vayne against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.