Diana - League of Legends Champion
Win Rate
50.3%
Pick Rate
3.5%

Dianavs Vayne

BFighterAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Diana vs Vayne is a decisive matchup in LoL patch 26.7. Diana wins with a 57.1% win rate (+14.3%) over Vayne based on 7 games. Diana holds the advantage in both the early and late game. Below you'll find the best Diana build, runes, laning stats, and strategies for the Diana vs Vayne matchup.

Diana Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Diana performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 57.1% win rateVayne(57.1%)
Diana - 57.1% win rate in this matchup
Diana
57.1% WR
VS
Vayne vs Diana matchup - 42.9% win rate
Vayne
42.9% WR

Who Wins the Diana vs Vayne Matchup?

Diana wins the Diana vs Vayne matchup
Winner
Diana
Matches: 7
57.1%
Win Rate
42.9%
4.1
CS / min
4.6
933
DMG / min
651
15,594
Gold / game
14,538
164
Heal / min
255
1,440
DMG Mitigated / min
460
0.3
CC / min
0.4
50.0%
Early Game WR
50.0%
60.0%
Late Game WR
40.0%

Diana vs Vayne Matchup Summary

The Diana vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Diana wins with a 57.1% win rate compared to Vayne's 42.9%, giving Diana a 14.3 percentage point advantage. Diana dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Diana leads by 889 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Diana players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Diana vs Vayne Laning Phase Breakdown

Diana wins the laning phase against Vayne in League of Legends

Diana is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Diana holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.1Diana
4.6Vayne
Vayne edges out Diana by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
933Diana
651Vayne
Diana heavily out-damages Vayne by 282 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Diana's sustained damage advantage take over.
Economy
15,594Diana
14,538Vayne
Diana generates a commanding 1,056 more gold per game than Vayne. This substantial economic advantage means Diana consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Diana
0.4Vayne
Both Diana and Vayne provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
1,603Diana
714Vayne
Diana vastly out-sustains Vayne, healing and mitigating 889 more damage per minute. This massive durability gap means Diana can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Diana Build Against Vayne

Mercury's Treads is the optimal boots choice against Vayne, providing the mobility and stats Diana needs most in this matchup. The top-performing core items for Diana against Vayne are Luden's Echo, Randuin's Omen and Void Staff. This combination gives Diana an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Diana vs Vayne matchup.

Early Game vs Late Game

Early Game
Diana
50.0%
+0.0% advantage
Diana early game win rateDiana50.0%
Vayne early game win rateVayne50.0%
Late Game
Diana
60.0%
+20.0% advantage
Diana late game win rateDiana60.0%
Vayne late game win rateVayne40.0%

The early game (first 15 minutes) is a toss-up between Diana and Vayne, with Diana holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Diana is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Vayne. Extended games heavily favor Diana, whose kit and scaling make them a dominant force in team fights and objective control.

Diana holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Diana Runes Against Vayne

Domination rune tree - Diana primary runes vs VayneDomination
Electrocute - best Diana rune vs VayneSudden Impact - best Diana rune vs VayneGrisly Mementos - best Diana rune vs VayneTreasure Hunter - best Diana rune vs Vayne
Sorcery rune tree - Diana secondary runes vs VayneSorcery
Manaflow Band - best Diana rune vs VayneScorch - best Diana rune vs Vayne
100.0% WR

Running Domination primary with Sorcery secondary allows Diana to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Diana matchup data for League of Legends patch 26.7. The table below shows Diana's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Diana build, runes, laning stats, and early vs late game analysis for that specific matchup.

Diana matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
51.89%1066.089612,54257.5%47.5%
46.88%961.470112,76850.9%41.5%
44.21%951.368512,66154.4%34.7%
53.41%881.674013,05457.1%50.0%
40.48%845.886012,46647.1%36.0%
46.91%811.475312,44346.5%47.4%
51.90%796.181713,19263.3%44.9%
52.56%781.479714,27665.6%43.5%
48.00%754.385011,97651.2%43.8%
49.33%755.693312,65248.6%50.0%
37.84%741.575313,37843.8%33.3%
49.30%714.089713,29055.6%45.5%
56.52%691.777913,48154.8%57.9%
54.41%686.295413,29353.6%55.0%
49.23%655.988112,35254.8%44.1%
45.31%645.985611,96039.4%51.6%
46.03%636.286512,22342.9%48.6%
57.14%635.286312,40456.0%57.9%
56.14%576.099812,19848.3%64.3%
52.63%575.786911,31251.7%53.6%
51.79%565.889712,43761.3%40.0%
59.26%543.492514,29169.6%51.6%
37.74%531.485012,88538.5%37.0%
49.02%515.990612,44340.9%55.2%
43.48%466.079511,94447.6%40.0%
54.35%461.478313,55643.8%60.0%
50.00%446.088311,93163.6%36.4%
35.71%426.385411,48334.8%36.8%
53.66%411.680112,95545.8%64.7%
47.50%401.470113,41960.0%40.0%
41.03%393.982312,59941.2%40.9%
36.84%386.079011,31343.8%31.8%
59.46%371.274213,67770.6%50.0%
45.95%371.270211,96142.1%50.0%
57.14%356.093313,40884.6%40.9%
57.14%351.569112,15855.6%58.8%
52.94%341.170412,14460.0%47.4%
66.67%336.185011,57864.7%68.8%
78.79%335.61,00112,83776.9%80.0%
43.75%322.178513,77363.6%33.3%
46.88%321.373512,19350.0%41.7%
48.39%312.477212,71258.3%42.1%
41.94%311.687112,54741.2%42.9%
43.33%302.685311,67244.4%41.7%
63.33%305.486912,21650.0%72.2%
51.72%291.480413,53753.9%50.0%
48.28%291.690912,53643.8%53.9%
68.97%296.091612,06478.6%60.0%
57.14%281.485214,01960.0%55.6%
53.57%285.792812,38961.5%46.7%
48.15%271.477814,61054.5%43.8%
70.37%276.289511,94770.6%70.0%
48.15%271.372012,15558.3%40.0%
66.67%271.381013,65066.7%66.7%
34.62%261.877813,33946.1%23.1%
46.15%265.196812,22146.1%46.1%
44.00%251.376813,35750.0%38.5%
58.33%241.477612,85150.0%64.3%
54.17%246.096714,32850.0%56.3%
47.83%234.084712,72941.7%54.5%
45.45%225.997413,21462.5%35.7%
40.91%226.286011,64246.1%33.3%
61.90%212.172611,96375.0%44.4%
60.00%201.475311,43275.0%50.0%
50.00%202.377113,59650.0%50.0%
57.89%191.397714,94566.7%53.9%
42.11%191.368212,09644.4%40.0%
50.00%182.076912,25945.5%57.1%
44.44%181.786813,91571.4%27.3%
55.56%182.367012,44961.5%40.0%
52.94%174.782913,10642.9%60.0%
52.94%171.480313,45866.7%37.5%
23.53%171.164812,15833.3%12.5%
52.94%175.883812,18042.9%60.0%
50.00%165.81,01513,10450.0%50.0%
62.50%166.396912,462100.0%40.0%
66.67%156.292714,08450.0%69.2%
46.67%152.368711,71866.7%16.7%
26.67%154.371711,86828.6%25.0%
50.00%146.497312,83262.5%33.3%
42.86%144.783712,24244.4%40.0%
42.86%143.075512,08133.3%50.0%
42.86%141.177810,99940.0%50.0%
64.29%145.81,05113,62275.0%60.0%
35.71%143.179512,92340.0%33.3%
64.29%144.992712,45550.0%75.0%
69.23%135.093912,965100.0%60.0%
53.85%131.691514,04340.0%62.5%
76.92%136.29229,86080.0%66.7%
75.00%121.971412,01087.5%50.0%
66.67%121.872012,10557.1%80.0%
45.45%115.579012,30650.0%40.0%
36.36%114.81,03513,43066.7%25.0%
27.27%115.673210,89250.0%0.0%
63.64%115.61,14912,88840.0%83.3%
50.00%104.175515,05550.0%50.0%
44.44%91.681313,79733.3%50.0%
44.44%96.993512,81933.3%66.7%
66.67%91.174611,69150.0%100.0%
44.44%94.685913,10650.0%42.9%
44.44%96.288710,78366.7%0.0%
25.00%81.553810,59320.0%33.3%
28.57%73.173810,93950.0%0.0%
28.57%74.585512,06650.0%0.0%
42.86%72.496015,10150.0%40.0%
28.57%75.21,07713,66666.7%0.0%
57.14%74.193315,59450.0%60.0%
42.86%75.51,01017,0430.0%42.9%
50.00%65.592814,6800.0%50.0%
40.00%54.91,04313,7690.0%50.0%
60.00%50.972312,17550.0%100.0%
20.00%57.098212,74733.3%0.0%
40.00%51.273513,08766.7%0.0%
80.00%56.077510,838100.0%50.0%
40.00%53.288714,90233.3%50.0%

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Diana vs Vayne - Frequently Asked Questions

How does Diana do against Vayne in League of Legends?

Diana wins the Diana vs Vayne matchup with a 57.1% win rate compared to Vayne's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.7.

How does Diana do against Vayne in the early game?

In the early game, Diana has the advantage against Vayne with a 50.0% win rate versus 50.0%. Diana players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Diana do against Vayne in the late game?

In the late game, Diana takes over the Diana vs Vayne matchup with a 60.0% win rate compared to 40.0%. Diana scales better into team fights and objective contests after 25 minutes.

Who wins the Diana vs Vayne matchup?

Diana wins the matchup against Vayne with a 57.1% win rate in League of Legends patch 26.7. The 14.3 percentage point advantage means Diana is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Diana build against Vayne?

The best Diana build against Vayne includes Luden's Echo, Randuin's Omen, Void Staff with Mercury's Treads. Check the matchup breakdown above for the full item path and build order.

What are the best Diana runes against Vayne?

The best Diana runes against Vayne use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Diana vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Diana counter Vayne?

Yes, Diana has a favorable matchup against Vayne with a 57.1% win rate. Diana strongly counters Vayne in lane based on current patch 26.7 data.

How do I play Diana against Vayne?

When playing Diana against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.