Vayne - League of Legends Champion
Win Rate
48.1%
Pick Rate
7.4%

Vaynevs Warwick

FMarksmanAssassin
Patch26.9
Matches139,310
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 1, 2026
MethodologyData Methodology

Vayne vs Warwick is a decisive matchup in LoL patch 26.9. Vayne wins with a 75.0% win rate (+50.0%) over Warwick based on 8 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Warwick matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Warwick - 75.0% win rateWarwick(75.0%)
Vayne - 75.0% win rate in this matchup
Vayne
75.0% WR
VS
Warwick vs Vayne matchup - 25.0% win rate
Warwick
25.0% WR

Who Wins the Vayne vs Warwick Matchup?

Vayne wins the Vayne vs Warwick matchup
Winner
Vayne
Matches: 8
75.0%
Win Rate
25.0%
2.2
CS / min
2.2
819
DMG / min
587
12,301
Gold / game
11,400
305
Heal / min
618
599
DMG Mitigated / min
1,313
0.5
CC / min
0.9
66.7%
Early Game WR
33.3%
80.0%
Late Game WR
20.0%

Vayne vs Warwick Matchup Summary

The Vayne vs Warwick matchup is a decisive matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Vayne wins with a 75.0% win rate compared to Warwick's 25.0%, giving Vayne a 50.0 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Warwick players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Warwick leads by 1,026 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Warwick and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Warwick away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Warwick Laning Phase Breakdown

Warwick wins the laning phase against Vayne in League of Legends

Warwick is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Warwick holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
2.2Vayne
2.2Warwick
Vayne and Warwick farm at nearly identical rates in this matchup, with only a 0.0 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
819Vayne
587Warwick
Vayne heavily out-damages Warwick by 232 DMG/min, dominating both short trades and all-in fights. Warwick should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
12,301Vayne
11,400Warwick
Vayne generates a commanding 901 more gold per game than Warwick. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Warwick should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.5Vayne
0.9Warwick
Warwick provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Warwick coordinate with their jungler and control the pace of skirmishes.
Sustain
904Vayne
1,931Warwick
Warwick vastly out-sustains Vayne, healing and mitigating 1,026 more damage per minute. This massive durability gap means Warwick can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Warwick

Boots of Swiftness is the optimal boots choice against Warwick, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Warwick are Essence Reaver, Mortal Reminder and Infinity Edge. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Warwick. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Warwick matchup.

Early Game vs Late Game

Early Game
Vayne
66.7%
+33.3% advantage
Vayne early game win rateVayne66.7%
Warwick early game win rateWarwick33.3%
Late Game
Vayne
80.0%
+60.0% advantage
Vayne late game win rateVayne80.0%
Warwick late game win rateWarwick20.0%

Vayne dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Warwick. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 80.0% win rate — 60.0 points above Warwick. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Warwick players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Warwick

Precision rune tree - Vayne primary runes vs WarwickPrecision
Lethal Tempo - best Vayne rune vs WarwickAbsorb Life - best Vayne rune vs WarwickLegend: Alacrity - best Vayne rune vs WarwickCut Down - best Vayne rune vs Warwick
Domination rune tree - Vayne secondary runes vs WarwickDomination
Sudden Impact - best Vayne rune vs WarwickUltimate Hunter - best Vayne rune vs Warwick
100.0% WR

Running Precision primary with Domination secondary allows Vayne to press their advantage against Warwick, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.9. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
43.36%1436.173412,78843.9%43.0%
48.09%1316.081312,68644.8%50.7%
47.11%1216.579812,79351.8%43.1%
41.59%1135.874812,06144.0%39.7%
47.75%1116.183512,49245.6%50.0%
48.11%1066.277912,94945.8%50.0%
50.52%976.187313,22350.0%50.9%
62.34%786.387513,96861.8%62.8%
58.33%486.593212,56861.9%55.6%
39.58%486.184312,29238.1%40.7%
39.53%436.188513,45415.8%58.3%
38.89%366.477012,72750.0%30.0%
42.86%355.789413,03950.0%38.1%
47.06%345.971311,98740.0%52.6%
40.63%325.865511,87829.4%53.3%
42.86%286.685414,30936.4%47.1%
46.15%266.095312,87841.7%50.0%
42.31%266.479912,51141.7%42.9%
40.00%256.077512,77520.0%53.3%
44.00%255.653710,45030.8%58.3%
75.00%246.389713,78072.7%76.9%
40.91%226.16429,68320.0%58.3%
63.64%226.281012,48760.0%66.7%
68.42%195.71,00014,84225.0%80.0%
38.89%186.274011,13150.0%30.0%
47.06%176.195113,19360.0%41.7%
64.71%177.11,06510,24858.3%80.0%
43.75%166.283913,39250.0%40.0%
43.75%166.397811,68857.1%33.3%
46.67%155.885811,74433.3%55.6%
66.67%156.59019,31866.7%66.7%
66.67%156.092010,90942.9%87.5%
53.33%156.51,01812,46562.5%42.9%
66.67%156.91,30715,28166.7%66.7%
23.08%136.01,01812,91660.0%0.0%
46.15%135.568211,44937.5%60.0%
53.85%136.490313,03466.7%42.9%
50.00%126.21,02412,71050.0%50.0%
25.00%126.078611,72425.0%25.0%
50.00%127.289010,08237.5%75.0%
50.00%126.283310,20775.0%0.0%
50.00%126.21,14612,89842.9%60.0%
58.33%126.084212,17860.0%57.1%
27.27%116.67039,29414.3%50.0%
54.55%117.384215,25933.3%62.5%
54.55%116.26979,84260.0%50.0%
36.36%115.61,27710,56860.0%16.7%
30.00%105.996711,11333.3%25.0%
70.00%106.61,12313,022100.0%62.5%
70.00%106.597112,45260.0%80.0%
44.44%96.089214,39250.0%40.0%
55.56%95.787813,141100.0%33.3%
66.67%95.895313,93166.7%66.7%
77.78%95.678915,1590.0%77.8%
44.44%95.669211,54542.9%50.0%
33.33%96.98079,64050.0%20.0%
22.22%95.86478,56133.3%0.0%
55.56%96.31,04215,53250.0%57.1%
62.50%86.11,15517,47050.0%66.7%
25.00%86.394912,24533.3%20.0%
25.00%85.25759,93850.0%16.7%
75.00%82.281912,30166.7%80.0%
75.00%85.255611,55666.7%80.0%
75.00%87.27628,980100.0%33.3%
75.00%85.876913,349100.0%60.0%
57.14%76.17479,52060.0%50.0%
28.57%74.868010,52233.3%25.0%
71.43%76.395213,3200.0%83.3%
28.57%75.770611,2610.0%50.0%
28.57%76.775311,27425.0%33.3%
57.14%76.888113,98050.0%60.0%
33.33%65.252411,0470.0%50.0%
50.00%65.97609,98933.3%66.7%
66.67%65.36999,09175.0%50.0%
66.67%66.896313,360100.0%50.0%
33.33%64.763012,3750.0%33.3%
16.67%65.673911,4730.0%50.0%
66.67%66.486711,48250.0%100.0%
33.33%64.496412,7940.0%40.0%
16.67%65.25858,2640.0%50.0%
33.33%66.190414,2660.0%50.0%
20.00%55.91,05313,5650.0%33.3%
60.00%56.91,23310,7300.0%100.0%
40.00%56.381111,359100.0%25.0%
20.00%55.988612,7340.0%33.3%
40.00%56.31,13214,904100.0%25.0%
0.00%57.185313,2270.0%0.0%
60.00%56.61,08816,12050.0%66.7%
40.00%56.87839,69066.7%0.0%
40.00%51.079513,1890.0%66.7%
60.00%56.21,21314,9630.0%75.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Vayne vs Warwick - Frequently Asked Questions

How does Vayne do against Warwick in League of Legends?

Vayne wins the Vayne vs Warwick matchup with a 75.0% win rate compared to Warwick's 25.0%, a 50.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.9.

How does Vayne do against Warwick in the early game?

In the early game, Vayne has the advantage against Warwick with a 66.7% win rate versus 33.3%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Warwick in the late game?

In the late game, Vayne takes over the Vayne vs Warwick matchup with a 80.0% win rate compared to 20.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Warwick matchup?

Vayne wins the matchup against Warwick with a 75.0% win rate in League of Legends patch 26.9. The 50.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 8 games analyzed.

What is the best Vayne build against Warwick?

The best Vayne build against Warwick includes Essence Reaver, Mortal Reminder, Infinity Edge with Boots of Swiftness. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Warwick?

The best Vayne runes against Warwick use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Warwick matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Warwick?

Yes, Vayne has a favorable matchup against Warwick with a 75.0% win rate. Vayne strongly counters Warwick in lane based on current patch 26.9 data.

How do I play Vayne against Warwick?

When playing Vayne against Warwick, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.