Vayne - League of Legends Champion
Win Rate
49.8%
Pick Rate
5.2%

Vaynevs Warwick

CMarksmanAssassin
Patch26.12
Matches328,930
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 24, 2026
MethodologyData Methodology

Vayne vs Warwick is a very close matchup in LoL patch 26.12. Vayne wins with a 50.0% win rate (+0.0%) over Warwick based on 6 games. Warwick wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Warwick matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 50.0% win rate in this matchup
Vayne
50.0% WR
VS
Warwick vs Vayne matchup - 50.0% win rate
Warwick
50.0% WR

Who Wins the Vayne vs Warwick Matchup?

Vayne wins the Vayne vs Warwick matchup
Winner
Vayne
Matches: 6
50.0%
Win Rate
50.0%
4.0
CS / min
4.7
715
DMG / min
734
7,560
Gold / game
8,075
186
Heal / min
611
414
DMG Mitigated / min
1,387
0.4
CC / min
0.9
40.0%
Early Game WR
60.0%
100.0%
Late Game WR
0.0%

Vayne vs Warwick Matchup Summary

The Vayne vs Warwick matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Vayne wins with a 50.0% win rate compared to Warwick's 50.0%, giving Vayne a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Warwick controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Warwick needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Warwick leads by 1,399 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a statistical edge, but the margin is close enough that respecting Warwick's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Warwick Laning Phase Breakdown

Warwick wins the laning phase against Vayne in League of Legends

Warwick is favored during the laning phase against Vayne, winning 5 out of 5 key stat categories. Warwick holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
4.0Vayne
4.7Warwick
Warwick edges out Vayne by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 10 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Warwick.
Damage
715Vayne
734Warwick
Damage output is virtually even between Vayne and Warwick, with only 19 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
7,560Vayne
8,075Warwick
Warwick earns 515 more gold per game than Vayne, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Warwick slightly faster item completions.
Utility
0.4Vayne
0.9Warwick
Warwick provides 0.5 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Warwick coordinate with their jungler and control the pace of skirmishes.
Sustain
599Vayne
1,998Warwick
Warwick vastly out-sustains Vayne, healing and mitigating 1,399 more damage per minute. This massive durability gap means Warwick can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Warwick

Berserker's Greaves is the optimal boots choice against Warwick, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Warwick are Kraken Slayer, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Warwick. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Warwick matchup.

Early Game vs Late Game

Early Game
Warwick
60.0%
+20.0% advantage
Vayne early game win rateVayne40.0%
Warwick early game win rateWarwick60.0%
Late Game
Vayne
100.0%
+100.0% advantage
Vayne late game win rateVayne100.0%
Warwick late game win rateWarwick0.0%

Warwick dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Vayne. This lopsided early game means Warwick can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Warwick. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Warwick must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Warwick

Precision rune tree - Vayne primary runes vs WarwickPrecision
Press the Attack - best Vayne rune vs WarwickTriumph - best Vayne rune vs WarwickLegend: Alacrity - best Vayne rune vs WarwickCut Down - best Vayne rune vs Warwick
Resolve rune tree - Vayne secondary runes vs WarwickResolve
Conditioning - best Vayne rune vs WarwickOvergrowth - best Vayne rune vs Warwick
100.0% WR

The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Warwick.


Vayne matchup data for League of Legends patch 26.12. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.12
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.71%2105.977312,83341.6%48.8%
46.07%1786.285113,20756.3%39.3%
44.17%1636.283312,80145.7%42.7%
52.74%1465.978212,82153.2%52.4%
46.76%1396.081213,22944.4%48.7%
44.54%1195.980412,74931.4%54.4%
51.65%916.292014,12457.6%48.3%
51.11%906.184012,78242.9%58.3%
48.86%886.281713,03646.0%51.0%
44.87%786.179212,38141.5%48.6%
52.63%766.287213,35945.7%58.5%
61.54%656.075612,86355.6%69.0%
55.74%616.393513,53069.2%45.7%
42.86%566.289013,22733.3%51.7%
58.49%536.994812,33542.9%68.8%
53.19%476.186213,83342.9%61.5%
30.23%436.188514,15537.5%25.9%
47.50%406.279712,89156.3%41.7%
50.00%386.384712,47753.9%48.0%
36.84%385.75868,96730.4%46.7%
52.63%386.180212,00076.5%33.3%
45.95%376.091610,86562.5%33.3%
61.11%366.289113,85940.0%76.2%
48.57%356.694614,82461.5%40.9%
51.61%316.31,16913,79840.0%57.1%
67.74%316.385211,38275.0%60.0%
48.39%315.870411,33550.0%47.1%
29.03%315.865212,04533.3%25.0%
48.15%276.091412,97950.0%47.4%
37.04%276.71,25011,24550.0%23.1%
50.00%246.085311,59240.0%57.1%
45.45%226.884714,18722.2%61.5%
40.91%226.21,07311,53046.1%33.3%
45.45%225.61,05110,76933.3%53.9%
25.00%206.088112,05050.0%8.3%
40.00%206.294611,39360.0%33.3%
52.63%196.074712,20450.0%54.5%
68.42%195.985113,36558.3%85.7%
52.63%196.183412,66740.0%66.7%
31.58%196.284713,06111.1%50.0%
50.00%186.387812,32740.0%53.9%
55.56%185.974611,78163.6%42.9%
50.00%186.383913,91150.0%50.0%
41.18%176.177512,03766.7%27.3%
52.94%176.576510,20666.7%37.5%
47.06%176.277813,18228.6%60.0%
62.50%166.499813,59757.1%66.7%
62.50%166.699411,03242.9%77.8%
46.67%155.673711,11566.7%41.7%
40.00%156.685410,88216.7%55.6%
33.33%156.172611,17333.3%33.3%
50.00%146.690711,75142.9%57.1%
21.43%146.15679,09522.2%20.0%
64.29%146.31,04611,89257.1%71.4%
64.29%146.697612,16850.0%75.0%
71.43%146.184911,83460.0%77.8%
69.23%136.71,13013,84875.0%66.7%
61.54%136.478911,12057.1%66.7%
33.33%125.866211,82160.0%14.3%
25.00%126.576312,31525.0%25.0%
58.33%126.374311,69466.7%50.0%
91.67%126.797414,182100.0%88.9%
16.67%126.57239,2960.0%50.0%
50.00%125.874611,47455.6%33.3%
40.00%106.076210,65528.6%66.7%
50.00%106.295312,22383.3%0.0%
44.44%96.283611,30425.0%60.0%
44.44%95.561813,6680.0%50.0%
55.56%94.464113,10550.0%57.1%
55.56%96.51,15617,999100.0%42.9%
50.00%84.785412,30133.3%60.0%
50.00%86.163110,92633.3%100.0%
62.50%86.11,14315,40666.7%60.0%
25.00%87.31,01112,5600.0%50.0%
25.00%86.179112,37966.7%0.0%
50.00%85.760010,34833.3%100.0%
57.14%76.275612,70975.0%33.3%
42.86%76.18539,11133.3%100.0%
42.86%76.68349,07050.0%33.3%
28.57%76.27728,7050.0%50.0%
16.67%65.773212,5480.0%33.3%
50.00%64.07157,56040.0%100.0%
83.33%65.692316,5600.0%83.3%
50.00%65.467910,488100.0%25.0%
16.67%66.362910,27425.0%0.0%
33.33%63.586613,64666.7%0.0%
16.67%65.35569,8130.0%50.0%
50.00%66.472911,78950.0%50.0%
40.00%53.669711,33750.0%33.3%
80.00%55.681710,869100.0%50.0%
60.00%56.393115,2820.0%60.0%
60.00%56.01,09515,11650.0%66.7%
0.00%55.582112,2020.0%0.0%
40.00%57.088715,3880.0%50.0%
40.00%54.891513,07533.3%50.0%
80.00%56.77799,60675.0%100.0%
60.00%55.869413,863100.0%50.0%
20.00%56.585811,979100.0%0.0%

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Vayne vs Warwick - Frequently Asked Questions

How does Vayne do against Warwick in League of Legends?

Vayne wins the Vayne vs Warwick matchup with a 50.0% win rate compared to Warwick's 50.0%, a 0.0 percentage point difference. This data is based on 6 recent ranked games in patch 26.12.

How does Vayne do against Warwick in the early game?

In the early game, Warwick has the advantage against Vayne with a 60.0% win rate versus 40.0%. Warwick players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Warwick in the late game?

In the late game, Vayne takes over the Vayne vs Warwick matchup with a 100.0% win rate compared to 0.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Warwick matchup?

Vayne wins the matchup against Warwick with a 50.0% win rate in League of Legends patch 26.12. The 0.0 percentage point advantage means Vayne is slightly favored in this lane matchup based on 6 games analyzed.

What is the best Vayne build against Warwick?

The best Vayne build against Warwick includes Kraken Slayer, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Warwick?

The best Vayne runes against Warwick use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Warwick matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Warwick?

Yes, Vayne has a favorable matchup against Warwick with a 50.0% win rate. Vayne slightly edges out Warwick in lane based on current patch 26.12 data.

How do I play Vayne against Warwick?

When playing Vayne against Warwick, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Warwick. Build the recommended items and runes for this specific matchup for the best results.