Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Annie

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 26, 2026
MethodologyData Methodology

Vayne vs Annie is a very close matchup in LoL patch 26.7. Vayne wins with a 50.0% win rate (+0.0%) over Annie based on 6 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Annie matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Annie - 50.0% win rateAnnie(50.0%)
Vayne - 50.0% win rate in this matchup
Vayne
50.0% WR
VS
Annie vs Vayne matchup - 50.0% win rate
Annie
50.0% WR

Who Wins the Vayne vs Annie Matchup?

Vayne wins the Vayne vs Annie matchup
Winner
Vayne
Matches: 6
50.0%
Win Rate
50.0%
5.7
CS / min
5.4
762
DMG / min
1,195
13,182
Gold / game
14,593
217
Heal / min
89
534
DMG Mitigated / min
560
0.3
CC / min
1.2
50.0%
Early Game WR
50.0%
50.0%
Late Game WR
50.0%

Vayne vs Annie Matchup Summary

The Vayne vs Annie matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Vayne wins with a 50.0% win rate compared to Annie's 50.0%, giving Vayne a 0.0 percentage point advantage. Vayne holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Annie can still find windows through outplays and team coordination. The most significant statistical gap is in crowd control, where Annie leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a statistical edge, but the margin is close enough that respecting Annie's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Annie Laning Phase Breakdown

Annie wins the laning phase against Vayne in League of Legends

Annie is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Annie holds advantages in damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
5.7Vayne
5.4Annie
Vayne and Annie farm at nearly identical rates in this matchup, with only a 0.3 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
762Vayne
1,195Annie
Annie heavily out-damages Vayne by 433 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
13,182Vayne
14,593Annie
Annie generates a commanding 1,410 more gold per game than Vayne. This substantial economic advantage means Annie consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Vayne
1.2Annie
Annie brings significantly more crowd control than Vayne, with 0.8 more seconds of CC per minute. This large utility gap makes Annie far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
751Vayne
649Annie
Vayne heals and mitigates 102 more damage per minute than Annie, providing moderate extra durability. This sustain edge allows Vayne to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Annie.

Best Vayne Build Against Annie

Mercury's Treads is the optimal boots choice against Annie, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Annie are Kraken Slayer, Wit's End and Fiendhunter Bolts. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Annie matchup.

Early Game vs Late Game

Early Game
Vayne
50.0%
+0.0% advantage
Vayne early game win rateVayne50.0%
Annie early game win rateAnnie50.0%
Late Game
Vayne
50.0%
+0.0% advantage
Vayne late game win rateVayne50.0%
Annie late game win rateAnnie50.0%

The early game (first 15 minutes) is a toss-up between Vayne and Annie, with Vayne holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Late game (25+ minutes) is equally balanced, with Vayne at 50.0% win rate — only 0.0 points ahead of Annie. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

This matchup is remarkably even at every stage of the game. Neither Vayne nor Annie has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.

Best Vayne Runes Against Annie

Precision rune tree - Vayne primary runes vs AnniePrecision
Press the Attack - best Vayne rune vs AnnieTriumph - best Vayne rune vs AnnieLegend: Alacrity - best Vayne rune vs AnnieCoup de Grace - best Vayne rune vs Annie
Resolve rune tree - Vayne secondary runes vs AnnieResolve
Conditioning - best Vayne rune vs AnnieOvergrowth - best Vayne rune vs Annie
100.0% WR

The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Annie.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Annie - Frequently Asked Questions

How does Vayne do against Annie in League of Legends?

Vayne wins the Vayne vs Annie matchup with a 50.0% win rate compared to Annie's 50.0%, a 0.0 percentage point difference. This data is based on 6 recent ranked games in patch 26.7.

How does Vayne do against Annie in the early game?

In the early game, Vayne has the advantage against Annie with a 50.0% win rate versus 50.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Annie in the late game?

In the late game, Vayne takes over the Vayne vs Annie matchup with a 50.0% win rate compared to 50.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Annie matchup?

Vayne wins the matchup against Annie with a 50.0% win rate in League of Legends patch 26.7. The 0.0 percentage point advantage means Vayne is slightly favored in this lane matchup based on 6 games analyzed.

What is the best Vayne build against Annie?

The best Vayne build against Annie includes Kraken Slayer, Wit's End, Fiendhunter Bolts with Mercury's Treads. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Annie?

The best Vayne runes against Annie use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Annie?

Yes, Vayne has a favorable matchup against Annie with a 50.0% win rate. Vayne slightly edges out Annie in lane based on current patch 26.7 data.

How do I play Vayne against Annie?

When playing Vayne against Annie, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.