Vayne - League of Legends Champion
Win Rate
48.6%
Pick Rate
5.5%

Vaynevs Annie

FMarksmanAssassin
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 12, 2026
MethodologyData Methodology

Vayne vs Annie is a decisive matchup in LoL patch 26.5. Annie wins with a 83.3% win rate (+66.7%) over Vayne based on 6 games. Annie wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Annie matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Annie - 16.7% win rateAnnie(16.7%)
Vayne - 16.7% win rate in this matchup
Vayne
16.7% WR
VS
Annie vs Vayne matchup - 83.3% win rate
Annie
83.3% WR

Who Wins the Vayne vs Annie Matchup?

Annie wins the Vayne vs Annie matchup
Winner
Annie
Matches: 6
16.7%
Win Rate
83.3%
6.3
CS / min
6.1
664
DMG / min
1,000
11,656
Gold / game
12,399
204
Heal / min
103
478
DMG Mitigated / min
426
0.4
CC / min
1.3
0.0%
Early Game WR
100.0%
50.0%
Late Game WR
50.0%

Vayne vs Annie Matchup Summary

The Vayne vs Annie matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Annie wins with a 83.3% win rate compared to Vayne's 16.7%, giving Annie a 66.7 percentage point advantage. Game phase dynamics play a critical role here: Annie controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Annie needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Annie leads by 0.9s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Annie has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Annie overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Annie Laning Phase Breakdown

Annie wins the laning phase against Vayne in League of Legends

Annie is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Annie holds advantages in damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.3Vayne
6.1Annie
Vayne and Annie farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
664Vayne
1,000Annie
Annie heavily out-damages Vayne by 336 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
11,656Vayne
12,399Annie
Annie earns 743 more gold per game than Vayne, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Annie slightly faster item completions.
Utility
0.4Vayne
1.3Annie
Annie brings significantly more crowd control than Vayne, with 0.9 more seconds of CC per minute. This large utility gap makes Annie far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
683Vayne
529Annie
Vayne vastly out-sustains Annie, healing and mitigating 153 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Annie

Berserker's Greaves is the optimal boots choice against Annie, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Annie are Stormrazor, Experimental Hexplate and Infinity Edge. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Annie matchup.

Early Game vs Late Game

Early Game
Annie
100.0%
+100.0% advantage
Vayne early game win rateVayne0.0%
Annie early game win rateAnnie100.0%
Late Game
Vayne
50.0%
+0.0% advantage
Vayne late game win rateVayne50.0%
Annie late game win rateAnnie50.0%

Annie dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Vayne. This lopsided early game means Annie can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Vayne at 50.0% win rate — only 0.0 points ahead of Annie. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Annie has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Vayne Runes Against Annie

Precision rune tree - Vayne primary runes vs AnniePrecision
Press the Attack - best Vayne rune vs AnnieTriumph - best Vayne rune vs AnnieLegend: Alacrity - best Vayne rune vs AnnieCoup de Grace - best Vayne rune vs Annie
Resolve rune tree - Vayne secondary runes vs AnnieResolve
Conditioning - best Vayne rune vs AnnieOvergrowth - best Vayne rune vs Annie
100.0% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Annie in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.5. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.5
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.19%3436.081313,33642.9%47.1%
50.32%3126.386513,63654.4%46.6%
44.63%2985.883113,48143.4%45.6%
46.62%2966.185113,46647.8%45.9%
55.98%2346.394614,23250.9%60.3%
45.37%2055.982213,19041.3%48.7%
57.37%1906.293413,51955.0%59.6%
50.27%1856.492614,20251.3%49.5%
52.17%1386.087713,59861.1%46.4%
44.44%1356.084712,23336.6%53.1%
48.51%1346.188012,68251.9%43.4%
51.49%1015.874111,57147.3%56.5%
40.00%1006.088214,17237.1%41.5%
47.47%996.483712,99350.0%44.9%
56.38%946.794411,82157.5%55.3%
44.09%936.290713,01535.7%51.0%
52.22%906.391113,74951.1%53.3%
40.48%846.085112,97631.7%48.8%
50.72%695.776712,52155.9%45.7%
52.63%576.283813,31450.0%54.5%
34.62%526.395913,63831.8%36.7%
57.69%526.196012,54854.5%60.0%
41.18%516.285312,27948.5%27.8%
50.00%505.568411,26038.1%58.6%
43.75%486.51,01312,48033.3%51.9%
40.43%475.784412,83729.4%46.7%
65.22%466.296712,43861.1%67.9%
52.17%466.21,01012,67847.8%56.5%
48.89%456.699912,37159.1%39.1%
52.27%446.51,03313,51152.0%52.6%
45.45%446.079814,09853.3%41.4%
46.15%396.389214,12553.3%41.7%
42.11%386.479012,60133.3%50.0%
63.16%386.383113,35747.4%79.0%
67.57%376.396314,55771.4%65.2%
45.95%376.31,37311,58353.3%40.9%
52.78%366.31,10412,11147.1%57.9%
44.12%345.763811,24831.6%60.0%
39.39%336.273410,82136.8%42.9%
53.13%326.596512,72560.0%47.1%
56.25%325.585813,96854.5%57.1%
58.06%316.490711,97952.9%64.3%
58.62%296.296911,37443.8%76.9%
46.43%286.991912,21946.7%46.1%
64.00%256.31,02314,55170.0%60.0%
48.00%255.896712,69330.0%60.0%
60.00%255.31,14214,27050.0%64.7%
34.78%236.188611,70225.0%45.5%
52.17%236.399912,43053.9%50.0%
34.78%236.579510,27233.3%37.5%
39.13%236.294012,38540.0%38.5%
59.09%226.11,09515,40466.7%53.9%
50.00%226.084811,68446.1%55.6%
52.38%216.789513,74242.9%57.1%
42.86%216.41,11512,73066.7%25.0%
42.86%215.780511,35554.5%30.0%
42.86%216.299313,73433.3%46.7%
30.00%206.278811,78912.5%41.7%
45.00%206.080413,90042.9%46.1%
50.00%206.792713,34650.0%50.0%
42.11%196.780412,20155.6%30.0%
44.44%186.282014,48466.7%33.3%
52.94%176.282312,99350.0%55.6%
47.06%176.287711,43133.3%62.5%
58.82%176.690312,86266.7%50.0%
18.75%166.169211,33920.0%16.7%
66.67%156.799012,94866.7%66.7%
40.00%155.71,02813,5380.0%54.5%
50.00%146.591410,06354.5%33.3%
50.00%146.066211,40566.7%37.5%
78.57%146.71,12013,87875.0%80.0%
64.29%145.51,19413,06842.9%85.7%
61.54%137.089912,63783.3%42.9%
61.54%136.577612,07957.1%66.7%
25.00%126.575113,23414.3%40.0%
63.64%115.888913,83040.0%83.3%
50.00%105.91,06512,9710.0%71.4%
50.00%105.172010,51642.9%66.7%
33.33%96.581813,63450.0%28.6%
55.56%94.01,17914,12666.7%50.0%
33.33%96.179712,20050.0%20.0%
66.67%93.888213,55066.7%66.7%
66.67%97.087613,88860.0%75.0%
44.44%96.292911,87540.0%50.0%
37.50%82.762111,38833.3%40.0%
25.00%85.797814,065100.0%0.0%
37.50%86.187413,9500.0%42.9%
62.50%86.51,01112,94550.0%75.0%
62.50%86.968412,92466.7%60.0%
75.00%86.11,04414,72475.0%75.0%
28.57%75.191010,88733.3%25.0%
57.14%75.36167,27560.0%50.0%
14.29%76.467711,3330.0%50.0%
33.33%66.61,06311,61020.0%100.0%
50.00%66.090813,57850.0%50.0%
33.33%64.290910,53933.3%0.0%
50.00%65.91,00111,45050.0%50.0%
16.67%66.366411,6560.0%50.0%
83.33%63.794012,48466.7%100.0%
50.00%65.776410,47450.0%50.0%
40.00%52.985514,3690.0%40.0%
60.00%57.394411,6170.0%100.0%
60.00%52.58059,80066.7%50.0%
40.00%56.086014,4070.0%100.0%
80.00%52.962412,089100.0%66.7%
40.00%53.392311,80150.0%33.3%
20.00%55.978210,08333.3%0.0%
60.00%56.41,41715,830100.0%50.0%
40.00%53.377114,1990.0%50.0%
20.00%55.471911,3500.0%33.3%
80.00%56.986810,38280.0%0.0%

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Vayne vs Annie - Frequently Asked Questions

How does Vayne do against Annie in League of Legends?

Annie wins the Vayne vs Annie matchup with a 83.3% win rate compared to Vayne's 16.7%, a 66.7 percentage point difference. This data is based on 6 recent ranked games in patch 26.5.

How does Vayne do against Annie in the early game?

In the early game, Annie has the advantage against Vayne with a 100.0% win rate versus 0.0%. Annie players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Annie in the late game?

In the late game, Vayne takes over the Vayne vs Annie matchup with a 50.0% win rate compared to 50.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Annie matchup?

Annie wins the matchup against Vayne with a 83.3% win rate in League of Legends patch 26.5. The 66.7 percentage point advantage means Annie is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Vayne build against Annie?

The best Vayne build against Annie includes Stormrazor, Experimental Hexplate, Infinity Edge with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Annie?

The best Vayne runes against Annie use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Annie matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Annie?

No, Vayne struggles against Annie with only a 16.7% win rate. Annie has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Annie's lead.

How do I play Vayne against Annie?

When playing Vayne against Annie, play cautiously and avoid Annie's power spikes. Focus on safe farming — you outscale Annie in the late game. Use the matchup-specific build and runes above to optimize your chances.