Vayne - League of Legends Champion
Win Rate
49.9%
Pick Rate
5.2%

Vaynevs Zilean

BMarksmanAssassin
Patch26.10
Matches1,492,117
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 19, 2026
MethodologyData Methodology

Vayne vs Zilean is a decisive matchup in LoL patch 26.10. Zilean wins with a 66.7% win rate (+33.3%) over Vayne based on 6 games. Zilean holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Zilean matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zilean - 33.3% win rateZilean(33.3%)
Vayne - 33.3% win rate in this matchup
Vayne
33.3% WR
VS
Zilean vs Vayne matchup - 66.7% win rate
Zilean
66.7% WR

Who Wins the Vayne vs Zilean Matchup?

Zilean wins the Vayne vs Zilean matchup
Winner
Zilean
Matches: 6
33.3%
Win Rate
66.7%
5.6
CS / min
4.0
648
DMG / min
343
9,334
Gold / game
8,527
135
Heal / min
275
359
DMG Mitigated / min
424
0.3
CC / min
1.1
40.0%
Early Game WR
60.0%
0.0%
Late Game WR
100.0%

Vayne vs Zilean Matchup Summary

The Vayne vs Zilean matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Zilean wins with a 66.7% win rate compared to Vayne's 33.3%, giving Zilean a 33.3 percentage point advantage. Zilean dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Zilean leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zilean has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zilean overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Zilean Laning Phase Breakdown

Vayne wins the laning phase against Zilean in League of Legends

Vayne is favored during the laning phase against Zilean, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.6Vayne
4.0Zilean
Vayne significantly out-farms Zilean by 1.5 CS per minute, accumulating an estimated 23 CS lead by mid game. This substantial farming gap gives Vayne a major gold advantage and earlier item completions. Zilean players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
648Vayne
343Zilean
Vayne heavily out-damages Zilean by 305 DMG/min, dominating both short trades and all-in fights. Zilean should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
9,334Vayne
8,527Zilean
Vayne generates a commanding 807 more gold per game than Zilean. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zilean should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Vayne
1.1Zilean
Zilean brings significantly more crowd control than Vayne, with 0.8 more seconds of CC per minute. This large utility gap makes Zilean far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
495Vayne
699Zilean
Zilean vastly out-sustains Vayne, healing and mitigating 204 more damage per minute. This massive durability gap means Zilean can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Zilean
60.0%
+20.0% advantage
Vayne early game win rateVayne40.0%
Zilean early game win rateZilean60.0%
Late Game
Zilean
100.0%
+100.0% advantage
Vayne late game win rateVayne0.0%
Zilean late game win rateZilean100.0%

Zilean dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Vayne. This lopsided early game means Zilean can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zilean is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Zilean, whose kit and scaling make them a dominant force in team fights and objective control.

Zilean holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Zilean

Precision rune tree - Vayne primary runes vs ZileanPrecision
Press the Attack - best Vayne rune vs ZileanTriumph - best Vayne rune vs ZileanLegend: Alacrity - best Vayne rune vs ZileanCoup de Grace - best Vayne rune vs Zilean
Resolve rune tree - Vayne secondary runes vs ZileanResolve
Conditioning - best Vayne rune vs ZileanOvergrowth - best Vayne rune vs Zilean
100.0% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Zilean in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.57%9026.186213,15945.4%40.7%
47.55%6526.079512,93447.6%47.5%
47.46%6496.082712,96346.2%48.5%
53.24%5246.286413,23951.5%54.6%
53.92%5236.086613,33951.2%55.8%
51.67%4785.778212,80449.3%53.4%
55.50%4186.286813,21855.1%55.8%
56.96%3166.391413,84752.2%60.6%
54.13%2186.187012,96848.5%59.1%
51.40%2146.180912,47246.1%56.3%
46.63%2085.877912,88644.3%48.6%
48.95%1906.082613,00955.6%44.0%
56.45%1866.596012,44954.8%57.8%
46.95%1646.084112,38544.3%49.4%
49.08%1636.277112,95847.4%50.6%
40.25%1595.562811,02929.2%47.9%
52.29%1535.977712,73438.8%62.8%
42.38%1516.081013,18041.3%43.2%
53.79%1456.191912,09249.1%56.5%
48.25%1436.585713,08046.3%50.0%
50.72%1386.190011,75848.2%52.4%
35.94%1285.558710,69526.9%42.1%
49.59%1236.282413,17450.0%49.3%
48.25%1145.982613,54842.9%51.4%
50.88%1146.286413,17552.3%50.0%
47.71%1096.290712,97546.9%48.3%
47.71%1095.991211,61147.1%48.3%
56.00%1005.883212,20554.5%57.1%
53.41%886.61,11513,10744.1%59.3%
45.12%826.31,31412,12938.9%50.0%
51.25%805.687811,60146.0%55.8%
51.28%786.076610,53151.5%51.1%
50.00%726.51,00611,95758.3%41.7%
45.83%726.195112,08238.5%50.0%
60.87%696.688611,87054.3%67.7%
47.06%686.086711,81150.0%45.2%
45.59%686.21,02712,84959.1%39.1%
55.22%675.81,06512,23957.1%53.9%
50.77%656.095911,77643.8%57.6%
41.67%606.372011,47742.4%40.7%
58.33%606.286212,62650.0%63.9%
47.27%556.183513,19656.3%43.6%
55.56%546.885311,69257.1%53.9%
53.70%546.098911,70457.1%50.0%
57.41%546.482912,95962.5%53.3%
50.00%546.090213,30147.8%51.6%
54.72%536.384113,16162.5%48.3%
51.92%526.094710,87360.9%44.8%
49.02%515.885312,49150.0%48.5%
50.98%516.187111,72348.0%53.9%
54.00%505.585512,57038.9%62.5%
60.00%456.597411,85655.0%64.0%
39.53%435.568010,79029.4%46.1%
57.14%426.574612,64766.7%51.9%
53.66%416.390512,91646.7%57.7%
65.00%406.486413,14857.1%73.7%
43.59%396.193012,14937.5%47.8%
58.97%395.894413,88161.5%57.7%
57.89%386.489411,76147.6%70.6%
48.65%376.31,03911,94364.3%39.1%
43.24%376.069612,38233.3%52.6%
52.78%364.786111,58250.0%55.6%
36.11%365.577613,01736.4%36.0%
38.24%345.976612,10142.9%35.0%
61.76%346.074312,05160.0%63.2%
48.48%335.196413,57537.5%52.0%
60.61%335.880312,59275.0%47.1%
53.13%326.492714,75945.5%57.1%
53.13%326.087911,41057.1%50.0%
43.75%326.393212,09040.0%50.0%
58.06%316.81,00611,80658.8%57.1%
53.33%306.288910,26442.1%72.7%
55.17%294.582212,08350.0%58.8%
64.29%286.485613,46060.0%66.7%
55.56%275.281912,06546.1%64.3%
30.77%266.075011,72228.6%33.3%
52.00%256.685012,39542.9%55.6%
48.00%254.367011,23250.0%46.1%
50.00%245.778811,08730.0%64.3%
33.33%246.194913,34240.0%31.6%
54.17%245.781710,53846.1%63.6%
47.83%235.981814,10016.7%58.8%
40.91%226.51,04511,98930.0%50.0%
54.55%226.188514,12044.4%61.5%
57.14%216.390311,38972.7%40.0%
30.00%206.266510,19141.7%12.5%
52.63%195.266310,26840.0%66.7%
55.56%186.267811,85750.0%60.0%
52.94%172.696913,48550.0%55.6%
52.94%176.61,02412,33757.1%50.0%
37.50%165.867511,25720.0%45.5%
43.75%166.384711,93344.4%42.9%
33.33%152.970012,04133.3%33.3%
53.33%156.674111,92642.9%62.5%
46.67%155.879311,09328.6%62.5%
50.00%145.888812,4310.0%70.0%
71.43%143.693113,32057.1%85.7%
50.00%146.71,10714,47475.0%40.0%
28.57%147.083813,13328.6%28.6%
53.85%136.094011,49466.7%42.9%
38.46%136.298613,77533.3%40.0%
33.33%122.75568,36222.2%66.7%
33.33%124.363010,80550.0%25.0%
58.33%125.51,09913,90050.0%60.0%
36.36%113.870814,04820.0%50.0%
40.00%103.91,02413,92340.0%40.0%
90.00%105.586013,857100.0%85.7%
40.00%104.759812,2950.0%40.0%
40.00%105.71,08810,65940.0%40.0%
22.22%96.297911,05550.0%0.0%
37.50%85.673614,3170.0%37.5%
37.50%84.866012,16333.3%40.0%
50.00%82.072912,93350.0%50.0%
25.00%85.799811,77350.0%0.0%
50.00%84.687213,40166.7%40.0%
71.43%73.862013,24450.0%100.0%
28.57%75.089314,24733.3%25.0%
57.14%74.273911,98266.7%50.0%
28.57%73.368810,2530.0%40.0%
66.67%65.570412,76266.7%66.7%
33.33%65.66489,33440.0%0.0%
33.33%65.17398,93350.0%0.0%
33.33%66.66789,21533.3%33.3%
83.33%65.71,02314,239100.0%80.0%
33.33%63.679511,50133.3%33.3%
80.00%51.386714,38366.7%100.0%
60.00%52.684212,65650.0%66.7%
80.00%54.797416,6750.0%80.0%
40.00%56.51,08412,39933.3%50.0%
20.00%50.968514,5790.0%25.0%

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Vayne vs Zilean - Frequently Asked Questions

How does Vayne do against Zilean in League of Legends?

Zilean wins the Vayne vs Zilean matchup with a 66.7% win rate compared to Vayne's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.10.

How does Vayne do against Zilean in the early game?

In the early game, Zilean has the advantage against Vayne with a 60.0% win rate versus 40.0%. Zilean players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Zilean in the late game?

In the late game, Zilean takes over the Vayne vs Zilean matchup with a 100.0% win rate compared to 0.0%. Zilean scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Zilean matchup?

Zilean wins the matchup against Vayne with a 66.7% win rate in League of Legends patch 26.10. The 33.3 percentage point advantage means Zilean is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Vayne build against Zilean?

The best Vayne build against Zilean includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Zilean?

The best Vayne runes against Zilean use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Zilean matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Zilean?

No, Vayne struggles against Zilean with only a 33.3% win rate. Zilean has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Zilean's lead.

How do I play Vayne against Zilean?

When playing Vayne against Zilean, play cautiously and avoid Zilean's power spikes. Look for jungle assistance and team-dependent plays since Zilean has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.