Seraphinevs Karthus
Seraphine vs Karthus is a decisive matchup in LoL patch 26.5. Seraphine wins with a 57.1% win rate (+14.3%) over Karthus based on 7 games. Seraphine wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Karthus matchup.
Seraphine Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Karthus(57.1%)Who Wins the Seraphine vs Karthus Matchup?
Seraphine vs Karthus Matchup Summary
The Seraphine vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Seraphine wins with a 57.1% win rate compared to Karthus's 42.9%, giving Seraphine a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Karthus leads by 552 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Seraphine vs Karthus Laning Phase Breakdown
Karthus is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Seraphine75.0%Karthus25.0%Seraphine33.3%Karthus66.7%Seraphine dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Karthus is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Seraphine. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Seraphine Runes Against Karthus
Sorcery
Inspiration
Running Sorcery primary with Inspiration secondary allows Seraphine to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.
Seraphine matchup data for League of Legends patch 26.5. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 48.97% | 243 | 1.6 | 438 | 9,318 | 48.2% | 49.6% | |
| 50.41% | 242 | 1.3 | 435 | 8,930 | 44.8% | 54.7% | |
| 49.41% | 170 | 1.4 | 470 | 9,087 | 53.7% | 45.5% | |
| 48.41% | 157 | 1.4 | 465 | 9,269 | 62.5% | 36.5% | |
| 56.00% | 150 | 1.5 | 451 | 9,370 | 57.8% | 54.6% | |
| 46.21% | 132 | 1.4 | 457 | 8,348 | 50.0% | 41.4% | |
| 49.60% | 125 | 1.4 | 481 | 9,394 | 50.9% | 48.6% | |
| 45.45% | 110 | 1.7 | 499 | 9,395 | 59.5% | 36.8% | |
| 51.43% | 105 | 1.6 | 483 | 9,652 | 58.5% | 46.9% | |
| 42.31% | 104 | 1.3 | 393 | 8,406 | 32.7% | 51.9% | |
| 51.46% | 103 | 1.3 | 421 | 8,660 | 56.9% | 46.1% | |
| 50.00% | 100 | 1.4 | 482 | 9,589 | 42.2% | 56.4% | |
| 53.00% | 100 | 1.4 | 487 | 9,258 | 45.8% | 59.6% | |
| 54.55% | 99 | 1.6 | 459 | 9,765 | 47.1% | 58.5% | |
| 48.35% | 91 | 1.6 | 451 | 9,556 | 50.0% | 47.5% | |
| 63.33% | 90 | 1.3 | 357 | 8,994 | 72.1% | 55.3% | |
| 50.57% | 87 | 1.3 | 489 | 9,144 | 56.8% | 46.0% | |
| 56.63% | 83 | 1.3 | 439 | 9,348 | 52.5% | 60.5% | |
| 58.02% | 81 | 1.2 | 452 | 8,978 | 54.5% | 60.4% | |
| 52.56% | 78 | 1.3 | 466 | 9,334 | 50.0% | 54.5% | |
| 48.68% | 76 | 1.8 | 587 | 9,763 | 41.2% | 54.8% | |
| 50.00% | 72 | 1.8 | 467 | 9,202 | 48.6% | 51.4% | |
| 54.29% | 70 | 1.5 | 494 | 9,429 | 40.6% | 65.8% | |
| 51.47% | 68 | 1.5 | 586 | 9,128 | 50.0% | 52.8% | |
| 50.94% | 53 | 1.7 | 475 | 9,275 | 52.0% | 50.0% | |
| 53.06% | 49 | 1.7 | 503 | 9,922 | 50.0% | 54.8% | |
| 50.00% | 48 | 1.4 | 443 | 9,035 | 47.4% | 51.7% | |
| 40.43% | 47 | 1.2 | 533 | 9,813 | 36.8% | 42.9% | |
| 50.00% | 42 | 1.3 | 476 | 8,721 | 42.1% | 56.5% | |
| 47.62% | 42 | 2.9 | 502 | 10,146 | 62.5% | 38.5% | |
| 54.76% | 42 | 1.6 | 467 | 9,534 | 35.7% | 64.3% | |
| 43.59% | 39 | 1.2 | 420 | 9,350 | 20.0% | 58.3% | |
| 57.89% | 38 | 6.1 | 774 | 12,590 | 50.0% | 62.5% | |
| 44.12% | 34 | 1.3 | 504 | 8,683 | 44.4% | 43.8% | |
| 54.55% | 33 | 1.3 | 466 | 9,666 | 56.3% | 52.9% | |
| 48.48% | 33 | 1.4 | 461 | 8,861 | 46.1% | 50.0% | |
| 51.72% | 29 | 6.3 | 878 | 14,654 | 50.0% | 52.2% | |
| 66.67% | 27 | 1.6 | 452 | 9,171 | 73.3% | 58.3% | |
| 42.31% | 26 | 5.6 | 740 | 13,114 | 75.0% | 36.4% | |
| 44.00% | 25 | 2.2 | 516 | 8,959 | 41.7% | 46.1% | |
| 50.00% | 24 | 2.5 | 511 | 9,637 | 66.7% | 40.0% | |
| 59.09% | 22 | 1.4 | 447 | 10,110 | 45.5% | 72.7% | |
| 47.62% | 21 | 6.4 | 786 | 12,860 | 62.5% | 38.5% | |
| 38.10% | 21 | 1.9 | 444 | 8,085 | 42.9% | 28.6% | |
| 61.90% | 21 | 6.4 | 703 | 12,637 | 66.7% | 58.3% | |
| 73.68% | 19 | 1.2 | 415 | 8,346 | 70.0% | 77.8% | |
| 55.56% | 18 | 1.5 | 544 | 9,052 | 37.5% | 70.0% | |
| 55.56% | 18 | 6.1 | 744 | 14,226 | 25.0% | 64.3% | |
| 41.18% | 17 | 1.8 | 424 | 9,268 | 42.9% | 40.0% | |
| 52.94% | 17 | 4.2 | 578 | 10,399 | 87.5% | 22.2% | |
| 62.50% | 16 | 6.1 | 645 | 10,497 | 50.0% | 75.0% | |
| 68.75% | 16 | 4.3 | 605 | 10,245 | 40.0% | 81.8% | |
| 62.50% | 16 | 7.0 | 709 | 11,736 | 80.0% | 33.3% | |
| 37.50% | 16 | 3.5 | 551 | 11,181 | 42.9% | 33.3% | |
| 53.33% | 15 | 2.2 | 431 | 8,855 | 66.7% | 33.3% | |
| 73.33% | 15 | 1.3 | 488 | 10,339 | 80.0% | 70.0% | |
| 60.00% | 15 | 1.9 | 389 | 9,273 | 57.1% | 62.5% | |
| 50.00% | 12 | 6.3 | 697 | 12,434 | 40.0% | 57.1% | |
| 50.00% | 12 | 4.6 | 603 | 10,850 | 75.0% | 37.5% | |
| 45.45% | 11 | 2.2 | 747 | 11,601 | 50.0% | 42.9% | |
| 45.45% | 11 | 4.9 | 673 | 10,868 | 40.0% | 50.0% | |
| 70.00% | 10 | 3.6 | 568 | 10,799 | 100.0% | 62.5% | |
| 40.00% | 10 | 3.1 | 571 | 10,598 | 25.0% | 50.0% | |
| 55.56% | 9 | 5.9 | 666 | 10,864 | 33.3% | 66.7% | |
| 33.33% | 9 | 6.2 | 597 | 11,210 | 40.0% | 25.0% | |
| 55.56% | 9 | 6.3 | 628 | 10,733 | 66.7% | 50.0% | |
| 66.67% | 9 | 5.7 | 851 | 12,287 | 60.0% | 75.0% | |
| 66.67% | 9 | 1.9 | 750 | 10,393 | 50.0% | 80.0% | |
| 44.44% | 9 | 5.7 | 491 | 10,099 | 25.0% | 60.0% | |
| 50.00% | 8 | 4.3 | 515 | 8,326 | 60.0% | 33.3% | |
| 50.00% | 8 | 1.2 | 413 | 11,217 | 0.0% | 50.0% | |
| 50.00% | 8 | 6.2 | 465 | 9,309 | 60.0% | 33.3% | |
| 37.50% | 8 | 1.9 | 493 | 6,421 | 25.0% | 50.0% | |
| 42.86% | 7 | 5.8 | 732 | 14,140 | 50.0% | 40.0% | |
| 57.14% | 7 | 1.8 | 408 | 9,277 | 33.3% | 75.0% | |
| 57.14% | 7 | 5.4 | 621 | 10,398 | 100.0% | 50.0% | |
| 71.43% | 7 | 2.8 | 445 | 9,627 | 50.0% | 100.0% | |
| 42.86% | 7 | 6.1 | 493 | 10,461 | 50.0% | 33.3% | |
| 57.14% | 7 | 4.3 | 684 | 11,601 | 75.0% | 33.3% | |
| 16.67% | 6 | 5.0 | 523 | 9,338 | 0.0% | 33.3% | |
| 66.67% | 6 | 1.7 | 609 | 8,097 | 75.0% | 50.0% | |
| 66.67% | 6 | 4.7 | 603 | 11,169 | 100.0% | 33.3% | |
| 50.00% | 6 | 6.3 | 555 | 6,620 | 60.0% | 0.0% | |
| 100.00% | 6 | 3.3 | 449 | 10,147 | 100.0% | 100.0% | |
| 50.00% | 6 | 4.8 | 673 | 10,580 | 100.0% | 25.0% | |
| 66.67% | 6 | 3.6 | 578 | 10,780 | 100.0% | 50.0% | |
| 60.00% | 5 | 4.3 | 544 | 11,315 | 100.0% | 50.0% | |
| 60.00% | 5 | 2.7 | 572 | 11,314 | 0.0% | 100.0% | |
| 40.00% | 5 | 2.5 | 719 | 11,709 | 33.3% | 50.0% | |
| 40.00% | 5 | 5.1 | 623 | 9,386 | 33.3% | 50.0% | |
| 20.00% | 5 | 5.2 | 552 | 11,349 | 50.0% | 0.0% | |
| 60.00% | 5 | 6.1 | 726 | 12,011 | 66.7% | 50.0% | |
| 60.00% | 5 | 6.8 | 594 | 11,832 | 33.3% | 100.0% | |
| 100.00% | 5 | 7.1 | 753 | 13,337 | 100.0% | 100.0% | |
| 60.00% | 5 | 4.6 | 752 | 14,784 | 100.0% | 50.0% | |
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Seraphine vs Karthus - Frequently Asked Questions
How does Seraphine do against Karthus in League of Legends?
Seraphine wins the Seraphine vs Karthus matchup with a 57.1% win rate compared to Karthus's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.5.
How does Seraphine do against Karthus in the early game?
In the early game, Seraphine has the advantage against Karthus with a 75.0% win rate versus 25.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Seraphine do against Karthus in the late game?
In the late game, Karthus takes over the Seraphine vs Karthus matchup with a 66.7% win rate compared to 33.3%. Karthus scales better into team fights and objective contests after 25 minutes.
Who wins the Seraphine vs Karthus matchup?
Seraphine wins the matchup against Karthus with a 57.1% win rate in League of Legends patch 26.5. The 14.3 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 7 games analyzed.
What is the best Seraphine build against Karthus?
The best Seraphine build against Karthus includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Seraphine runes against Karthus?
The best Seraphine runes against Karthus use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Karthus matchup. See the full rune breakdown in the matchup comparison above.
Does Seraphine counter Karthus?
Yes, Seraphine has a favorable matchup against Karthus with a 57.1% win rate. Seraphine strongly counters Karthus in lane based on current patch 26.5 data.
How do I play Seraphine against Karthus?
When playing Seraphine against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.