Vayne - League of Legends Champion
Win Rate
50.0%
Pick Rate
5.2%

Vaynevs Kha'Zix

BMarksmanAssassin
Patch26.10
Matches1,009,027
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Vayne vs Kha'Zix is a decisive matchup in LoL patch 26.10. Vayne wins with a 57.1% win rate (+14.3%) over Kha'Zix based on 7 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Kha'Zix matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kha'Zix - 57.1% win rateKha'Zix(57.1%)
Vayne - 57.1% win rate in this matchup
Vayne
57.1% WR
VS
Kha'Zix vs Vayne matchup - 42.9% win rate
Kha'Zix
42.9% WR

Who Wins the Vayne vs Kha'Zix Matchup?

Vayne wins the Vayne vs Kha'Zix matchup
Winner
Vayne
Matches: 7
57.1%
Win Rate
42.9%
1.0
CS / min
0.8
659
DMG / min
607
13,566
Gold / game
12,860
404
Heal / min
428
475
DMG Mitigated / min
509
0.5
CC / min
0.2
50.0%
Early Game WR
50.0%
66.7%
Late Game WR
33.3%

Vayne vs Kha'Zix Matchup Summary

The Vayne vs Kha'Zix matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Vayne wins with a 57.1% win rate compared to Kha'Zix's 42.9%, giving Vayne a 14.3 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Kha'Zix players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Vayne leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Kha'Zix and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Kha'Zix away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Kha'Zix Laning Phase Breakdown

Vayne wins the laning phase against Kha'Zix in League of Legends

Vayne is favored during the laning phase against Kha'Zix, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.0Vayne
0.8Kha'Zix
Vayne and Kha'Zix farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
659Vayne
607Kha'Zix
Vayne deals 52 more champion damage per minute than Kha'Zix. While noticeable in extended trades, this gap can be offset by Kha'Zix choosing favorable fight windows, such as engaging when Vayne's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
13,566Vayne
12,860Kha'Zix
Vayne earns 706 more gold per game than Kha'Zix, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.5Vayne
0.2Kha'Zix
Both Vayne and Kha'Zix provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
878Vayne
937Kha'Zix
Kha'Zix heals and mitigates 59 more damage per minute than Vayne, providing moderate extra durability. This sustain edge allows Kha'Zix to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Vayne.

Best Vayne Build Against Kha'Zix

Berserker's Greaves is the optimal boots choice against Kha'Zix, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Kha'Zix are Terminus, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Kha'Zix matchup.

Early Game vs Late Game

Early Game
Vayne
50.0%
+0.0% advantage
Vayne early game win rateVayne50.0%
Kha'Zix early game win rateKha'Zix50.0%
Late Game
Vayne
66.7%
+33.3% advantage
Vayne late game win rateVayne66.7%
Kha'Zix late game win rateKha'Zix33.3%

The early game (first 15 minutes) is a toss-up between Vayne and Kha'Zix, with Vayne holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Kha'Zix. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Kha'Zix players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Kha'Zix

Precision rune tree - Vayne primary runes vs Kha'ZixPrecision
Lethal Tempo - best Vayne rune vs Kha'ZixTriumph - best Vayne rune vs Kha'ZixLegend: Bloodline - best Vayne rune vs Kha'ZixCut Down - best Vayne rune vs Kha'Zix
Inspiration rune tree - Vayne secondary runes vs Kha'ZixInspiration
Cash Back - best Vayne rune vs Kha'ZixJack Of All Trades - best Vayne rune vs Kha'Zix
100.0% WR

Running Precision primary with Inspiration secondary allows Vayne to press their advantage against Kha'Zix, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.79%8886.187313,42543.8%42.2%
45.78%6516.183212,92942.2%49.0%
48.13%6426.079912,92043.9%51.2%
53.42%5266.184213,10753.0%53.8%
51.10%5016.080012,97847.5%53.5%
50.31%4855.876912,32347.6%52.7%
49.35%3836.384512,93348.2%50.2%
53.27%3066.391613,43450.7%55.4%
53.62%2356.086412,64049.6%57.4%
54.59%2076.183412,66748.9%59.3%
47.29%2035.980413,16448.8%46.2%
48.15%1896.185513,55151.4%46.2%
49.11%1696.084412,90648.1%50.0%
45.51%1676.081812,76943.1%47.4%
46.99%1666.277612,77449.4%44.9%
48.77%1626.595411,99745.2%51.7%
39.75%1615.862010,95728.8%48.9%
50.63%1606.589913,74644.8%54.8%
59.73%1496.489911,99949.2%67.4%
59.12%1376.091811,82360.3%58.2%
46.67%1356.080513,26436.4%53.8%
31.34%1345.556510,41421.4%38.5%
45.08%1226.281212,58444.4%45.8%
42.02%1196.084812,89935.3%47.1%
40.71%1136.384313,35245.5%37.7%
49.54%1096.387912,55455.8%43.9%
57.14%1056.183812,22757.1%57.1%
47.52%1015.992311,20553.1%42.3%
58.62%876.172810,51751.2%65.2%
54.02%876.51,11012,89542.1%63.3%
46.34%825.688511,27345.0%47.6%
48.72%786.11,30512,21745.5%51.1%
51.35%746.079811,63060.0%45.5%
54.29%705.71,11912,77750.0%56.5%
43.48%696.193512,09237.5%46.7%
50.00%686.496012,25767.7%35.1%
58.82%686.985811,92157.6%60.0%
52.31%656.691911,61948.4%55.9%
51.72%586.31,00412,69160.9%45.7%
47.17%536.482911,66048.4%45.5%
48.08%526.277812,96940.9%53.3%
65.38%526.190112,18565.2%65.5%
50.00%526.299612,61152.9%48.6%
49.02%516.089111,77545.5%51.7%
52.94%515.878913,08645.0%58.1%
52.00%506.11,03113,73050.0%53.6%
58.33%485.975411,85658.8%58.1%
52.08%486.21,07512,35247.4%55.2%
58.70%466.492212,82560.9%56.5%
45.65%466.187812,27036.0%57.1%
59.09%445.988513,40042.1%72.0%
65.91%446.588712,62471.4%60.9%
41.86%435.976712,17650.0%37.9%
50.00%425.681411,71250.0%50.0%
65.85%414.788011,77569.6%61.1%
60.00%406.297511,57856.3%62.5%
48.72%395.582212,49557.1%44.0%
55.26%386.385312,78562.5%50.0%
50.00%386.586012,42650.0%50.0%
50.00%366.085410,98050.0%50.0%
62.86%356.395612,63158.3%65.2%
45.71%355.678510,66629.4%61.1%
68.57%355.971011,76068.8%68.4%
45.45%334.982512,05018.2%59.1%
51.61%316.384413,16546.1%55.6%
54.84%316.479312,36658.3%52.6%
56.67%306.492610,44042.1%81.8%
60.00%306.082813,52050.0%63.6%
37.93%296.297813,97050.0%33.3%
53.57%285.185912,05146.1%60.0%
50.00%286.387512,48542.9%57.1%
35.71%286.173810,27726.7%46.1%
51.85%275.985614,50250.0%52.6%
37.04%276.591710,35928.6%46.1%
48.15%275.676812,78136.4%56.3%
50.00%264.770511,60150.0%50.0%
34.62%265.986911,15830.8%38.5%
46.15%266.188412,59760.0%42.9%
44.00%255.46408,87031.3%66.7%
68.00%256.588012,13066.7%68.8%
45.83%245.873110,71650.0%41.7%
52.17%236.184913,28733.3%64.3%
39.13%236.090710,46630.8%50.0%
30.43%235.872811,24718.2%41.7%
57.14%216.287513,99137.5%69.2%
57.14%213.496513,01458.3%55.6%
60.00%206.31,04112,75760.0%60.0%
35.29%175.973211,73928.6%40.0%
56.25%166.081713,55725.0%66.7%
62.50%164.81,11613,76050.0%75.0%
53.33%156.099014,4700.0%72.7%
60.00%156.098911,79762.5%57.1%
33.33%156.483412,17566.7%11.1%
42.86%146.166210,38250.0%33.3%
57.14%146.895614,50483.3%37.5%
42.86%144.975114,0450.0%46.1%
50.00%146.51,11113,81366.7%37.5%
50.00%145.81,02411,71466.7%45.5%
38.46%134.063411,63550.0%33.3%
53.85%136.085511,23837.5%80.0%
50.00%126.470210,98140.0%57.1%
33.33%126.386213,28920.0%42.9%
66.67%122.484313,17450.0%75.0%
41.67%123.980212,00340.0%42.9%
54.55%112.083310,53842.9%75.0%
45.45%114.874010,87828.6%75.0%
54.55%115.097314,27966.7%50.0%
36.36%116.693310,38360.0%16.7%
54.55%115.51,10012,54325.0%71.4%
70.00%105.690313,78850.0%83.3%
50.00%102.874712,54320.0%80.0%
77.78%97.01,05114,103100.0%60.0%
55.56%94.31,00013,94133.3%66.7%
44.44%92.988115,885100.0%37.5%
55.56%93.585112,68933.3%66.7%
62.50%81.777112,33966.7%60.0%
50.00%85.477711,605100.0%20.0%
37.50%82.073912,73325.0%50.0%
57.14%72.25918,26750.0%66.7%
28.57%75.769712,250100.0%16.7%
57.14%71.065913,56650.0%66.7%
57.14%72.41,29615,60766.7%50.0%
50.00%64.399614,68650.0%50.0%
16.67%66.87488,36520.0%0.0%
50.00%63.21,12817,178100.0%40.0%
33.33%66.28279,58025.0%50.0%
60.00%56.163311,23366.7%50.0%
80.00%55.11,03613,35450.0%100.0%
20.00%57.179310,59033.3%0.0%
80.00%54.783512,087100.0%66.7%
60.00%53.885011,66050.0%66.7%
80.00%52.41,03614,100100.0%75.0%

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Vayne vs Kha'Zix - Frequently Asked Questions

How does Vayne do against Kha'Zix in League of Legends?

Vayne wins the Vayne vs Kha'Zix matchup with a 57.1% win rate compared to Kha'Zix's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.10.

How does Vayne do against Kha'Zix in the early game?

In the early game, Vayne has the advantage against Kha'Zix with a 50.0% win rate versus 50.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Kha'Zix in the late game?

In the late game, Vayne takes over the Vayne vs Kha'Zix matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Kha'Zix matchup?

Vayne wins the matchup against Kha'Zix with a 57.1% win rate in League of Legends patch 26.10. The 14.3 percentage point advantage means Vayne is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Vayne build against Kha'Zix?

The best Vayne build against Kha'Zix includes Terminus, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Kha'Zix?

The best Vayne runes against Kha'Zix use the Precision primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Kha'Zix matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Kha'Zix?

Yes, Vayne has a favorable matchup against Kha'Zix with a 57.1% win rate. Vayne strongly counters Kha'Zix in lane based on current patch 26.10 data.

How do I play Vayne against Kha'Zix?

When playing Vayne against Kha'Zix, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.