Vayne - League of Legends Champion
Win Rate
50.0%
Pick Rate
5.2%

Vaynevs Qiyana

BMarksmanAssassin
Patch26.10
Matches1,009,027
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Vayne vs Qiyana is a decisive matchup in LoL patch 26.10. Vayne wins with a 80.0% win rate (+60.0%) over Qiyana based on 5 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Qiyana matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Qiyana - 80.0% win rateQiyana(80.0%)
Vayne - 80.0% win rate in this matchup
Vayne
80.0% WR
VS
Qiyana vs Vayne matchup - 20.0% win rate
Qiyana
20.0% WR

Who Wins the Vayne vs Qiyana Matchup?

Vayne wins the Vayne vs Qiyana matchup
Winner
Vayne
Matches: 5
80.0%
Win Rate
20.0%
4.7
CS / min
4.2
835
DMG / min
788
12,087
Gold / game
10,608
320
Heal / min
184
490
DMG Mitigated / min
467
0.4
CC / min
0.7
100.0%
Early Game WR
0.0%
66.7%
Late Game WR
33.3%

Vayne vs Qiyana Matchup Summary

The Vayne vs Qiyana matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Vayne wins with a 80.0% win rate compared to Qiyana's 20.0%, giving Vayne a 60.0 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Qiyana players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Qiyana leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Qiyana and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Qiyana away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Qiyana Laning Phase Breakdown

Vayne wins the laning phase against Qiyana in League of Legends

Vayne is favored during the laning phase against Qiyana, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
4.7Vayne
4.2Qiyana
Vayne edges out Qiyana by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
835Vayne
788Qiyana
Vayne deals 47 more champion damage per minute than Qiyana. While noticeable in extended trades, this gap can be offset by Qiyana choosing favorable fight windows, such as engaging when Vayne's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
12,087Vayne
10,608Qiyana
Vayne generates a commanding 1,479 more gold per game than Qiyana. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Qiyana should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.7Qiyana
Both Vayne and Qiyana provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
810Vayne
651Qiyana
Vayne vastly out-sustains Qiyana, healing and mitigating 159 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Qiyana is forced to recall. Building grievous wounds early is essential for Qiyana, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Qiyana

Berserker's Greaves is the optimal boots choice against Qiyana, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Qiyana are Jak'Sho, The Protean, Blade of The Ruined King and Randuin's Omen. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Qiyana. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Qiyana matchup.

Early Game vs Late Game

Early Game
Vayne
100.0%
+100.0% advantage
Vayne early game win rateVayne100.0%
Qiyana early game win rateQiyana0.0%
Late Game
Vayne
66.7%
+33.3% advantage
Vayne late game win rateVayne66.7%
Qiyana late game win rateQiyana33.3%

Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Qiyana. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Qiyana. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Qiyana players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Qiyana

Precision rune tree - Vayne primary runes vs QiyanaPrecision
Lethal Tempo - best Vayne rune vs QiyanaTriumph - best Vayne rune vs QiyanaLegend: Alacrity - best Vayne rune vs QiyanaCoup de Grace - best Vayne rune vs Qiyana
Resolve rune tree - Vayne secondary runes vs QiyanaResolve
Conditioning - best Vayne rune vs QiyanaOvergrowth - best Vayne rune vs Qiyana
100.0% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Qiyana, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.79%8886.187313,42543.8%42.2%
45.78%6516.183212,92942.2%49.0%
48.13%6426.079912,92043.9%51.2%
53.42%5266.184213,10753.0%53.8%
51.10%5016.080012,97847.5%53.5%
50.31%4855.876912,32347.6%52.7%
49.35%3836.384512,93348.2%50.2%
53.27%3066.391613,43450.7%55.4%
53.62%2356.086412,64049.6%57.4%
54.59%2076.183412,66748.9%59.3%
47.29%2035.980413,16448.8%46.2%
48.15%1896.185513,55151.4%46.2%
49.11%1696.084412,90648.1%50.0%
45.51%1676.081812,76943.1%47.4%
46.99%1666.277612,77449.4%44.9%
48.77%1626.595411,99745.2%51.7%
39.75%1615.862010,95728.8%48.9%
50.63%1606.589913,74644.8%54.8%
59.73%1496.489911,99949.2%67.4%
59.12%1376.091811,82360.3%58.2%
46.67%1356.080513,26436.4%53.8%
31.34%1345.556510,41421.4%38.5%
45.08%1226.281212,58444.4%45.8%
42.02%1196.084812,89935.3%47.1%
40.71%1136.384313,35245.5%37.7%
49.54%1096.387912,55455.8%43.9%
57.14%1056.183812,22757.1%57.1%
47.52%1015.992311,20553.1%42.3%
58.62%876.172810,51751.2%65.2%
54.02%876.51,11012,89542.1%63.3%
46.34%825.688511,27345.0%47.6%
48.72%786.11,30512,21745.5%51.1%
51.35%746.079811,63060.0%45.5%
54.29%705.71,11912,77750.0%56.5%
43.48%696.193512,09237.5%46.7%
50.00%686.496012,25767.7%35.1%
58.82%686.985811,92157.6%60.0%
52.31%656.691911,61948.4%55.9%
51.72%586.31,00412,69160.9%45.7%
47.17%536.482911,66048.4%45.5%
48.08%526.277812,96940.9%53.3%
65.38%526.190112,18565.2%65.5%
50.00%526.299612,61152.9%48.6%
49.02%516.089111,77545.5%51.7%
52.94%515.878913,08645.0%58.1%
52.00%506.11,03113,73050.0%53.6%
58.33%485.975411,85658.8%58.1%
52.08%486.21,07512,35247.4%55.2%
58.70%466.492212,82560.9%56.5%
45.65%466.187812,27036.0%57.1%
59.09%445.988513,40042.1%72.0%
65.91%446.588712,62471.4%60.9%
41.86%435.976712,17650.0%37.9%
50.00%425.681411,71250.0%50.0%
65.85%414.788011,77569.6%61.1%
60.00%406.297511,57856.3%62.5%
48.72%395.582212,49557.1%44.0%
55.26%386.385312,78562.5%50.0%
50.00%386.586012,42650.0%50.0%
50.00%366.085410,98050.0%50.0%
62.86%356.395612,63158.3%65.2%
45.71%355.678510,66629.4%61.1%
68.57%355.971011,76068.8%68.4%
45.45%334.982512,05018.2%59.1%
51.61%316.384413,16546.1%55.6%
54.84%316.479312,36658.3%52.6%
56.67%306.492610,44042.1%81.8%
60.00%306.082813,52050.0%63.6%
37.93%296.297813,97050.0%33.3%
53.57%285.185912,05146.1%60.0%
50.00%286.387512,48542.9%57.1%
35.71%286.173810,27726.7%46.1%
51.85%275.985614,50250.0%52.6%
37.04%276.591710,35928.6%46.1%
48.15%275.676812,78136.4%56.3%
50.00%264.770511,60150.0%50.0%
34.62%265.986911,15830.8%38.5%
46.15%266.188412,59760.0%42.9%
44.00%255.46408,87031.3%66.7%
68.00%256.588012,13066.7%68.8%
45.83%245.873110,71650.0%41.7%
52.17%236.184913,28733.3%64.3%
39.13%236.090710,46630.8%50.0%
30.43%235.872811,24718.2%41.7%
57.14%216.287513,99137.5%69.2%
57.14%213.496513,01458.3%55.6%
60.00%206.31,04112,75760.0%60.0%
35.29%175.973211,73928.6%40.0%
56.25%166.081713,55725.0%66.7%
62.50%164.81,11613,76050.0%75.0%
53.33%156.099014,4700.0%72.7%
60.00%156.098911,79762.5%57.1%
33.33%156.483412,17566.7%11.1%
42.86%146.166210,38250.0%33.3%
57.14%146.895614,50483.3%37.5%
42.86%144.975114,0450.0%46.1%
50.00%146.51,11113,81366.7%37.5%
50.00%145.81,02411,71466.7%45.5%
38.46%134.063411,63550.0%33.3%
53.85%136.085511,23837.5%80.0%
50.00%126.470210,98140.0%57.1%
33.33%126.386213,28920.0%42.9%
66.67%122.484313,17450.0%75.0%
41.67%123.980212,00340.0%42.9%
54.55%112.083310,53842.9%75.0%
45.45%114.874010,87828.6%75.0%
54.55%115.097314,27966.7%50.0%
36.36%116.693310,38360.0%16.7%
54.55%115.51,10012,54325.0%71.4%
70.00%105.690313,78850.0%83.3%
50.00%102.874712,54320.0%80.0%
77.78%97.01,05114,103100.0%60.0%
55.56%94.31,00013,94133.3%66.7%
44.44%92.988115,885100.0%37.5%
55.56%93.585112,68933.3%66.7%
62.50%81.777112,33966.7%60.0%
50.00%85.477711,605100.0%20.0%
37.50%82.073912,73325.0%50.0%
57.14%72.25918,26750.0%66.7%
28.57%75.769712,250100.0%16.7%
57.14%71.065913,56650.0%66.7%
57.14%72.41,29615,60766.7%50.0%
50.00%64.399614,68650.0%50.0%
16.67%66.87488,36520.0%0.0%
50.00%63.21,12817,178100.0%40.0%
33.33%66.28279,58025.0%50.0%
60.00%56.163311,23366.7%50.0%
80.00%55.11,03613,35450.0%100.0%
20.00%57.179310,59033.3%0.0%
80.00%54.783512,087100.0%66.7%
60.00%53.885011,66050.0%66.7%
80.00%52.41,03614,100100.0%75.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Vayne vs Qiyana - Frequently Asked Questions

How does Vayne do against Qiyana in League of Legends?

Vayne wins the Vayne vs Qiyana matchup with a 80.0% win rate compared to Qiyana's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Vayne do against Qiyana in the early game?

In the early game, Vayne has the advantage against Qiyana with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Qiyana in the late game?

In the late game, Vayne takes over the Vayne vs Qiyana matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Qiyana matchup?

Vayne wins the matchup against Qiyana with a 80.0% win rate in League of Legends patch 26.10. The 60.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Vayne build against Qiyana?

The best Vayne build against Qiyana includes Jak'Sho, The Protean, Blade of The Ruined King, Randuin's Omen with Berserker's Greaves. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Qiyana?

The best Vayne runes against Qiyana use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Qiyana matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Qiyana?

Yes, Vayne has a favorable matchup against Qiyana with a 80.0% win rate. Vayne strongly counters Qiyana in lane based on current patch 26.10 data.

How do I play Vayne against Qiyana?

When playing Vayne against Qiyana, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.