Slay the Spire 2 Defect Relic Tier List

S-tier is led by Ghost Seed, which dominates the meta with a 100.0% win rate on a 0.6% pick rate. They are followed by Blessed Antler (100.0%), Glitter (83.3%), Iron Club (80.0%), Sword of Jade (75.0%), Signet Ring (75.0%), Sai (71.4%), and Astrolabe (71.4%). The remaining 26 relics in this tier average a 57.5% win rate. These relics define the current meta and are the safest, highest-impact picks. In terms of popularity, Tiny Mailbox is the crowd favourite here at a 5.1% pick rate, while Ghost Seed is slept on at just 0.6% — a strong S-tier pick flying under the radar.

B-tier is led by Lizard Tail, which holds steady with a 50.0% win rate on a 3.3% pick rate. They are followed by Seal of Gold (50.0%), Pocketwatch (50.0%), Precise Scissors (50.0%), Pandora's Box (50.0%), Anchor??? (50.0%), Fur Coat (50.0%), and Distinguished Cape (50.0%). The remaining 26 relics in this tier average a 43.6% win rate. These relics are balanced and fully viable with solid execution. In terms of popularity, Blood Vial is the crowd favourite here at a 12.0% pick rate, while Seal of Gold is slept on at just 0.6% — a strong B-tier pick flying under the radar.

C-tier is led by Orichalcum???, which struggles with a 40.0% win rate on a 1.0% pick rate. They are followed by Lasting Candy (39.1%), Lantern (38.9%), Meat on the Bone (38.5%), Red Mask (38.3%), Candelabra (37.9%), Ripple Basin (37.5%), and Happy Flower??? (37.5%). The remaining 38 relics in this tier average a 33.6% win rate. These relics are situational and need favourable matchups or team comps to shine. Despite the low ranking, Potion Belt stays popular at a 12.8% pick rate, meaning players overvalue it relative to its C-tier results, while Ember Tea (0.6%) is more rightly avoided.

D-tier is led by Stone Calendar, which struggles with a 30.8% win rate on a 2.6% pick rate. They are followed by Sparkling Rouge (30.4%), Vajra (30.0%), Juzu Bracelet (30.0%), Pael's Legion (30.0%), Orrery (30.0%), Neow's Torment (30.0%), and Mercury Hourglass (29.0%). The remaining 49 relics in this tier average a 24.4% win rate. These relics underperform against the current meta and take extra effort to win with. Despite the low ranking, Regal Pillow stays popular at a 12.0% pick rate, meaning players overvalue it relative to its D-tier results, while Massive Scroll (0.8%) is more rightly avoided.

F-tier is led by Pael's Claw, which struggles with a 20.0% win rate on a 2.4% pick rate. They are followed by Bellows (20.0%), Nutritious Oyster (20.0%), Old Coin (20.0%), Silver Crucible (20.0%), Bing Bong (20.0%), Booming Conch (20.0%), and Tuning Fork (19.1%). The remaining 50 relics in this tier average a 8.4% win rate. These relics are the weakest options this patch and are best avoided in ranked. Despite the low ranking, Cracked Core stays popular at a 94.3% pick rate, meaning players overvalue it relative to its F-tier results, while Sling of Courage (0.6%) is more rightly avoided.