Slay the Spire 2 Defect Relic Tier List

S-tier is led by Ghost Seed, which dominates the meta with a 100.0% win rate on a 0.5% pick rate. They are followed by Blessed Antler (100.0%), Iron Club (85.7%), Sword of Jade (85.7%), Glitter (71.4%), Biiig Hug (66.7%), Sai (66.7%), and Emotion Chip (66.7%). The remaining 26 relics in this tier average a 57.1% win rate. These relics define the current meta and are the safest, highest-impact picks. In terms of popularity, Fragrant Mushroom is the crowd favourite here at a 3.6% pick rate, while Ghost Seed is slept on at just 0.5% — a strong S-tier pick flying under the radar.

B-tier is led by Anchor???, which holds steady with a 50.0% win rate on a 3.1% pick rate. They are followed by Brilliant Scarf (50.0%), Fur Coat (50.0%), Distinguished Cape (50.0%), Dream Catcher (50.0%), Hand Drill (50.0%), Ringing Triangle (50.0%), and Lord's Parasol (45.5%). The remaining 27 relics in this tier average a 41.9% win rate. These relics are balanced and fully viable with solid execution. In terms of popularity, Blood Vial is the crowd favourite here at a 11.1% pick rate, while Hand Drill is slept on at just 0.5% — a strong B-tier pick flying under the radar.

C-tier is led by Pendulum, which struggles with a 37.7% win rate on a 10.4% pick rate. They are followed by Kifuda (37.5%), Lee's Waffle (37.5%), Golden Compass (37.5%), Infused Core (37.5%), Touch of Orobas (37.5%), Bronze Scales (37.3%), and Letter Opener (37.0%). The remaining 39 relics in this tier average a 33.2% win rate. These relics are situational and need favourable matchups or team comps to shine. Despite the low ranking, Potion Belt stays popular at a 12.2% pick rate, meaning players overvalue it relative to its C-tier results, while Music Box (0.5%) is more rightly avoided.

D-tier is led by Mummified Hand, which struggles with a 30.0% win rate on a 1.7% pick rate. They are followed by Daughter of the Wind (30.0%), Whetstone (29.6%), Planisphere (29.4%), Mercury Hourglass (29.4%), Runic Capacitor (29.4%), Shuriken (29.4%), and Akabeko (29.3%). The remaining 50 relics in this tier average a 25.1% win rate. These relics underperform against the current meta and take extra effort to win with. Despite the low ranking, Bag of Preparation stays popular at a 11.3% pick rate, meaning players overvalue it relative to its D-tier results, while Massive Scroll (0.7%) is more rightly avoided.

F-tier is led by Neow's Bones, which struggles with a 20.0% win rate on a 5.1% pick rate. They are followed by Sling of Courage (20.0%), The Abacus (20.0%), Wongo's Mystery Ticket (20.0%), Booming Conch (20.0%), Archaic Tooth (18.8%), Gremlin Horn (18.2%), and Pael's Claw (18.2%). The remaining 50 relics in this tier average a 9.1% win rate. These relics are the weakest options this patch and are best avoided in ranked. Despite the low ranking, Cracked Core stays popular at a 94.2% pick rate, meaning players overvalue it relative to its F-tier results, while Storybook (0.5%) is more rightly avoided.