Slay the Spire 2 Regent Card Tier List

S-tier is led by Apotheosis, which dominates the meta with a 100.0% win rate on a 0.6% pick rate. They are followed by Dark Shackles (100.0%), Catastrophe (100.0%), Mad Science (73.3%), Mayhem (71.4%), Stratagem (60.0%), Decay (60.0%), and Brightest Flame (60.0%). The remaining 14 cards in this tier average a 45.9% win rate. These cards define the current meta and are the safest, highest-impact picks. In terms of popularity, The Smith is the crowd favourite here at a 7.7% pick rate, while Apotheosis is slept on at just 0.6% — a strong S-tier pick flying under the radar.

B-tier is led by Big Bang, which struggles with a 40.0% win rate on a 12.4% pick rate. They are followed by Foregone Conclusion (40.0%), Debt (40.0%), Prowess (40.0%), Master of Strategy (40.0%), Heirloom Hammer (38.5%), Cosmic Indifference (38.2%), and Tyranny (38.1%). The remaining 14 cards in this tier average a 34.5% win rate. These cards are balanced and fully viable with solid execution. In terms of popularity, Glow is the crowd favourite here at a 27.7% pick rate, while Regret is slept on at just 0.6% — a strong B-tier pick flying under the radar.

C-tier is led by Seeker Strike, which struggles with a 33.3% win rate on a 0.8% pick rate. They are followed by Panache (33.3%), Exterminate (33.3%), Alchemize (33.3%), Jackpot (33.3%), Folly (33.3%), Burst (33.3%), and Stardust (32.7%). The remaining 22 cards in this tier average a 28.5% win rate. These cards are situational and need favourable matchups or team comps to shine. Despite the low ranking, Reflect stays popular at a 18.6% pick rate, meaning players overvalue it relative to its C-tier results, while Alchemize (0.6%) is more rightly avoided.

D-tier is led by Clumsy, which struggles with a 26.5% win rate on a 7.5% pick rate. They are followed by Know Thy Place (26.4%), Child of the Stars (26.4%), Quasar (26.3%), Black Hole (25.6%), Gather Light (25.5%), Particle Wall (25.4%), and Comet (25.0%). The remaining 29 cards in this tier average a 22.0% win rate. These cards underperform against the current meta and take extra effort to win with. Despite the low ranking, Gather Light stays popular at a 35.4% pick rate, meaning players overvalue it relative to its D-tier results, while Feeding Frenzy (1.0%) is more rightly avoided.

F-tier is led by Wrought in War, which struggles with a 19.2% win rate on a 17.4% pick rate. They are followed by Collision Course (19.1%), Patter (18.4%), Conqueror (18.0%), Shining Strike (16.9%), Solar Strike (16.9%), I Am Invincible (16.7%), and Knockout Blow (16.7%). The remaining 30 cards in this tier average a 8.6% win rate. These cards are the weakest options this patch and are best avoided in ranked. Despite the low ranking, Venerate stays popular at a 98.5% pick rate, meaning players overvalue it relative to its F-tier results, while Automation (0.6%) is more rightly avoided.