Slay the Spire 2 Regent Card Tier List

S-tier is led by Dark Shackles, which dominates the meta with a 100.0% win rate on a 0.6% pick rate. They are followed by Catastrophe (100.0%), Believe in You (100.0%), Apotheosis (75.0%), Stratagem (66.7%), Mayhem (62.5%), Mad Science (60.9%), and Master of Strategy (57.1%). The remaining 15 cards in this tier average a 45.0% win rate. These cards define the current meta and are the safest, highest-impact picks. In terms of popularity, Void Form is the crowd favourite here at a 7.6% pick rate, while Catastrophe is slept on at just 0.4% — a strong S-tier pick flying under the radar.

B-tier is led by Prowess, which struggles with a 40.0% win rate on a 0.7% pick rate. They are followed by Feeding Frenzy (40.0%), Heirloom Hammer (39.3%), Big Bang (39.1%), Dramatic Entrance (38.5%), The Sealed Throne (38.5%), Cosmic Indifference (38.4%), and Fasten (37.5%). The remaining 16 cards in this tier average a 34.6% win rate. These cards are balanced and fully viable with solid execution. In terms of popularity, Bulwark is the crowd favourite here at a 14.2% pick rate, while Beacon of Hope is slept on at just 0.4% — a strong B-tier pick flying under the radar.

C-tier is led by Bad Luck, which struggles with a 33.3% win rate on a 0.4% pick rate. They are followed by Dying Star (32.3%), GUARDS!!! (32.1%), Neutron Aegis (32.1%), Alignment (32.0%), Monologue (31.3%), Furnace (31.2%), and Parry (31.2%). The remaining 24 cards in this tier average a 29.4% win rate. These cards are situational and need favourable matchups or team comps to shine. Despite the low ranking, Glow stays popular at a 27.5% pick rate, meaning players overvalue it relative to its C-tier results, while Bad Luck (0.4%) is more rightly avoided.

D-tier is led by Royalties, which struggles with a 28.0% win rate on a 4.1% pick rate. They are followed by Convergence (27.8%), CHARGE!! (27.8%), Crash Landing (27.8%), Child of the Stars (27.4%), Comet (26.9%), Manifest Authority (26.9%), and Hegemony (26.8%). The remaining 31 cards in this tier average a 23.7% win rate. These cards underperform against the current meta and take extra effort to win with. Despite the low ranking, Gather Light stays popular at a 37.2% pick rate, meaning players overvalue it relative to its D-tier results, while Hand of Greed (0.7%) is more rightly avoided.

F-tier is led by Bolas, which struggles with a 20.0% win rate on a 0.9% pick rate. They are followed by Jack of All Trades (20.0%), Shining Strike (19.4%), Kingly Punch (19.4%), Guiding Star (19.1%), Venerate (17.9%), Terraforming (17.6%), and Falling Star (17.6%). The remaining 32 cards in this tier average a 8.8% win rate. These cards are the weakest options this patch and are best avoided in ranked. Despite the low ranking, Venerate stays popular at a 97.5% pick rate, meaning players overvalue it relative to its F-tier results, while Byrdonis Egg (0.4%) is more rightly avoided.