Slay the Spire 2 Regent Card Tier List

This Slay the Spire 2 Regent card tier list ranks the 118 Regent cards with enough recorded data by their win rate when played as the Regent, sorting them into S, B, C, D and F tiers. Unlike the all-classes ranking, every placement here is based on how each card performs specifically in Regent runs — so a card that is only average overall can be a top Regent pick. Tiers use the same percentile method as the rest of the site: the top 15% of cards by Regent win rate land in S, the next 15% in B, and so on down to F. Right now the strongest Regent cards — the S tier — are led by Mad Science, Mayhem, Stratagem, with Mad Science posting the highest Regent win rate at 100.0%. Use it to prioritise your card rewards on a Regent run, build around the cards that actually win for the class, and skip the low-tier picks. Win rates update as more Regent runs are recorded.